North Carolina is currently home to 2640 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Little Cigar and Cigarillo Warnings to Reduce Tobacco-Related Cancers and Disease - Eye Tracking
NCT06546618
Recruiting
The goal of this research is to determine how removal of little cigar and cigarillo (LCC) flavor descriptors on packaging impacts attention and affective responses to LCC warnings. A study will be conducted using eye tracking, electrodermal activity (galvanic skin response), and survey measures of affect to measure participant responses to LCC packages varied by warning type (pictorial vs. text only) and flavor contents ('Sweet' flavor descriptor vs. no flavor descriptor).
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/09/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Tobacco Use
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Mobile Neurofeedback for Low Back Pain
NCT05669027
Recruiting
The purpose of this study is to learn more about improving the quality of treatments for people who have chronic low back pain. Participants will complete interviews with Duke researchers at four different time points: the beginning of the study, at 3 months, at 6 months, and at 9 months. Participants will be asked to use a mobile app and a headset that are designed to train the brain to be more relaxed. Participants will use the mobile app for 10 minutes at a time, four times a week for three m... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
10/09/2024
Locations: Duke University Medical Center, Department of Psychiatry, Durham, North Carolina
Conditions: Chronic Low Back Pain
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Extubation Criteria in Patients Greater Than 59 Years of Age
NCT04596735
Recruiting
Prospectively evaluate the predictive value of individual pre-specified clinical extubation criteria for extubation success
Gender:
ALL
Ages:
60 years and above
Trial Updated:
10/09/2024
Locations: Wake Forest Health Sciences, Winston-Salem, North Carolina
Conditions: Extubation, Respiratory Complications
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Nature IDEAS Study: an RCT to Increase Time Spent in Nature Among University Students
NCT06633367
Recruiting
This project will first examine nature opportunities, belonging and benefits with a multi-state nature-based intervention with a focus on students of color. In light of the syndemic, 'nature deficit disorder' and poor mental health, the investigators anticipate several far-reaching impacts that will (a) test a nationally useful standardized way to quantify exposure; (b) invest in nature resources and accessibility on campuses; and (c) promote the mental health and therapeutic benefits of nature... Read More
Gender:
ALL
Ages:
Between 18 years and 24 years
Trial Updated:
10/08/2024
Locations: North Carolina A&T University, Greensboro, North Carolina
Conditions: Mental Health
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Optimize Pediatric OCT Imaging
NCT06139523
Recruiting
Handheld optical coherence tomography (OCT) has become an important imaging modality to evaluate the pediatric retina. The objective of this pilot study is to compare a new contact OCT system (Theia Imaging) with an investigational noncontact OCT system (Duke Biomedical Engineering) to assess their ability to image the pediatric retina. The investigators hypothesize that the contact OCT system is superior in imaging larger areas of the retina (larger field-of-view), while it has similar resolut... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/08/2024
Locations: Duke University Eye Center, Durham, North Carolina
Conditions: Retinal Disease, Glaucoma, Optic Nerve Diseases
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Sling vs No Sling After Reverse Total Shoulder Arthroplasty
NCT06092996
Recruiting
This study involves patients who will be undergoing a reverse total shoulder replacement at Duke University. 100 eligible will be randomly assigned into one of two groups, a sling or no sling group. Patients in the sling group will wear a sling for three weeks after their surgery while the no sling group will only wear a sling three days after their surgery. Patients will follow their doctors normal follow up visit schedule after surgery, with visits at 2 weeks, 6 weeks, 3 months, 6 months, 1 ye... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
10/08/2024
Locations: Duke University, Durham, North Carolina
Conditions: Shoulder Disease, Rotator Cuff Tear Arthropathy, Shoulder Osteoarthritis
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Imaging Retinal Vasculature in Infant Eyes
NCT05558059
Recruiting
Retinopathy of prematurity is a leading cause of childhood blindness worldwide. The fovea, a critical location in the retina determining visual acuity and visual function, and the blood vessels around it, are abnormally developed in infants with retinopathy of prematurity. However, how these blood vessels form during development of the human fovea remains unclear. This research will advance our understanding of the fundamental knowledge of how the blood vessels around the fovea form in infants,... Read More
Gender:
ALL
Ages:
2 months and below
Trial Updated:
10/08/2024
Locations: Duke University, Durham, North Carolina
Conditions: Retinopathy of Prematurity
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Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
NCT05055830
Recruiting
OPTIC is a prospective, open-label, non-randomized study of multiple medications administered to approximately 2000 children in the pediatric cardiac intensive care unit (PCICU) per routine clinical car by their treating provider. The purpose of this study is to characterize the PK of drugs routinely administered to children per standard of care using opportunistic and scavenged samples. The prescribing of drugs to children will not be part of this protocol. After the child/adult (\<21 years of... Read More
Gender:
ALL
Ages:
Between 0 months and 20 years
Trial Updated:
10/08/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Cardiac Disease, Critically Ill, Children, Adult
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Open Versus Arthroscopic Stabilization of Shoulder Instability with Subcritical Bone Loss: the OASIS Trial
NCT04809064
Recruiting
This clinical trial will investigate the effects of three surgical procedures and the associated post-operative rehabilitation to optimize time to return to military duty, work and sports, and patient-reported physical function for military personnel and civilians with traumatic anterior shoulder instability and 10-20% glenoid bone loss.
Gender:
ALL
Ages:
Between 17 years and 50 years
Trial Updated:
10/08/2024
Locations: Naval Medical Center Camp Lejeune, Camp Lejeune, North Carolina
Conditions: Shoulder Dislocation, Glenohumeral Dislocation, Anterior Shoulder Dislocation
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Longitudinal Assessment of Marrow and Blood in Patients With Glioblastoma
NCT04657146
Recruiting
The main goal of this study is to provide foundational data to drive translational approaches for an entirely novel category of immunotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/08/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Glioblastoma
Register for Updates
Written Exposure Therapy to Improve Recovery Among Sexual Assault Survivors
NCT06571513
Recruiting
The main objective of this pilot trial is to determine the feasibility and initial efficacy of telehealth-delivered written exposure therapy to reduce the development of posttraumatic stress disorder after sexual assault. This pilot trial will provide the data necessary to design and support a large-scale trial.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Post-traumatic Stress Disorder
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Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART
NCT06405373
Recruiting
This study is designed to compare two behavioral approaches to reduce diabetes distress ("the expected burdens, concerns, fears, and threats that arise from the challenges of living with diabetes") in adults with type 1 diabetes. At the study baseline, participants will be randomized to take part in one of two virtual, group-based interventions (the "Primary" intervention) utilizing either an emotions-focused or a problem-solving approach to reduce diabetes distress. After the initial interventi... Read More
Gender:
ALL
Ages:
30 years and above
Trial Updated:
10/07/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Diabetes type1, Diabetes Mellitus, Type 1, Diabetes, Autoimmune, Diabetes Mellitus, Distress, Emotional
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