North Carolina is currently home to 2618 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Single-incision Versus Retropubic Mid-Urethral Sling (Solyx) for SUI During Minimally Invasive Sacrocolpopexy
NCT04586166
Recruiting
SASS (Single-incision Versus Retropubic Mid-Urethral Sling (Solyx) for SUI During Minimally Invasive Sacrocolpopexy) will be a multicenter, prospective, randomized, single-blind non-inferiority trial.
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
05/28/2024
Locations: Wake Forest Baptist Medical Center, Winston-Salem, North Carolina
Conditions: Stress Urinary Incontinence, Pelvic Floor Disorders
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Hydrus® Microstent New Enrollment Post-Approval Study
NCT04553523
Recruiting
The purpose of this post-approval study is to evaluate the rate of Hydrus Microstent malposition and associated clinical sequelae occurring within 24 months post-operation. Qualified subjects will undergo uncomplicated cataract surgery with placement of a monofocal intraocular lens (IOL), followed by implantation of the Hydrus Microstent.
Gender:
ALL
Ages:
45 years and above
Trial Updated:
05/28/2024
Locations: Carolina Eye Associates PA, Southern Pines, North Carolina
Conditions: Primary Open Angle Glaucoma
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PCSK9 Inhibitor and PD-1 Inhibitor in Patients With Metastatic, Refractory To Prior Anti PD-1 Non-small Cell Lung
NCT05553834
Recruiting
PCSK9 mediates immune checkpoint blockade resistance by downregulating tumor cell surface MHC class 1 molecules. This study will evaluate if combining the anti-PCSK9 antibody alirocumab with the anti-PD-1 antibody cemiplimab can generate anti-tumor activity and clinical responses in patients with metastatic lung cancer who have progressed on first line immune checkpoint blockade therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2024
Locations: Duke University, Durham, North Carolina
Conditions: Non-small Cell Lung Cancer (NSCLC)
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Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce
NCT06239688
Recruiting
This project will compare two training models of an evidence-based online dementia care training program for direct care staff in assisted living to a waitlist control: 1) essentiALZ training and 2) essentiALZ training + Project ECHO. It will examine the extent to which each model is implemented and achieves its intended outcomes to improve staff knowledge and attitudes, change care practices, and improve the wellbeing of staff, residents, and residents' family members. Results will inform next... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Aging, Knowledge, Attitudes, Practice, Long-Term Care, Dementia
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Apathy in Parkinson Disease TMS Study
NCT06087926
Recruiting
The goal of this clinical trial is to develop non-invasive brain stimulation targets for the treatment of apathy, or motivation problems, in Parkinson Disease. The main questions the study aims to answer are: 1. Does transcranial magnetic stimulation change effort task performance in Parkinson's Disease patients? 2. Is there a link between brain signals and apathy? Participants will * complete questionnaires and assessments * perform an effort task * have their brain activity recorded (EEG)... Read More
Gender:
ALL
Ages:
Between 55 years and 80 years
Trial Updated:
05/22/2024
Locations: UNC-Chapel Hill, Cassidy Lab, Chapel Hill, North Carolina
Conditions: Parkinson Disease
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Gerofit Exercise Intervention for Older Adults With Sickle Cell Disease (SICKLE-FIT Study)
NCT05714098
Recruiting
The purpose of this study to assess the feasibility, acceptability, and safety of a personalized exercise training program adapted from Gerofit to improve physical health and quality of life for adults with SCD
Gender:
ALL
Ages:
40 years and above
Trial Updated:
05/22/2024
Locations: Duke University, Durham, North Carolina
Conditions: Sickle Cell Disease
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HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide
NCT04904588
Recruiting
This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. Post-transplant cyclophosphamide (PTCy), tacrolimus and mycophenolate mofetil (MMF) will be used for for graft versus host disease (GVHD) prophylaxis. This trial will study how well this treatment works in patients with hematologic... Read More
Gender:
ALL
Ages:
1 year and above
Trial Updated:
05/22/2024
Locations: University of North Carolina Chapel Hill, Chapel Hill, North Carolina
Conditions: Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Mixed Phenotype Acute Leukemia, Acute Leukemia, Myelodysplastic Syndromes, Chronic Myelogenous Leukemia, Chronic Lymphocytic Leukemia, Lymphoma
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Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG)
NCT04146051
Recruiting
This is a Phase IIb study to evaluate the safety and preliminary efficacy of Descartes-08 CAR T-cells in patients with Generalized Myasthenia Gravis
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2024
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Myasthenia Gravis, Generalized
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Symptom Evaluation Following Repetitive Transcranial Magnetic Stimulation
NCT06429748
Recruiting
A prospective study to evaluate symptoms following repetitive transcranial Magnetic stimulation.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
05/21/2024
Locations: Charlotte Skin and Laser, Charlotte, North Carolina
Conditions: Neurologic Symptoms
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HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry
NCT06425848
Recruiting
The purpose of the HF2 (Hemodynamic Frontiers in Heart Failure) registry is to collect relevant patient-level demographic, clinical, laboratory, and hemodynamic data from patients implanted with pulmonary artery pressure sensor at participating centers to advance scientific knowledge about ambulatory hemodynamics monitoring and HF (Heart Failure) therapies. The data collected will be used for retrospective studies, quality improvement, identifying research cohorts, and member-initiated research.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/21/2024
Locations: University of North Carolina/ Rex Hospital, Inc., Raleigh, North Carolina
Conditions: Heart Failure
Register for Updates
SenseToKnow Autism Screening Device Validation Study
NCT05874466
Recruiting
This is a pivotal, prospective, double-blind, study to evaluate the sensitivity and specificity of the SenseToKnow app for the detection of autism spectrum disorder in children 16-36 months of age.
Gender:
ALL
Ages:
Between 16 months and 36 months
Trial Updated:
05/21/2024
Locations: Duke University, Durham, North Carolina
Conditions: Autism, Autism Spectrum Disorder
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Ablation Registry (Combined Gastric Mucosal Ablation With Endoscopic Sleeve Gastroplasty for Weight Loss)
NCT06420700
Recruiting
The purpose of this study is to construct a multi-site, prospective registry to evaluate the clinical outcomes of patients who have undergone combined gastric mucosal ablation with endoscopic sleeve gastroplasty at True You Weight Loss.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/20/2024
Locations: True You Weight Loss, Cary, North Carolina
Conditions: Obesity
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