North Carolina is currently home to 2640 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)
NCT05329649
Recruiting
This is a single-dose, open-label study in pediatric participants with severe SCD and hydroxyurea (HU) failure or intolerance. The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells (hHSPCs) (CTX001).
Gender:
ALL
Ages:
Between 2 years and 11 years
Trial Updated:
10/16/2024
Locations: Atrium Health Levine Children's Hospital, Charlotte, North Carolina
Conditions: Sickle Cell Disease, Hydroxyurea Failure, Hydroxyurea Intolerance, Hemoglobinopathies, Hematological Diseases
Register for Updates
Study of ORIC-114 in Patients with Advanced Solid Tumors Harboring an EGFR or HER2 Alteration
NCT05315700
Recruiting
The purpose of this study is to establish the recommended Phase 2 dose (RP2D) and/or maximum tolerated dose (MTD), safety, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of ORIC-114 as a Single Agent or in Combination with Chemotherapy when administered to patients with advanced solid tumors harboring an EGFR or HER2 alteration.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/16/2024
Locations: Duke Cancer Institute, Durham, North Carolina
Conditions: Solid Tumors
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Long-term Outcomes of Complex Conversion Total Hip Arthroplasty
NCT06533020
Recruiting
The purpose of the research study is to examine the long-term outcomes of complex and conversion total hip arthroplasty procedures. By means of both retrospective (chart review) and prospective (in-person clinic visits) radiographs and validated patient-reported outcome scores including the Hip Disability and Osteoarthritis Outcome Score (HOOS) and the Patient-Reported Outcomes Measurement Information System (PROMIS), the research team aims to collect, analyze, and summarize the outcome data. Th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Arthroplasty Complications
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Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD
NCT05566769
Recruiting
NMOSDCopilot is a digital tool developed for the self-assessment of Neuromyelitis Optica Spectrum Disorder symptoms that impact patients' functioning and quality of life. It has been co-designed with the help of patient advocacy groups, NMOSD patients and medical experts. It includes a smartphone-based application for patients, connected to a web portal developed for healthcare professionals (HCSPs). The patient application is composed of vision, walking, cognition, and dexterity e-active tests... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/14/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Neuromyelitis Optica
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GWICTIC: NAC Mechanistic Study in Gulf War Veterans
NCT04987775
Recruiting
This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.
Gender:
ALL
Ages:
Between 47 years and 70 years
Trial Updated:
10/11/2024
Locations: RTI International, Durham, North Carolina
Conditions: Gulf War Syndrome
Register for Updates
Janus Feasibility Study
NCT03985527
Recruiting
The purpose of this feasibility study is to assess whether an alternative transvenous lead location affects respiration and airway physiology during a commercial remedē® System or commercial transvenous cardiac device (de novo pacemaker or implantable cardiac defibrillator) implant procedure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2024
Locations: Novant Health Forsyth Medical Center, Winston-Salem, North Carolina
Conditions: Sleep Apnea Syndromes
Register for Updates
Nafamostat Efficacy in Phase 3 Registrational CRRT Study
NCT06150742
Recruiting
A prospective, randomized, placebo-controlled clinical study to investigate the safety and efficacy of Niyad (nafamostat mesylate) for anticoagulation of extracorporeal blood circulating through a dialysis filter in patients undergoing CRRT who cannot tolerate heparin or are at higher risk for bleeding.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/10/2024
Locations: Wake Forest, Winston-Salem, North Carolina
Conditions: Acute Kidney Injury
Register for Updates
ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials
NCT06141993
Recruiting
This study will follow men with metastatic castration resistant prostate cancer throughout their standard of care treatment for their disease to determine if the presence of different genes or proteins can predict which patients respond to the cancer treatment they receive. As tumors grow and begin to spread, they may release cells into patients' bloodstream. These cells are called "circulating tumor cells", or CTCs. CTCs can be used to look for differences in "biomarkers" (genes or proteins tha... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
10/10/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Metastatic, Castration-resistant Prostate Cancer
Register for Updates
UNC Pleural Fluid Registry
NCT05620329
Recruiting
Research with biospecimens such as blood, tissue, or body fluids can help researchers understand how the human body works. Researchers can make new tests to find diseases, understand how treatments work, or find new ways to treat a disease. The purpose of this study is to collect biospecimens for research from patients with known or suspected lung cancer. The information learned from the biospecimens may be used in future treatments. The purpose of this protocol is to create a pleural fluid regi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/10/2024
Locations: UNC Lingeberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Conditions: Lung Cancer, Lung Infection, Breast Cancer, Malignant Pleural Effusion, Empyema
Register for Updates
Impella RP Flex with Smart Assist
NCT06637644
Recruiting
To capture observational data of the Abiomed Impella RP Flex in a real-world setting.
Gender:
ALL
Ages:
All
Trial Updated:
10/09/2024
Locations: Novant Health New Hanover Regional Medical Center, Wilmington, North Carolina
Conditions: Right Ventricular (RV) Dysfunction
Register for Updates
A Study of Mosliciguat in PH-ILD
NCT06635850
Recruiting
This is a Phase 2, randomized, double-blind, placebo-controlled, multi-center clinical study to evaluate the safety and efficacy of inhaled mosliciguat in participants with pulmonary hypertension associated with interstitial lung disease (PH-ILD).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/09/2024
Locations: PulmonIx, Greensboro, North Carolina
Conditions: Pulmonary Hypertension, Interstitial Lung Disease, Lung Diseases, Vascular Diseases, Cardiovascular Diseases, Fibrosis
Register for Updates
Flexibility, Alcohol Misuse, and Excitation
NCT06634771
Recruiting
The goal of this study is to learn whether a single non-invasive brain stimulation alpha-transcranial alternating current stimulation (alpha-tACS) session changes measures of excitability in the prefrontal cortex. It will also learn whether these changes predict differences in habitual action selection in a laboratory task and whether the effects depend on alcohol use history. The main questions it aims to answer are: Does alpha-tACS reduce habitual action selection by reducing excitability in... Read More
Gender:
ALL
Ages:
Between 22 years and 50 years
Trial Updated:
10/09/2024
Locations: University of North Carolina, Chapel Hill, Chapel Hill, North Carolina
Conditions: Behavioral Flexibility, Healthy Volunteers, High Risk Alcohol Use
Register for Updates