North Carolina is currently home to 2640 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Randomized Study of the pdSTIM™ System (Phrenic Nerve to Diaphragm STIMulation) in Failure to Wean Mechanically Ventilated Patients
NCT05998018
Recruiting
This prospective, multi-center, randomized, controlled clinical trial is being conducted to evaluate the safety and efficacy of the pdSTIM System to facilitate weaning from mechanical ventilation through phrenic nerve stimulation. Potential subjects who are on mechanical ventilation for at least four days and have failed at least one weaning attempt will be considered for the study. Those enrolled will be randomized in a 1:1 manner between the treatment group that is standard of care with the pd... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/03/2024
Locations: Atrium Health, Charlotte, North Carolina
Conditions: Ventilator Induced Diaphragm Dysfunction
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JuggerStitch Post Market Clinical Follow-up Study
NCT04228367
Recruiting
This study is a post-market follow-up study. The data collected from this study will serve the purpose of confirming the safety and performance of the JuggerStitch Device used for meniscal repair according to the product labelling (Instruction For Use).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/03/2024
Locations: OrthoCarolina, Charlotte, North Carolina
Conditions: Meniscus Tear, Tibial, Meniscus Lesion
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Neuroblastoma Biology Study
NCT01587300
Recruiting
Medical scientists want to find better ways to treat neuroblastoma and to find ways to prevent the tumor from growing back. To do this, they need more information about the characteristics of neuroblastoma cells. Therefore, they want to study samples of neuroblastoma tissues and neuroblastoma and normal cells in the blood and bone marrow that may be related to the growth of neuroblastoma cells. Doctors and other medical scientists also want to find better ways to detect and measure neuroblastoma... Read More
Gender:
ALL
Ages:
Between 31 days and 99 years
Trial Updated:
09/01/2024
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Neuroblastoma
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Regulating Blood Pressure During Recovery from Intracerebral Hemorrhage and Ischemic Stroke
NCT04760717
Recruiting
The purpose of this research study is to determine whether blood pressure treatment regimens with spironolactone are better than blood pressure treatment regimens without spironolactone at lowering blood pressure in stroke survivors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/30/2024
Locations: Wake Forest Baptist Health, Winston-Salem, North Carolina
Conditions: Intracerebral Hemorrhage, Spironolactone, Ischemic Stroke
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Pain Effect on Attention Using an Ipad Game App
NCT03115788
Recruiting
Cognitive performance will be studied over time using an iPad game interface called the nine choice human game (5CH) in normal volunteer subjects before during and after experimentally induced thermal (cold or warm) pain or control (no intervention).
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/30/2024
Locations: Wake Forest University School of Medicine, Winston-Salem, North Carolina
Conditions: Cognitive Function
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Detection of Brown Adipose Tissue by Magnetic Resonance Imaging
NCT02237872
Recruiting
The primary goal of this study is to assess the accuracy of conventional fat fraction proton MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using 18F-2-fluoro-2-deoxy-D-glucosefluorodeoxyglucose -PET as gold standard. In this pilot study, MRI and PET imaging of BAT of healthy adult volunteers will be performed on a combined PET/MRI scanner under mild cold condition.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/30/2024
Locations: Biomedical Research Imaging Center, Chapel Hill, North Carolina
Conditions: Obesity
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Hyperpolarized Xenon-129 Magnetic Resonance Imaging and Spectroscopy of Brown Fat: Healthy Adult Volunteer Pilot Study
NCT02220426
Recruiting
The primary goal of this study is to evaluate the feasibility of detecting Brown Adipose Tissue (BAT) in healthy subjects by using hyperpolarized xenon gas MRI. In this pilot study, MRI of BAT of healthy adult volunteers will be performed at 3 Tesla to assess image quality using a prototype surface coil and pulse sequence following inhalation of hyperpolarized 129Xe (xenon) gas at thermoneutrality and under mild cold condition. The investigators are testing the abilities of xenon MRI to see br... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
08/30/2024
Locations: Biomedical Research Imaging Center, Chapel Hill, North Carolina
Conditions: Obesity
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A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Patients With HER2-Positive Advanced Solid Tumors
NCT05593094
Recruiting
This will be a Phase 1, multicenter, open-label trial to evaluate the safety, tolerability, PK and efficacy of ZN-A-1041 as a monotherapy or in combination in patients with HER2-positive advanced solid tumors with or without brain metastases. The study will consist of three phases: Phase 1a (dose escalation with ZN-A-1041 monotherapy), Phase 1b (dose escalation with ZN-A-1041 combination therapy) and Phase 1c (dose expansion with ZN-A-1041 combination therapy).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/29/2024
Locations: Duke Cancer Institute, Durham, North Carolina
Conditions: Advanced Solid Tumors, HER2-positive Breast Cancer
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Genomics in Michigan to AdJust Outcomes in Prostate canceR (G-MAJOR) for Men With Newly Diagnosed Favorable Risk Prostate Cancer
NCT04396808
Recruiting
This study seeks to determine the clinical impact of Gene Expression Classifier (GEC) testing in prostate cancer care while also developing a pragmatic approach for improved GEC clinical use and future study.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/29/2024
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Prostate Cancer
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CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) Study
NCT06096675
Recruiting
Exercise training in patients with heart failure and preserved ejection fraction (HFpEF) has been associated with an improvement in cardiorespiratory fitness and quality of life.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2024
Locations: Sanger Heart and Vascular Institute, Charlotte, North Carolina
Conditions: Cardiac Amyloidosis
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Early Patient Removal of Urinary Catheters After Urogynecologic Surgery
NCT06344884
Recruiting
Management of postoperative urinary retention often requires the use of indwelling catheters. In a previous study, the investigators determined that patient removal of catheters at home is non-inferior to standard office removal on postoperative day three or four (POD3-4). The purpose of this study is to determine whether patient removal of catheters at home on postoperative day one (POD1) is noninferior to removal on POD 3-4.
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
08/27/2024
Locations: UNC Health Rex, Raleigh, North Carolina
Conditions: Urinary Retention Postoperative, Postoperative Urinary Tract Infection, Catheter Site Pain
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A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer
NCT06067841
Recruiting
The purpose of this study is to assess the safety, tolerability, and preliminary efficacy of BMS-986460 in men with Metastatic Castration-resistant Prostate Cancer.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/27/2024
Locations: Duke Cancer Institute, Durham, North Carolina
Conditions: Metastatic Castration-resistant Prostate Cancer
Register for Updates