North Carolina is currently home to 2641 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Tamibarotene Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome
NCT04797780
Recruiting
This study compares the efficacy of Tamibarotene in combination with azacitidine to azacitidine in combination with placebo in participants who are Retinoic Acid Receptor Alpha (RARA) positive, and newly diagnosed with higher-risk myelodysplastic syndrome (HR-MDS), and who have not received treatment for this diagnosis. The primary goal of the study is to compare the complete remission rate between the two treatment arms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: Novant Health Inc, Charlotte, North Carolina
Conditions: Myelodysplastic Syndromes
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Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms
NCT04858256
Recruiting
The main purpose of this study is to determine the effectiveness of the study drug pacritinib in people with relapsed or refractory lymphoproliferative disorders.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: Duke Cancer Institute, Durham, North Carolina
Conditions: T-Cell Neoplasm, Lymphoproliferative Disorders
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Healthy Heart Habits-2
NCT06440278
Recruiting
Sixty adults who have experienced acute coronary syndrome within the past 2-12 months from three states (Rhode Island, North Carolina, Minnesota) will be randomized to either (1) a coaching program for depressed mood and health behavior change (Behavioral Activation for Health and Depression; BA-HD), or (2) Enhanced Usual Care. This study will evaluate the feasibility and acceptability of study procedures and BA-HD, and establish protocol and measurement harmonization across three sites in prepa... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/05/2024
Locations: ECU Health, Greenville, North Carolina
Conditions: Acute Coronary Syndrome
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Cardiovascular Effects of Very Low Nicotine Content Cigarettes
NCT05707871
Recruiting
The study is measuring Cardiovascular effects of very low nicotine content cigarettes on daily and non-daily smokers
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/05/2024
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Tobacco Use
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Patient Specific Talus Spacer Post Approval Study
NCT05364606
Recruiting
Humanitarian Device Exemption Approved Patient Specific Talus Spacer Post Approval Study.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/05/2024
Locations: Duke Orthopeadics Arringdon, Morrisville, North Carolina
Conditions: Avascular Necrosis of the Talus
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NC Works4Health: Reducing Chronic Disease Risks in Socioeconomically Disadvantaged, Unemployed Populations
NCT04815278
Recruiting
The proposed study, NC Works4Health (NCW4H), builds on the strengths of long-standing academic-community research partnerships between this UNC at Chapel Hill (UNC) team of investigators and key stakeholders across health, social service, employment, and economic development sectors. The overall goal of this study is to test the effectiveness of a multilevel intervention that can be readily adopted by communities to reduce chronic disease risks in socioeconomically disadvantaged populations by (... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
11/05/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Diabetes, Chronic Disease, Psychological Distress
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Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN
NCT06527872
Recruiting
The purpose of the OBSErve-LN study is to assess the real-world use and effectiveness of belimumab in routine practice for the treatment of adults with active LN in multiple countries of interest. This study aims to provide the first long-term (up to 5 years) assessment of renal function preservation in belimumab treated participants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: GSK Investigational Site, Charlotte, North Carolina
Conditions: Lupus Nephritis
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REvision of VSG with Ablation of the Mucosa Procedure
NCT06671119
Recruiting
The purpose of this study is to evaluate the feasibility, safety, and tolerability of endoscopic selective gastric mucosal ablation (GMA) using argon plasma coagulation after sleeve gastrectomy. In this study, GMA will be performed on patients who have experienced weight regain following an initial successful response to sleeve gastrectomy.
Gender:
ALL
Ages:
Between 22 years and 60 years
Trial Updated:
11/01/2024
Locations: True You Weight Loss, Cary, North Carolina
Conditions: Obesity and Obesity-related Medical Conditions, Obesity and Overweight, Obesity Prevention, Obesity Recidivism
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Trial of an Inactivated Chikungunya Virus Vaccine
NCT06669208
Recruiting
This trial will be a randomized, placebo controlled, double-blind (within dosing group), dose escalation Phase 1 trial, evaluating dosages of 2.5 mcg and 8 mcg of HydroVax-005 CHIKV vaccine given intramuscularly on Day 1 and Day 29 in up to 48 healthy adults healthy adults ≥ 18 and \< 50 years of age. The primary objective is to assess the safety and reactogenicity of the HydroVax-005 CHIKV vaccine administered intramuscularly in a two-dose series on Days 1 and 29 at a dose of 2.5 mcg or a dose... Read More
Gender:
ALL
Ages:
Between 18 years and 49 years
Trial Updated:
11/01/2024
Locations: Duke University Health System, Durham, North Carolina
Conditions: Chikungunya Fever, Chikungunya Virus, Chikungunya
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ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC
NCT05682443
Recruiting
In this Phase 2 study, mCRPC patients with PSMA positive scans who progressed on prior ARTA and up to 2 lines of taxanes, and are naïve to lutetium Lu 177 vipivotide tetraxetan, will be enrolled. The study is open-label, randomized with active control, multi-center study.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: University of North Carolina Cancer Center - 1608, Chapel Hill, North Carolina
Conditions: Metastatic Castration-resistant Prostate Cancer
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Single Position Spine Surgery Registry
NCT04839783
Recruiting
The purpose of this study is to systematically, prospectively compare surgical fusion techniques for thoracolumbar spinal fusion patients and assess long-term patient outcomes and revision rates following surgery.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
11/01/2024
Locations: Atlantic Neurosurgical and Spine Specialists, Wilmington, North Carolina
Conditions: Spine Fusion, Spinal Stenosis, Degenerative Disc Disease
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Immersive Healing: The Therapeutic Potential of Virtual Reality
NCT06077227
Recruiting
Phantom limb pain (PLP) is a significant and pervasive issue among upper limb amputees, severely impacting their quality of life. The literature delineating prevalence of upper versus lower limb amputations is limited, but the prevalence of total amputations in the United States is estimated to reach 3 million individuals by 2050, with approximately 185,000 new cases annually. PLP affects 60-68% of these patients, leading to heightened levels of anxiety, depression, and reduced overall well-bein... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2024
Locations: OrthoCarolina Hand Center, Charlotte, North Carolina
Conditions: Phantom Limb Pain (PLP)
Register for Updates