North Carolina is currently home to 2622 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer
NCT05168566
Recruiting
This is a Phase 2b, multicenter, open-label study to evaluate the safety and efficacy of Sutetinib Maleate Capsule in Locally Advanced or Metastatic NSCLC (Non-resistant Uncommon EGFR Mutations Only, Including L861Q, G719X, and/or S768I)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/21/2024
Locations: FirstHealth Cancer Center, Pinehurst, North Carolina
Conditions: Non-small Cell Lung Cancer
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A Phase 2a Study of IV BCV in Subjects With Adenovirus Infection
NCT04706923
Recruiting
The purpose of this study is to determine the safety and tolerability of intravenous (IV) brincidofovir (BCV; SyB V-1901) 0.2 mg/kg, 0.3 mg/kg or 0.4 mg/kg dosed twice weekly (BIW) or 0.4 mg/kg dosed once weekly (QW) for 4 weeks in subjects with AdV, and IV BCV in subjects with CMV
Gender:
ALL
Ages:
2 months and above
Trial Updated:
06/20/2024
Locations: Research Site, Durham, North Carolina
Conditions: Adenovirus Infections, Cytomegalovirus Infection
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Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma
NCT05433142
Recruiting
The purpose of this study is to assess the safety and tolerability of XmAb®819 administered intravenous (IV) or subcutaneous (SC) in subjects with relapsed or refractory clear cell renal cell carcinoma and to identify the minimum safe and biologically active dose and the recommended dose (RD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: Duke University, Durham, North Carolina
Conditions: Clear Cell Renal Cell Carcinoma
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Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)
NCT05382208
Recruiting
The purpose of this study is to determine if doxycycline will reduce progression of emphysema in people living with HIV. The secondary objectives are to examine the effects of doxycycline on change in quantity of emphysema, six minute walk distance, patient reported outcomes, ratio of forced expiratory volume in 1 second and forced vital capacity. Secondary objectives will also describe the safety and tolerability of doxycycline and determine if doxycycline is associated with development of ant... Read More
Gender:
ALL
Ages:
30 years and above
Trial Updated:
06/18/2024
Locations: The University of North Carolina, Chapel Hill, North Carolina
Conditions: Emphysema, HIV
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Improving the Health of Parents and Their Adolescent and Transition-age Youth With Intellectual and Developmental Disabilities
NCT05986305
Recruiting
This study will determine the comparative effectiveness of Go Act, a tailored advocacy curriculum versus Peer parent-directed peer learning for increasing parent activation for parents of youth with intellectual and developmental disabilities. Second, it will determine the comparative effectiveness of the two study arms for improving parent and youth health outcomes while assessing whether parent activation serves as a mechanism that mediates their effects on health outcomes.
Gender:
ALL
Ages:
Between 11 years and 27 years
Trial Updated:
06/17/2024
Locations: Family Medicine at the Mountain Area Health Education Center, Asheville, North Carolina
Conditions: Intellectual Disability
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Mindfulness Program for Adolescents With 22q11DS
NCT05849441
Recruiting
The goal of this study is to evaluate the effectiveness of the Aware Program, an online mindfulness education program, with adolescents with 22q11DS and their parents.
Gender:
ALL
Ages:
Between 12 years and 19 years
Trial Updated:
06/17/2024
Locations: innovation Research & Training, Durham, North Carolina
Conditions: 22Q11 Deletion Syndrome
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Macrophage Regulation of Ozone-Induced Lung Inflammation
NCT05773001
Recruiting
The purpose of this research study to understand how prior respiratory infections affect the susceptibility to lung inflammation following environmental exposures.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/17/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: SARS-CoV-2 Pneumonia
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Expanded Indications in the Pediatric BONEBRIDGE Population
NCT05615649
Recruiting
This study will assess safety and efficacy of the MED-EL BONEBRIDGE Bone Conduction Implant in children under 12 years old with conductive or mixed hearing loss.
Gender:
ALL
Ages:
Between 3 years and 12 years
Trial Updated:
06/17/2024
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Hearing Loss, Conductive, Hearing Loss, Mixed
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Restoration of Normative Postural Control
NCT06452186
Recruiting
The objective of this proposal is to investigate the effects of training to use direct electromyographic (dEMG) control of a powered prosthetic ankle on transtibial amputees'. The aimed questions to answer: 1. whether dEMG control will improve balance and postural stability of amputees, 2. whether dEMG control will lead to more natural neuromuscular control and coordination, 3) whether dEMG control will reduce cognitive processes. Participants will go through PT guided training on using dEMG... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/14/2024
Locations: North Carolina State University, Raleigh, North Carolina
Conditions: Lower Limb Amputation Below Knee (Injury)
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Ultrasound for Evaluation of Percutaneous G-tube Position
NCT06361498
Recruiting
The goal of this clinical trial is to compare using ultrasound imaging to look at the position of the gastrostomy tube (GT) against fluoroscopic imaging in pediatric patients who had a recent GT tube replacement. The main questions it aims to answer are: * If ultrasound is just as accurate as fluoroscopy to assess the GT position. * If ultrasound takes less time than fluoroscopy to assessing the GT position. Participants will be imaging using ultrasound to assess GT positioning before their s... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
06/14/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Gastrostomy
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A Study to Evaluate Pregnancy Outcomes in Females Treated With Oral Elagolix Tablets and Capsules
NCT04464187
Recruiting
Orilissa is a drug approved for the management of moderate to severe pain associated with endometriosis. Oriahnn is approved for heavy menstrual bleeding due to uterine fibroids. Elagolix-containing products should not be taken by women who are pregnant or suspected to be pregnant but pregnancies are expected as the medicine does not completely stop ovulation and women may inadvertently continue taking Elagolix-containing products until their pregnancy is confirmed. This study will assess pregn... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
06/14/2024
Locations: Iqvia /Id# 240918, Durham, North Carolina
Conditions: Endometriosis, Uterine Fibrioids
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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
NCT04262206
Recruiting
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.
Gender:
ALL
Ages:
75 years and above
Trial Updated:
06/14/2024
Locations: Asheville VA-Charles George VA Medical Center, Asheville, North Carolina
Conditions: Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
Register for Updates