North Carolina is currently home to 2646 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Cryocompression to Reduce Chemotherapy-induced Peripheral Neuropathy in Gynecologic Cancer - COHORT 2
NCT06139458
Recruiting
The investigators aim to determine the effect of cryotherapy wraps plus compression therapy (henceforth referred to as cryocompression) versus cryotherapy wraps alone on the incidence and degree of chemotherapy-induced peripheral neuropathy in patients with gynecologic cancer using a noninferiority design. The investigators also aim to determine the effect of cryocompression versus cryotherapy on patient tolerability and patient and staff satisfaction.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Gynecologic Cancer, Chemotherapy-induced Peripheral Neuropathy
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MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions
NCT05908331
Recruiting
A Prospective, Multicenter, Randomized, Two-Arm, Single-blind Superiority Trial to Evaluate the Safety and Efficacy of the MagicTouch™ Sirolimus- Coated Balloon in the Treatment of Coronary Drug-Eluting Stent In-Stent Restenosis. Subjects with prior DES implantation presenting with ISR lesions undergoing PCI will be randomized into two groups: treatment with the MagicTouch™ sirolimus-coated balloon or POBA on a 2:1 basis. Approximately 492 subjects will be enrolled in the randomized study in a... Read More
Gender:
ALL
Ages:
Between 18 years and 110 years
Trial Updated:
02/24/2025
Locations: NC Heart and Vascular Research, LLC, Raleigh, North Carolina
Conditions: In-Stent Restenosis, Cardiovascular Diseases, Coronary Artery Disease
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Brain Structure and Clinical Endpoints in Myotonic Dystrophy Type 2
NCT05854433
Recruiting
Nearly two-third of patients with myotonic dystrophy type 2 (DM2) report that impaired cognition is among the most disabling symptoms and deeply affects their quality of life. Yet, relatively little is known about how DM2 affects brain structure and cognitive function as brain imaging studies in DM2 are extremely limited. This is a prospective, cross-sectional study of brain structure and function on cognitive and motor performance in patients with DM2 compared to healthy controls. All participa... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
02/24/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Myotonic Dystrophy Type 2
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SPEARHEAD-3 Pediatric Study
NCT05642455
Recruiting
This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A\*02 eligible and MAGE-A4 positive subjects aged 2-21 years of age with advanced cancers
Gender:
ALL
Ages:
Between 2 years and 21 years
Trial Updated:
02/24/2025
Locations: Duke University School of Medicine, Durham, North Carolina
Conditions: Synovial Sarcoma, Malignant Peripheral Nerve Sheath Tumor (MPNST), Neuroblastoma, Osteosarcoma
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A Comparison of the Outcomes in Fortiva and Strattice Mesh
NCT05572021
Recruiting
A comparison of ventral hernia repair with Strattice and Fortiva mesh.Primary The study team aims to determine the hernia recurrence rates for RTI Surgical biologic mesh (Fortiva) compared to Strattice. Also the study team aims to determine the mesh related complications for RTI Surgical biologic mesh (Fortiva) compared to Strattice
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
02/24/2025
Locations: Carolinas Medical Center, Charlotte, North Carolina
Conditions: Ventral Hernia
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A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial)
NCT05488340
Recruiting
This is a Phase 2 superiority study of LBP-EC01, a recombinant bacteriophage cocktail, with an initial open-label 3-arm pharmacokinetic (PK) lead-in portion of 30 patients to evaluate the optimal dosing regimen to be used in the subsequent 288 patient blinded portion of the study which will be randomized 1:1 comparing LBP-EC01 + antibiotic versus placebo + antibiotic in patients with a history of prior urinary tract infection (UTI) cased by E. coli. All patients will be required to have an activ... Read More
Gender:
FEMALE
Ages:
Between 18 years and 75 years
Trial Updated:
02/24/2025
Locations: Research Site 118, Winston-Salem, North Carolina
Conditions: Urinary Tract Infections
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Examining the Effects of Estradiol on Neural and Molecular Response to Reward
NCT05282277
Recruiting
This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR).
Gender:
FEMALE
Ages:
Between 45 years and 55 years
Trial Updated:
02/24/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Depression, Psychosis, Anhedonia
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Safety and Efficacy of Aloe Vera in the Management of the Symptoms of Interstitial Cystitis
NCT04734106
Recruiting
The purpose of this study is to assess the safety and efficacy of super-concentrated, freeze-dried aloe vera capsules for treatment of interstitial cystitis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Wake Forest Baptist Hospital, Winston-Salem, North Carolina
Conditions: Interstitial Cystitis, Chronic Interstitial Cystitis, Bladder Pain Syndrome
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The Arteriovenous Vascular (AV) ACCESS Trial
NCT04646226
Recruiting
This study is to prospectively compare the effectiveness and safety of the two types of arteriovenous access placement (fistula or graft) in older adults with end stage kidney disease and multiple chronic conditions
Gender:
ALL
Ages:
60 years and above
Trial Updated:
02/24/2025
Locations: Atrium Wake Forest Baptist Medical Center, Winston-Salem, North Carolina
Conditions: End-Stage Kidney Disease, Hemodialysis Complication
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CivaDerm(TM) Surface Therapy Pilot Study
NCT04480645
Recruiting
This is a pilot study to determine the usefulness of new brachytherapy device that utilizes active components (palladium-103) of standard devices in a novel configuration, which may benefit basal cell and squamous cell carcinoma patients by providing conformal radiation therapy to the surface of the skin.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: CivaDerm Oncology PLLC, Morrisville, North Carolina
Conditions: Basal Cell Carcinoma, Squamous Cell Carcinoma of the Skin
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Pediatric Post-Approval Registry
NCT04457154
Recruiting
This registry is a prospective, multi-center, single-arm study of pediatric subjects (ages 18-21 years) who are undergoing implant of the Inspire Upper Airway Stimulation (UAS) System for the treatment of moderate or severe obstructive sleep apnea (OSA). Implanted subjects will be followed for 5 years post-implant.
Gender:
ALL
Ages:
Between 18 years and 21 years
Trial Updated:
02/24/2025
Locations: Duke University, Durham, North Carolina
Conditions: Obstructive Sleep Apnea
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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
NCT03907046
Recruiting
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF). Secondary Aim: To determine if apixaban, compared with aspirin, results in better functional outcomes as measured by the modified Rankin Scale.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: University of North Carolina Medical Center, Chapel Hill, North Carolina
Conditions: Intracerebral Hemorrhage, Atrial Fibrillation
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