North Carolina is currently home to 2630 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Neuroblastoma Maintenance Therapy Trial
NCT02679144
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, single agent, multicenter, study for patients with neuroblastoma in remission. In this study subjects will receive 730 Days of oral difluoromethylornithine (DFMO) at a dose of 750 mg/m2 ± 250 mg/m2 BID (strata 1, 2, 3, and 4) OR 2500 mg/m2 BID (stratum 1B) on each day of study. This study will focus on the use of DFMO in high risk neuroblastoma patients that are in remission as a strategy to prevent recurrence.
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
09/18/2024
Locations: Levine Children's Hospital, Charlotte, North Carolina
Conditions: Neuroblastoma
Register for Updates
First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors
NCT06554795
Recruiting
A Phase 1/2a First-in-Human Study of DB-1419 in Advanced/Metastatic Solid Tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/17/2024
Locations: Site USA03, Carolina, North Carolina
Conditions: Solid Tumor, Adult
Register for Updates
Reducing Fluid Overload in Heart Failure Patients Using a Non-invasive, Renal Independent System
NCT06360380
Recruiting
The REFORM-HF study aims to test a new technology, AquaPass, designed to assist patients experiencing symptoms of fluid overload due to Heart Failure. Patients will wear a lightweight suit that helps remove excess fluids through their sweat. The investigators want to see if the AquaPass system can remove an additional 500mL of fluids during treatment, alongside patients' regular medications like diuretics. Participants will select if to be treated at their home or in the outpatient clinic.
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
09/17/2024
Locations: Cone Health Advanced Heart Failure Clinic at Moses Cone, Greensboro, North Carolina
Conditions: Chronic Heart Failure, CKD Stage 3
Register for Updates
Phase 2 Study of EDG-5506 in Children and Adolescents with Duchenne Muscular Dystrophy Previously Treated with Gene Therapy (FOX)
NCT06100887
Recruiting
The FOX study is a 2-part, multicenter, Phase 2 study of safety, pharmacokinetics, and biomarkers in children and adolescents with Duchenne muscular dystrophy previously treated with gene therapy including a randomized, double-blind, placebo-controlled Part A, followed by an open-label part B.
Gender:
MALE
Ages:
Between 6 years and 17 years
Trial Updated:
09/17/2024
Locations: Rare Disease Research, Hillsborough, North Carolina
Conditions: Duchenne Muscular Dystrophy
Register for Updates
Telehealth to Improve Functional Status and Quality of Life in Veterans With PAD
NCT05048979
Recruiting
The present study aims to increase Veteran access to supervised exercise therapy and expand its role in improving functional status, quality of life, and cardiovascular risk profile of Veterans with PAD.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/17/2024
Locations: Durham VA Medical Center, Durham, NC, Durham, North Carolina
Conditions: Peripheral Artery Disease
Register for Updates
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
NCT04251052
Recruiting
This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk... Read More
Gender:
FEMALE
Ages:
Between 35 years and 50 years
Trial Updated:
09/17/2024
Locations: Duke Cancer Institute Cary, Cary, North Carolina
Conditions: Ovarian Carcinoma
Register for Updates
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of VYN201 Gel in Subjects with Non-segmental Vitiligo.
NCT06493578
Recruiting
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of VYN201 Gel in subjects with non-segmental vitiligo.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
09/16/2024
Locations: Hickory Dermatology Research Center, Hickory, North Carolina
Conditions: Non-segmental Vitiligo
Register for Updates
Next Generation Rocklatan
NCT06441643
Recruiting
The purpose of this two-stage clinical trial is to assess the safety and hypotensive efficacy of AR-17043 and PG043 ophthalmic solutions in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/16/2024
Locations: James D. Branch Ophthalmology, Winston-Salem, North Carolina
Conditions: Open Angle Glaucoma, Ocular Hypertension
Register for Updates
VIA Disc NP Registry 3.0
NCT06345690
Recruiting
Registry is to observe and trend patterns of care and outcomes for patients treated with VIA Disc NP.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/16/2024
Locations: Premier Pain Solutions, Asheville, North Carolina
Conditions: Discogenic Pain, Back Pain, Back Pain, Low
Register for Updates
Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)
NCT06071377
Recruiting
The main purpose of this study is to create a longitudinal cohort of those with Sickle Cell Trait (SCT) to better understand the hematologic phenotype for those that carry HbS, assess for differences in those with varying quantities of HbS and assess for potential clinical complications of SCT.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/16/2024
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Sickle Cell Trait
Register for Updates
Novel Intervention for Chronic Complex TBI in OEF/OIF/OND Veterans
NCT05671692
Recruiting
The goal of this clinical trial is to compare pregnenolone and placebo (a placebo is a look-alike substance that contains no active drug) in Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND)-Era Veterans with a history of chronic Traumatic Brain Injury (TBI). The main questions it aims to answer are: * Does pregnenolone improve psychological health, overall physical function, cognition, symptoms of PTSD, and pain more than placebo over the 8-week study period,... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
09/16/2024
Locations: Duke University School of Medicine, Durham, North Carolina
Conditions: Traumatic Brain Injury, TBI
Register for Updates
Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA)
NCT05416333
Recruiting
The purpose of this pilot study is to determine if azelaic acid shows potential to be an effective treatment for Central Centrifugal Cicatricial Alopecia (CCCA). In this study, the aim is to compare azelaic acid vs placebo since azelaic acid may increase anti-inflammatory effects that affect the hair growth cycle.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/16/2024
Locations: Wake Forest University Health Scieces, Winston-Salem, North Carolina
Conditions: Central Centrifugal Cicatricial Alopecia
Register for Updates