North Carolina is currently home to 2644 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Quantitation and Spatial Registration of Airways Dysfunction With Dynamic 19F MRI in Cystic Fibrosis
NCT06057714
Recruiting
The purpose of this study is to look at lung ventilation in people with cystic fibrosis over time (1 year) using magnetic resonance imaging (MRI) with an inhaled contrast gas, and compare these measures to lung function assessed by spirometry and multiple breath nitrogen washout. This study also looks at how these measures change in response to a pulmonary exacerbation and treatment (if applicable). Over the span of a year, participants would be asked to complete 3-5 visits to the University of... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
10/16/2024
Locations: Univeristy of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Cystic Fibrosis, Ventilatory Defect
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Improving the Outcomes of Adolescents With ADHD Via a Pre-visit Question Prompt List/Video Intervention
NCT05835362
Recruiting
The investigators propose to conduct a pilot randomized controlled feasibility trial to evaluate the feasibility and effectiveness of a pre-visit intervention to improve communication about attention deficit hyperactivity disorder. The investigators will enroll 140 English-speaking youth ages 11-17 with an ADHD medical record diagnosis who screen as having predominantly inattentive subtype, hyperactive/impulsive subtype, or combined inattention/hyperactivity on the Vanderbilt parent assessment s... Read More
Gender:
ALL
Ages:
Between 11 years and 17 years
Trial Updated:
10/16/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: ADHD
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Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)
NCT05329649
Recruiting
This is a single-dose, open-label study in pediatric participants with severe SCD and hydroxyurea (HU) failure or intolerance. The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells (hHSPCs) (CTX001).
Gender:
ALL
Ages:
Between 2 years and 11 years
Trial Updated:
10/16/2024
Locations: Atrium Health Levine Children's Hospital, Charlotte, North Carolina
Conditions: Sickle Cell Disease, Hydroxyurea Failure, Hydroxyurea Intolerance, Hemoglobinopathies, Hematological Diseases
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Long-term Outcomes of Complex Conversion Total Hip Arthroplasty
NCT06533020
Recruiting
The purpose of the research study is to examine the long-term outcomes of complex and conversion total hip arthroplasty procedures. By means of both retrospective (chart review) and prospective (in-person clinic visits) radiographs and validated patient-reported outcome scores including the Hip Disability and Osteoarthritis Outcome Score (HOOS) and the Patient-Reported Outcomes Measurement Information System (PROMIS), the research team aims to collect, analyze, and summarize the outcome data. Th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Arthroplasty Complications
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Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD
NCT05566769
Recruiting
NMOSDCopilot is a digital tool developed for the self-assessment of Neuromyelitis Optica Spectrum Disorder symptoms that impact patients' functioning and quality of life. It has been co-designed with the help of patient advocacy groups, NMOSD patients and medical experts. It includes a smartphone-based application for patients, connected to a web portal developed for healthcare professionals (HCSPs). The patient application is composed of vision, walking, cognition, and dexterity e-active tests... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/14/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Neuromyelitis Optica
Register for Updates
Janus Feasibility Study
NCT03985527
Recruiting
The purpose of this feasibility study is to assess whether an alternative transvenous lead location affects respiration and airway physiology during a commercial remedē® System or commercial transvenous cardiac device (de novo pacemaker or implantable cardiac defibrillator) implant procedure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2024
Locations: Novant Health Forsyth Medical Center, Winston-Salem, North Carolina
Conditions: Sleep Apnea Syndromes
Register for Updates
Nafamostat Efficacy in Phase 3 Registrational CRRT Study
NCT06150742
Recruiting
A prospective, randomized, placebo-controlled clinical study to investigate the safety and efficacy of Niyad (nafamostat mesylate) for anticoagulation of extracorporeal blood circulating through a dialysis filter in patients undergoing CRRT who cannot tolerate heparin or are at higher risk for bleeding.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/10/2024
Locations: Wake Forest, Winston-Salem, North Carolina
Conditions: Acute Kidney Injury
Register for Updates
ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials
NCT06141993
Recruiting
This study will follow men with metastatic castration resistant prostate cancer throughout their standard of care treatment for their disease to determine if the presence of different genes or proteins can predict which patients respond to the cancer treatment they receive. As tumors grow and begin to spread, they may release cells into patients' bloodstream. These cells are called "circulating tumor cells", or CTCs. CTCs can be used to look for differences in "biomarkers" (genes or proteins tha... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
10/10/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Metastatic, Castration-resistant Prostate Cancer
Register for Updates
UNC Pleural Fluid Registry
NCT05620329
Recruiting
Research with biospecimens such as blood, tissue, or body fluids can help researchers understand how the human body works. Researchers can make new tests to find diseases, understand how treatments work, or find new ways to treat a disease. The purpose of this study is to collect biospecimens for research from patients with known or suspected lung cancer. The information learned from the biospecimens may be used in future treatments. The purpose of this protocol is to create a pleural fluid regi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/10/2024
Locations: UNC Lingeberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Conditions: Lung Cancer, Lung Infection, Breast Cancer, Malignant Pleural Effusion, Empyema
Register for Updates
Impella RP Flex with Smart Assist
NCT06637644
Recruiting
To capture observational data of the Abiomed Impella RP Flex in a real-world setting.
Gender:
ALL
Ages:
All
Trial Updated:
10/09/2024
Locations: Novant Health New Hanover Regional Medical Center, Wilmington, North Carolina
Conditions: Right Ventricular (RV) Dysfunction
Register for Updates
Flexibility, Alcohol Misuse, and Excitation
NCT06634771
Recruiting
The goal of this study is to learn whether a single non-invasive brain stimulation alpha-transcranial alternating current stimulation (alpha-tACS) session changes measures of excitability in the prefrontal cortex. It will also learn whether these changes predict differences in habitual action selection in a laboratory task and whether the effects depend on alcohol use history. The main questions it aims to answer are: Does alpha-tACS reduce habitual action selection by reducing excitability in... Read More
Gender:
ALL
Ages:
Between 22 years and 50 years
Trial Updated:
10/09/2024
Locations: University of North Carolina, Chapel Hill, Chapel Hill, North Carolina
Conditions: Behavioral Flexibility, Healthy Volunteers, High Risk Alcohol Use
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Little Cigar and Cigarillo Warnings to Reduce Tobacco-Related Cancers and Disease - Eye Tracking
NCT06546618
Recruiting
The goal of this research is to determine how removal of little cigar and cigarillo (LCC) flavor descriptors on packaging impacts attention and affective responses to LCC warnings. A study will be conducted using eye tracking, electrodermal activity (galvanic skin response), and survey measures of affect to measure participant responses to LCC packages varied by warning type (pictorial vs. text only) and flavor contents ('Sweet' flavor descriptor vs. no flavor descriptor).
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/09/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Tobacco Use
Register for Updates