North Carolina is currently home to 2664 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Training for Urinary Leakage Improvement After Pregnancy
NCT06411158
Recruiting
This is a multi-center, randomized single-blind nonsurgical trial conducted in approximately 216 primiparous postpartum women at high risk for prolonged/sustained pelvic floor disorders with symptomatic, bothersome urinary incontinence (UI) amenable to nonsurgical treatment. TULIP is a 3-Arm trial with two active interventions (Arms 1 and 2) and a Patient Education control arm (Arm 3). Arm 1 consists of pelvic floor muscle training (PFMT). Arm 2 uses a home biofeedback device (leva®). The prim... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Duke University, Duke Division of Urogynecology and Reconstructive Pelvic Surgery, Durham, North Carolina
Conditions: Urinary Incontinence, Delivery Complication
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GI Alpha-Gal Study
NCT06268717
Recruiting
This is a double-blind, crossover food challenge study using pork with and without α-gal in patients with a clinical diagnosis of gastrointestinal (GI)- α-gal allergy, and to investigate the pathophysiology underlying their symptoms.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/13/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Alpha-Gal Syndrome, Irritable Bowel Syndrome, Diarrhea, Abdominal Pain, Vomiting
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Pharmacokinetics, Pharmacodynamics and Safety of Epeleuton in Patients with Sickle Cell Disease
NCT05861453
Recruiting
To assess the pharmacokinetics, pharmacodynamics and safety of Epeleuton capsules in adult SCD patients who are aged ≥18 years.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: UNC Health, Chapel Hill, North Carolina
Conditions: Sickle Cell Disease
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Atypical Hemolytic-Uremic Syndrome (aHUS) Registry
NCT01522183
Recruiting
Post-marketing safety data on patients treated and untreated with eculizumab or ravulizumab.
Gender:
ALL
Ages:
All
Trial Updated:
11/13/2024
Locations: Clinical Trial Site, Winston-Salem, North Carolina
Conditions: Atypical Hemolytic-Uremic Syndrome
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Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier
NCT06426628
Recruiting
The goal of this observational study is to learn how a physician uses the results of the Percepta® Nasal Swab test to manage people with a newly identified pulmonary nodule. The main questions it aims to answer are: * Does the use of the Percepta Nasal swab test reduce the number of invasive procedures in people with a low-risk result and whose nodule is benign? * Does the use of the Percepta Nasal swab test decrease the time to treatment in people with a high-risk result and whose nodule is c... Read More
Gender:
ALL
Ages:
Between 29 years and 85 years
Trial Updated:
11/12/2024
Locations: PulmonIx, LLC, Greensboro, North Carolina
Conditions: Pulmonary Nodule, Solitary, Lung Cancer
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RRx-001 for Reducing Oral Mucositis in Patients Receiving Chemotherapy and Radiation for Head and Neck Cancer
NCT05966194
Recruiting
The purpose of this study is to determine if RRx-001, which is added on to the cisplatin and radiation treatment, reduces the incidence of severe oral mucositis in patients with head and neck cancers. All patients in this study will receive 7 weeks of standard of care radiation therapy given with the chemotherapy agent, cisplatin. Patients will receive RRx-001 or placebo before start of standard of care treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: East Carolina University School of Medicine, Greenville, North Carolina
Conditions: Oral Mucositis
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Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)
NCT05945355
Recruiting
This is single-center cross-sectional mechanistic study in lean and obese children with moderate-severe asthma, followed by a randomized, SHAM-controlled trial of Inspiratory Training (IT). The primary outcome is to describe the contributions of inspiratory muscle dysfunction (IMD) and Small Airway Dysfunction (SAD) to obesity-related versus non-obesity-related asthma. The study will involve training (IT) for 8 weeks at three intensity levels (SHAM, low and high). Target dose: 150 inspirations t... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
11/12/2024
Locations: Duke Health Center Creekstone, Durham, North Carolina
Conditions: Asthma in Children, Obesity, Pediatric Obesity, Pediatric Asthma
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Incremental Hemodialysis: The TwoPlus Trial
NCT05828823
Recruiting
This study is to prospectively compare clinical effectiveness between clinically- matched incremental hemodialysis and conventional hemodialysis in patients with incident kidney dysfunction requiring dialysis and residual kidney function. The study will enroll 350 patients on chronic hemodialysis and 140 caregivers of enrolled patients. Patients will be randomized in 1:1 ratio to either incremental start hemodialysis or conventional hemodialysis. Caregivers will be followed along with patients... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: University of North Carolina Chapel Hill, Chapel Hill, North Carolina
Conditions: End-Stage Kidney Disease
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Finger Movement Training After Stroke
NCT05621980
Recruiting
Human development as a species has been strongly associated with the ability to dexterously manipulate objects and tools. Unfortunately, current therapy efforts typically fail to restore fine manual control after stroke. The goal of this study is to evaluate a new intervention that would combine targeted electrical stimulation of selected nerves with use a soft, pneumatically actuated hand exoskeleton to enhance repetitive practice of independent movements of the fingers and thumb in order to im... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/12/2024
Locations: Hand Rehabilitation Lab, Raleigh, North Carolina
Conditions: Stroke
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Inspiratory Pulmonary Rehabilitation for Children With Obesity and Asthma
NCT05608668
Recruiting
This is a single-center, randomized, SHAM-controlled, parallel assignment, double-masked,8-week interventional study among children aged 8-17 years (not yet 18 years old) of age with obesity and asthma. (n=60), recruited from Duke Health Center Creekstone, to test the effectiveness of inspiratory muscle rehabilitation (IMR) as an acceptable add-on intervention to reduce dyspnea (feeling short-of-breath or breathless) and to promote greater activity in children with obesity and asthma. Clinic to... Read More
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
11/12/2024
Locations: Duke Healthy Lifestyles Clinic, Durham, North Carolina
Conditions: Pediatric Obesity, Pediatric Asthma
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IL13 Signaling in Allergic Asthma
NCT05478824
Recruiting
This study will investigate the role of dupilumab in the treatment of asthma with comorbid obesity. It is hypothesized that in airway epithelial cells, unique transcriptomic and proteomic expression patterns distinguish allergic and non-allergic patients with asthma and obesity and drive significant differential responses to dupilumab. It is further hypothesized that dupilumab will increase interleukin-13 receptor alpha 2 (IL-13Rα2) levels and/or signaling activity on airway epithelial cells iso... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/12/2024
Locations: Duke Asthma Allergy and Airway Center, Durham, North Carolina
Conditions: Asthma, Allergic, Asthma, Obesity
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High Dose Inspiratory Muscle Training in LOPD
NCT05431127
Recruiting
Study Objectives: 1) assess the safety and feasibility of high-dose inspiratory muscle training (IMT) delivered remotely in Late-onset Pompe Disease (LOPD) and 2) determine its effects on respiratory and patient-reported outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Late-Onset Pompe Disease, Lysosomal Disease
Register for Updates