North Carolina is currently home to 2662 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Detection of Brown Adipose Tissue by Magnetic Resonance Imaging
NCT02237872
Recruiting
The primary goal of this study is to assess the accuracy of conventional fat fraction proton MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using 18F-2-fluoro-2-deoxy-D-glucosefluorodeoxyglucose -PET as gold standard. In this pilot study, MRI and PET imaging of BAT of healthy adult volunteers will be performed on a combined PET/MRI scanner under mild cold condition.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/30/2024
Locations: Biomedical Research Imaging Center, Chapel Hill, North Carolina
Conditions: Obesity
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Hyperpolarized Xenon-129 Magnetic Resonance Imaging and Spectroscopy of Brown Fat: Healthy Adult Volunteer Pilot Study
NCT02220426
Recruiting
The primary goal of this study is to evaluate the feasibility of detecting Brown Adipose Tissue (BAT) in healthy subjects by using hyperpolarized xenon gas MRI. In this pilot study, MRI of BAT of healthy adult volunteers will be performed at 3 Tesla to assess image quality using a prototype surface coil and pulse sequence following inhalation of hyperpolarized 129Xe (xenon) gas at thermoneutrality and under mild cold condition. The investigators are testing the abilities of xenon MRI to see br... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
08/30/2024
Locations: Biomedical Research Imaging Center, Chapel Hill, North Carolina
Conditions: Obesity
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A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Patients With HER2-Positive Advanced Solid Tumors
NCT05593094
Recruiting
This will be a Phase 1, multicenter, open-label trial to evaluate the safety, tolerability, PK and efficacy of ZN-A-1041 as a monotherapy or in combination in patients with HER2-positive advanced solid tumors with or without brain metastases. The study will consist of three phases: Phase 1a (dose escalation with ZN-A-1041 monotherapy), Phase 1b (dose escalation with ZN-A-1041 combination therapy) and Phase 1c (dose expansion with ZN-A-1041 combination therapy).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/29/2024
Locations: Duke Cancer Institute, Durham, North Carolina
Conditions: Advanced Solid Tumors, HER2-positive Breast Cancer
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Genomics in Michigan to AdJust Outcomes in Prostate canceR (G-MAJOR) for Men With Newly Diagnosed Favorable Risk Prostate Cancer
NCT04396808
Recruiting
This study seeks to determine the clinical impact of Gene Expression Classifier (GEC) testing in prostate cancer care while also developing a pragmatic approach for improved GEC clinical use and future study.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/29/2024
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Prostate Cancer
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CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) Study
NCT06096675
Recruiting
Exercise training in patients with heart failure and preserved ejection fraction (HFpEF) has been associated with an improvement in cardiorespiratory fitness and quality of life.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2024
Locations: Sanger Heart and Vascular Institute, Charlotte, North Carolina
Conditions: Cardiac Amyloidosis
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Early Patient Removal of Urinary Catheters After Urogynecologic Surgery
NCT06344884
Recruiting
Management of postoperative urinary retention often requires the use of indwelling catheters. In a previous study, the investigators determined that patient removal of catheters at home is non-inferior to standard office removal on postoperative day three or four (POD3-4). The purpose of this study is to determine whether patient removal of catheters at home on postoperative day one (POD1) is noninferior to removal on POD 3-4.
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
08/27/2024
Locations: UNC Health Rex, Raleigh, North Carolina
Conditions: Urinary Retention Postoperative, Postoperative Urinary Tract Infection, Catheter Site Pain
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A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer
NCT06067841
Recruiting
The purpose of this study is to assess the safety, tolerability, and preliminary efficacy of BMS-986460 in men with Metastatic Castration-resistant Prostate Cancer.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/27/2024
Locations: Duke Cancer Institute, Durham, North Carolina
Conditions: Metastatic Castration-resistant Prostate Cancer
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An Adaptive Prenatal Intervention to Increase Childhood Vaccinations
NCT05795855
Recruiting
This study will test whether proactively connecting expectant parents with factual vaccination information during pregnancy can build confidence in vaccinations and lead to timely vaccinations during pregnancy and once their child is born.
Gender:
FEMALE
Ages:
All
Trial Updated:
08/27/2024
Locations: Duke Health System, Durham, North Carolina
Conditions: Vaccination Refusal
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64Cu-SAR-BBN and 67CU SAR-BBN for Identification and Treatment of Gastrin Releasing Peptide Receptor (GRPR)-Expressing Metastatic Castrate Resistant Prostate Cancer in Patients Who Are Ineligible for Therapy With 177Lu-PSMA-617 (COMBAT)
NCT05633160
Recruiting
The aim for this study is to determine the safety and efficacy of 67Cu-SAR-BBN in participants with Gastrin Releasing Peptide Receptor (GRPR)-expressing metastatic castrate resistant prostate cancer in patients who are ineligible for therapy with 177Lu-PSMA-617.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/27/2024
Locations: Duke University, Durham, North Carolina
Conditions: Prostatic Neoplasms, Castration-Resistant
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A Feasibility Study Utilizing Immune Recall to Increase Response to Checkpoint Therapy
NCT05077137
Recruiting
The purpose of this study is to determine the safety and feasibility of administering the Tetanus Diptheria Vaccine (Td) or Polio Boost Immunization (IPOL) to patients with metastatic melanoma who are receiving immune checkpoint inhibitor (IO) therapy per standard of care. Subjects will have the vaccine at cycle 4 of IO therapy and will have research blood and tissue samples collected prior to starting IO therapy, at cycle 4 prior to vaccine administration, and at 12-17 days post vaccine.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/27/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Melanoma
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The APS Phenotyping Study
NCT06521502
Recruiting
The goal of the observational APS phenotyping study is to better understand risk factors, potential biomarkers, length and severity of illness, and recovery for adults with ARDS, pneumonia, and/ or sepsis. This study will also generate a biobank of specimens collected from these patients that will be available to investigators for future studies of ARDS, sepsis, and/or pneumonia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: Duke University, Durham, North Carolina
Conditions: ARDS, Sepsis, Pneumonia
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Postural Control During Concurrent Cognitive Tasks During Optic Flow Stimulation
NCT05117463
Recruiting
The purpose of this study is to investigate brain activity during current visual and auditory tasks for balance control. The participants will perform cognitive, gait, and balance measures before the data collection to exclude people with neurological disorders. The participants will wear VR headset which provides visual tasks. The participants will need to maintain balance while performing concurrent visual and auditory tasks. The brain activities, reaction time, and eye-tracking data will be c... Read More
Gender:
ALL
Ages:
Between 25 years and 85 years
Trial Updated:
08/26/2024
Locations: East Carolina University, Greenville, North Carolina
Conditions: Aging, Postural Balance
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