North Carolina is currently home to 2618 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
GSD VI and GSD IX Natural History
NCT04454216
Recruiting
Collection and review of clinical information related to Glycogen Storage Disease Type VI (GSD VI) OR Glycogen Storage Disease Type IX (GSD IX) generated during clinic visits.
Gender:
ALL
Ages:
Between 0 years and 90 years
Trial Updated:
06/05/2024
Locations: Duke University, Durham, North Carolina
Conditions: Glycogen Storage Disease VI, GLYCOGEN STORAGE DISEASE IXa1, GLYCOGEN STORAGE DISEASE IXa2, Glycogen Storage Disease IXB, Glycogen Storage Disease IXC, GSD 9 (All Subtypes), GSD 6
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Functional Assessment in Liver Transplantation
NCT03228290
Recruiting
This will be a prospective cohort study of patients with liver disease. Subjects will undergo geriatric assessments of frailty, functional status, and disability using functional status measures at baseline and at every clinic visit in the pre-transplant setting. Subjects will also answer questions regarding quality of life, personality, and/or cognitive function. Subjects will again undergo assessments at every clinic visit through 12 months after transplant. Then, they will be followed annuall... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/05/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: End Stage Liver Disease
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Conversations You Want About Corona Virus Disease (COVID-19)
NCT05191420
Recruiting
Web-enabled virtual topical guide: develop virtual conversations for each concern and intensity level
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2024
Locations: Wake Forest Health Sciences, Winston-Salem, North Carolina
Conditions: Covid19
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Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study
NCT03144206
Recruiting
A parallel-group randomized pilot trial at a single institution (Duke University) on the effect of postoperative hyperbaric oxygen therapy on wound healing in patients with soft tissue sarcoma undergoing surgical resection with neo-adjuvant radiation therapy.. Participants will be allocated to either the treatment group (HBOT) or control (standard of care) by computer-generated randomization, stratified by tumor size (≤10cm and \>10cm). An unequal randomization of 2:1 will be utilized to provide... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
06/04/2024
Locations: Duke University, Durham, North Carolina
Conditions: Sarcoma, Hyperbaric Oxygen Therapy
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Muscle Fiber Fragment Treatment for Urinary Incontinence
NCT01953263
Recruiting
This study is designed to evaluate the safety of autologous muscle fiber fragments for the treatment of urinary incontinence due to incompetent outlet (bladder neck/urethra).
Gender:
FEMALE
Ages:
Between 18 years and 75 years
Trial Updated:
06/03/2024
Locations: Wake Forest Urology Clinic, Winston-Salem, North Carolina
Conditions: Urinary Incontinence
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PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
NCT05313165
Recruiting
A prospective, single-arm, multi-center study designed to gather additional information on the LimFlow System.
Gender:
ALL
Ages:
Between 18 years and 95 years
Trial Updated:
05/31/2024
Locations: Atrium Health, Charlotte, North Carolina
Conditions: Critical Limb Ischemia, Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia
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Primary Care Implementation and Evaluation of Coach McLungs
NCT05059210
Recruiting
The goal of this study is to evaluate the implementation of the Coach McLungsSM shared decision making (SDM) intervention into primary care across a large healthcare system. Coach McLungsSM is a virtual evidence-based asthma intervention with built-in asthma education and clinical decision support. All asthma patients aged 5-17 who attend these practices will be assessed for uncontrolled asthma. Asthma exacerbations attributed to emergency department visits, hospitalizations, and oral steroid us... Read More
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
05/31/2024
Locations: Atrium Health, Charlotte, North Carolina
Conditions: Asthma
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Wake Forest Alzheimer's Disease Clinical Core
NCT03140865
Recruiting
Efforts to find treatments for AD have yielded only modest benefits, likely because longstanding AD pathological processes induce irreversible neurological compromise. These processes begin years before the onset of clinical symptoms. This possibility has been incorporated into a model describing stages of AD development, articulated by the NIA/Alzheimer's Association preclinical workgroup of which the Co-Director of the Kulynych Alzheimer's Research Center, Dr. Suzanne Craft, was a member. Acco... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
05/30/2024
Locations: Wake Forest Baptist Health, Winston-Salem, North Carolina
Conditions: Alzheimer's Disease, Mild Cognitive Impairment, Prediabetic State
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Open-Label, Dose-Escalation With Expansion to Assess the Safety, Tolerability, and PK of TRE-515 in Subjects With Solid Tumors
NCT05055609
Recruiting
TRE-515 is a first-in-class small molecule inhibitor of deoxycytidine kinase (dCK) that is being developed for oral administration in patients with solid tumors. In cancer cells, rapid and upregulated DNA replication creates high replication stress, as such, cancer cells are more susceptible than normal cells to perturbations in nucleotide metabolism by DNA-targeting treatments such as TRE-515. The Primary objective is too determine the safety and maximum tolerability of TRE-515 when administer... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/29/2024
Locations: Carolina BioOncology Institute, Huntersville, North Carolina
Conditions: Solid Tumor, Adult, Oncology
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A Study of Dapansutrile Plus Pembrolizumab in Patients With PD-1 Refractory Advanced Melanoma
NCT04971499
Recruiting
This phase 1/2 trial will be conducted in two parts. Part 1 (Dose Selection) is designed to find the dose of dapansutrile with acceptable tolerability in combination with pembrolizumab. Part 1 will consist of up to 2 dose selection cohorts to evaluate the safety and tolerability of dapansutrile + pembrolizumab in patients with PD-1 resistant melanoma to find the recommended part 2 dose (RP2D). Part 1 will include a lead-in phase of dapansutrile monotherapy at 500 mg PO BID. At day 15, combinatio... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/29/2024
Locations: Duke Cancer Center, Durham, North Carolina
Conditions: Melanoma
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Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury
NCT04810858
Recruiting
This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.
Gender:
ALL
Ages:
Between 25 years and 59 years
Trial Updated:
05/29/2024
Locations: Biotech Place, Winston-Salem, North Carolina
Conditions: Cannabis, HIV, Inflammation, Cognition, Neuroimaging
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Parkinson's Foundation PD GENEration Genetic Registry
NCT04994015
Recruiting
Development of a central repository for PD-related genomic data for future research.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/28/2024
Locations: University of North Carolina - Chapel Hill, Chapel Hill, North Carolina
Conditions: Parkinson's Disease
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