North Carolina is currently home to 2618 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of TJ033721 (givastomig) in Subjects with Advanced or Metastatic Solid Tumors
NCT04900818
Recruiting
This is an open label, multi-center, multiple dose Phase 1 study to evaluate the safety, tolerability, MTD PK, and PD of TJ033721 (givastomig) in subjects with advanced or metastatic solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/02/2025
Locations: Carolina BioOncology Institute, Huntersville, North Carolina
Conditions: Solid Tumor, Advanced Cancer, Metastatic Cancer, Gastric Cancer, Gastroesophageal Junction Carcinoma, Esophageal Adenocarcinoma
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Study of Cretostimogene Given in Patients With Non-Muscle Invasive Bladder Cancer ,Unresponsive to Bacillus-Calmette-Guerin
NCT04452591
Recruiting
This is a Phase 3, open-label, single arm trial designed to evaluate Cretostimogene patients with NMIBC who have failed prior BCG therapy. Up to approximately 115 CIS bladder cancer patients with or without HG Ta or HG T1 papillary disease will be enrolled under the original protocol through Amendment 4, which will comprise Cohort C. Cohort C is closed to enrollment. Under Amendment 5-1, Cohort P was added to enroll up to 70 patients with HG Ta/T1 papillary bladder cancer. Under Amendment 6, t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/02/2025
Locations: Duke University, Durham, North Carolina
Conditions: Non Muscle Invasive Bladder Cancer, High-grade Ta/ T1 Papillary Disease Bladder Cancer
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NICU Antibiotics and Outcomes Trial
NCT03997266
Recruiting
The goal of the NANO trial is to study the longstanding clinical practice of empirically administering intravenous antibiotics to extremely low birthweight (ELBW) infants in the first days of life. In this 802-subject multicenter placebo-controlled randomized clinical trial, the hypothesis to be tested is that the incidence of adverse outcomes is higher in babies receiving empiric antibiotics (EA) in the first week of life compared to babies receiving placebo. The study targets a population of E... Read More
Gender:
ALL
Ages:
4 hours and below
Trial Updated:
01/02/2025
Locations: Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina
Conditions: Microbial Colonization, Extreme Prematurity, Early-Onset Neonatal Sepsis, Late-Onset Neonatal Sepsis, Necrotizing Enterocolitis of Newborn, Death; Neonatal
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Screening for AL Amyloidosis in Smoldering Multiple Myeloma
NCT06365060
Recruiting
In this multicenter study, we will recruit 400 patients 40 years of age or older at 15 centers with a diagnosis of smoldering multiple myeloma (SMM), a group of patients for whom standard of care is observation not treatment. The main goal of this study is to screen for the diagnosis of light-chain amyloidosis (AL) before the onset of symptomatic disease and to develop a training set for a likelihood algorithm.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
12/31/2024
Locations: Atrium Health Levine Cancer Institute, Charlotte, North Carolina
Conditions: Smoldering Multiple Myeloma
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Organ Retractor Device Study
NCT06754514
Recruiting
This study aims to assess the safety and efficacy of an organ retraction device. The study is low risk as it is only being used in patients already undergoing primary robotic bariatric surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/30/2024
Locations: WakeMed Health & Hospitals, Raleigh, North Carolina
Conditions: Liver Retraction During Bariatric Surgery
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Deucravacitinib Adherence Study
NCT05570955
Recruiting
Psoriasis patients are very poorly adherent to topical treatment. If adherence issues are ignored, poor adherence may limit the real-world efficacy of deucravacitinib, too. Forty psoriasis patients recruited from Wake Forest Baptist Health Dermatology Clinic will be enrolled. Twenty will be randomized to a reporting intervention designed to promote better adherence and the remaining 20 patients will serve as controls who will not receive a reporting intervention. Through qualitative interviews o... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/30/2024
Locations: Wake Forest University Health Sciences Department of Dermatology, Winston-Salem, North Carolina
Conditions: Psoriasis
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Xeomin® and Gait Related Mobility After Stroke
NCT04908423
Recruiting
The aim of the present pilot study is to evaluate the association between change in gait related mobility in ambulatory male and female adult hemiparetic patients before and 4-6-weeks after Xeomin® injection into the upper limb, using two standardized tests of physical function in outpatient rehabilitation that are widely used; the 10-meter walk test and the timed 'up and go' test (TUG).
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
12/30/2024
Locations: Carolinas Rehabilitation, Charlotte, North Carolina
Conditions: Stroke
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Pelvic and Acetabular Fracture: A Prospective Observational Study
NCT04615104
Recruiting
The purpose of this study is to understand the trajectory of function and self-reported outcomes of patients following pelvic and acetabular, treated both operatively and nonoperatively.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/30/2024
Locations: Atrium Health- Carolinas Medical Center, Charlotte, North Carolina
Conditions: Pelvic Fracture, Acetabular Fracture, Pubic Rami Fracture
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Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
NCT02915198
Recruiting
This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in Veterans who have pre-diabetes and heart or blood vessel problems.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/27/2024
Locations: Durham VA Medical Center, Durham, NC, Durham, North Carolina
Conditions: Prediabetic State, Atherosclerosis, Metformin
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Preference of Women With Recurrent Urinary Tract Infection for Vaginal Estradiol Tablet vs Cream
NCT05723601
Recruiting
Vaginally applied estrogen has been shown to decrease the incidence of Recurrent Urinary Tract Infection (rUTI) in post-menopausal women. However, prior studies have shown the compliance rate for topical estrogen cream is low. The vaginal estradiol tablet has been shown to be preferred by patients being treated for genitourinary syndrome of menopause and has improved compliance. There are no studies looking at the preference of post-menopausal women with rUTI for vaginal estradiol tablet as an a... Read More
Gender:
FEMALE
Ages:
Between 20 years and 80 years
Trial Updated:
12/26/2024
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Recurrent Urinary Tract Infection
Register for Updates
NextGen - Clinical Implication of Next Generation Sequencing
NCT05206500
Recruiting
Recently more advanced techniques, including Polymerase Chain Reaction (PCR) and Next Generation Sequencing (NGS) are available to detect bacteria in urine based on bacterial genomes. Comparing to traditional culture, these techniques have more sensitivity and could potentially be of a great help in patients with Colony Count of less than 10,000 and more than zero.
Gender:
FEMALE
Ages:
Between 18 years and 80 years
Trial Updated:
12/26/2024
Locations: Wake Forest Health Sciences, Winston-Salem, North Carolina
Conditions: Urinary Tract Infections
Register for Updates
Effects of Systematic Cervical Exam Training on Labor and Delivery Care
NCT04421768
Recruiting
All physicians, nurses, and nurse midwives working on Labor and Delivery will be required to complete cervical exam simulation training. Data before and after institution of the training will be compared to determine if the training leads to less cervical exams during labor and increases consistency between examiners
Gender:
ALL
Ages:
All
Trial Updated:
12/26/2024
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Delivery Problem, Cervix; Pregnancy, Pregnancy Related
Register for Updates