North Carolina is currently home to 2644 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Patient Specific Talus Spacer Post Approval Study
NCT05364606
Recruiting
Humanitarian Device Exemption Approved Patient Specific Talus Spacer Post Approval Study.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/05/2024
Locations: Duke Orthopeadics Arringdon, Morrisville, North Carolina
Conditions: Avascular Necrosis of the Talus
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NC Works4Health: Reducing Chronic Disease Risks in Socioeconomically Disadvantaged, Unemployed Populations
NCT04815278
Recruiting
The proposed study, NC Works4Health (NCW4H), builds on the strengths of long-standing academic-community research partnerships between this UNC at Chapel Hill (UNC) team of investigators and key stakeholders across health, social service, employment, and economic development sectors. The overall goal of this study is to test the effectiveness of a multilevel intervention that can be readily adopted by communities to reduce chronic disease risks in socioeconomically disadvantaged populations by (... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
11/05/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Diabetes, Chronic Disease, Psychological Distress
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Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN
NCT06527872
Recruiting
The purpose of the OBSErve-LN study is to assess the real-world use and effectiveness of belimumab in routine practice for the treatment of adults with active LN in multiple countries of interest. This study aims to provide the first long-term (up to 5 years) assessment of renal function preservation in belimumab treated participants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: GSK Investigational Site, Charlotte, North Carolina
Conditions: Lupus Nephritis
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REvision of VSG with Ablation of the Mucosa Procedure
NCT06671119
Recruiting
The purpose of this study is to evaluate the feasibility, safety, and tolerability of endoscopic selective gastric mucosal ablation (GMA) using argon plasma coagulation after sleeve gastrectomy. In this study, GMA will be performed on patients who have experienced weight regain following an initial successful response to sleeve gastrectomy.
Gender:
ALL
Ages:
Between 22 years and 60 years
Trial Updated:
11/01/2024
Locations: True You Weight Loss, Cary, North Carolina
Conditions: Obesity and Obesity-related Medical Conditions, Obesity and Overweight, Obesity Prevention, Obesity Recidivism
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ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC
NCT05682443
Recruiting
In this Phase 2 study, mCRPC patients with PSMA positive scans who progressed on prior ARTA and up to 2 lines of taxanes, and are naïve to lutetium Lu 177 vipivotide tetraxetan, will be enrolled. The study is open-label, randomized with active control, multi-center study.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: University of North Carolina Cancer Center - 1608, Chapel Hill, North Carolina
Conditions: Metastatic Castration-resistant Prostate Cancer
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Single Position Spine Surgery Registry
NCT04839783
Recruiting
The purpose of this study is to systematically, prospectively compare surgical fusion techniques for thoracolumbar spinal fusion patients and assess long-term patient outcomes and revision rates following surgery.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
11/01/2024
Locations: Atlantic Neurosurgical and Spine Specialists, Wilmington, North Carolina
Conditions: Spine Fusion, Spinal Stenosis, Degenerative Disc Disease
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Immersive Healing: The Therapeutic Potential of Virtual Reality
NCT06077227
Recruiting
Phantom limb pain (PLP) is a significant and pervasive issue among upper limb amputees, severely impacting their quality of life. The literature delineating prevalence of upper versus lower limb amputations is limited, but the prevalence of total amputations in the United States is estimated to reach 3 million individuals by 2050, with approximately 185,000 new cases annually. PLP affects 60-68% of these patients, leading to heightened levels of anxiety, depression, and reduced overall well-bein... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2024
Locations: OrthoCarolina Hand Center, Charlotte, North Carolina
Conditions: Phantom Limb Pain (PLP)
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REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities
NCT06399705
Recruiting
This is a research study in minorities to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented with a small wire mesh tube through a small incision in the wrist or the groin. The other procedure is an open-heart operation in which healthy blood vessels from inside the chest, leg, and/or forearm are used to "bypass" the blockages (like a detour). Outcomes will be measured by comparing survival an... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: Duke University, Durham, North Carolina
Conditions: Coronary Artery Disease
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REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women
NCT06399692
Recruiting
This is a research study in women to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented with a small wire mesh tube through a small incision in the wrist or the groin. The other procedure is an open-heart operation in which healthy blood vessels from inside the chest, leg, and/or forearm are used to "bypass" the blockages (like a detour). Outcomes will be measured by comparing survival and imp... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: Duke University, Durham, North Carolina
Conditions: Coronary Artery Disease
Register for Updates
Targeted Motor Learning to Improve Gait for Individuals With Parkinson Disease
NCT05864157
Recruiting
The purpose of this research study is to determine how training to step with a metronome on both a treadmill, as well as overground, will influence the way that people with Parkinson disease walk. Using metronomes is commonly used in clinics, but the investigators will be using a combination of slow and fast frequencies to alter the way that people walk. The use of a slower frequency metronome on the treadmill is intended to help participants take larger steps. The use of a faster frequency metr... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
10/30/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Parkinson Disease
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LINX Reflux Management System or Fundoplication Clinical Study in Patients With Hiatal Hernia >3 cm
NCT04695171
Recruiting
The cohort registry is both retrospective and prospective, multicenter surveillance of subjects who underwent a prior hiatal hernia repair and Magnetic Sphincter Augmentation or fundoplication construction more than 2 years prior to initial study visit.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/30/2024
Locations: East Carolina University, Greenville, North Carolina
Conditions: Hiatal Hernia Large, Gastro Esophageal Reflux, Hiatal Hernia, Hiatal Hernia, Paraesophageal, Reflux, Gastroesophageal, Reflux Acid
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DermaSensor Postmarket Surveillance Study
NCT06666790
Recruiting
The objective of this study is to evaluate the sensitivity of the DermaSensor device and Investigators when used on skin lesions concerning for melanoma.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
10/29/2024
Locations: West Clinical Research, Morehead City, North Carolina
Conditions: Melanoma, Skin
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