North Carolina is currently home to 2618 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer
NCT05997017
Recruiting
A Phase 2 Multi-center Open-label Trial of nab-Sirolimus in Combination with Letrozole in Advanced or Recurrent Endometrioid Endometrial Cancer
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2024
Locations: Levine Cancer Institute, Charlotte, North Carolina
Conditions: Endometrial Cancer, Endometrioid Tumor, Cancer, Tumor, Recurrent Endometrial Carcinoma, Endometrioid Endometrial Cancer
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PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes
NCT05390892
Recruiting
PRECIDENTD is a randomized, open label, pragmatic clinical trial designed to compare rates of the total number of cardiovascular, kidney, and death events among two alternative treatments for patients with type 2 diabetes (T2D) and either established atherosclerotic cardiovascular disease (ASCVD) or at high risk for ASCVD. To accomplish this objective, we will randomly assign 6,000 patients with established T2D and ASCVD or high-risk for ASCVD in a 1:1 allocation to sodium-glucose cotransporter-... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
05/20/2024
Locations: Duke University Hospital, Durham, North Carolina
Conditions: Type2Diabetes, ASCVD
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Duke COVID-19 Shared Data and Specimen Repository
NCT04368234
Recruiting
The purpose of this data repository is to provide a secure and centralized storage location and resource for the collection of essential data and medical specimens, across COVID-19 related protocols at Duke.
Gender:
ALL
Ages:
All
Trial Updated:
05/20/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: COVID-19
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Pharmacokinetics of Off Label Pediatric Medications
NCT01286519
Recruiting
The purpose of this study is to measure the level of medicines found in body fluids such as blood, urine, spinal fluid of children.
Gender:
ALL
Ages:
Between 1 day and 8 years
Trial Updated:
05/20/2024
Locations: University of North Carolina NC Children's Hospital, Chapel Hill, North Carolina
Conditions: Off Label Use of Medications in Pediatric Patients
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GBE Deficiency (GSD IV and APBD) Natural History Study
NCT02683512
Recruiting
Collection and review of clinical information related to glycogen branching enzyme (GBE) deficiency, diagnosed as Glycogen Storage Disease Type IV (GSD IV) or Adult Polyglucosan Body Disease (APBD generated during clinic visits.
Gender:
ALL
Ages:
Between 0 years and 90 years
Trial Updated:
05/17/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Glycogen Storage Disease Type IV, Adult Polyglucosan Body Disease, GSD4, GSD IV, APBD
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First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients
NCT04858269
Recruiting
The purpose of this research is to see what effects the treatment regimen chemotherapy (carboplatin and paclitaxel) plus immunotherapy (pembrolizumab), has on patients who have been diagnosed with head/neck squamous cell carcinoma and are unable to take the drug 5-fluorouracil
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2024
Locations: Wake Forest Baptist Health Sciences, Winston-Salem, North Carolina
Conditions: Head Neck Cancer, Metastatic Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma, Oropharynx Squamous Cell Carcinoma, Hypopharynx Squamous Cell Carcinoma, Larynx Squamous Cell Carcinoma
Register for Updates
Project Talk Trial: Engaging Underserved Communities in End-of-life Conversations
NCT04612738
Recruiting
Compared to the general population, individuals from underserved communities are more likely to receive low quality end-of-life care and unwanted, costly and burdensome treatments due in part to a lack of advance care planning (ACP; the process of discussing wishes for end-of-life care with loved ones/clinicians and documenting them in advance directives). This study will use existing, trusted, and respected social networks to evaluate two conversation-based tools intended to engage underserved... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2024
Locations: Greater Vision United Methodist Church, Huntersville, North Carolina
Conditions: Advance Care Planning, Advance Directives, Terminal Illness, Chronic Illness, Communication
Register for Updates
Multi-Center Study of Clinical and Inflammatory Outcomes in Intensive Cardiac Rehabilitation and Traditional Cardiac Rehabilitation Programs
NCT06424119
Recruiting
The goal of this prospective study is to evaluate whether the Intensive Cardiac Rehabilitation (ICR) program provides incremental benefits over the Traditional Cardiac Rehabilitation (TCR) program, defined by readmission costs. The study aims to confirm: * That ICR is associated with better outcomes than TCR, defined as lower readmission costs, lower incidence of major adverse cardiovascular events (MACE), and improvement in biomarkers, epigenetic markers, and inflammatory markers. * The additi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2024
Locations: Mission Health, Asheville, North Carolina
Conditions: Cardiovascular Diseases
Register for Updates
Impact of Standing Orders Optimization
NCT05742386
Recruiting
This trial will look at the impact of optimizing human papillomavirus (HPV) vaccine standing orders. The research team will work with primary care clinics. Some clinics will receive communication training. Other clinics will receive the same training and tools for increasing the use of their standing orders.
Gender:
ALL
Ages:
Between 9 years and 12 years
Trial Updated:
05/15/2024
Locations: The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Human Papilloma Virus
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Mechanisms of Disease R/R in CAR-T for Hematologic Malignancies
NCT05397132
Recruiting
The primary purpose of this IRB protocol is to perform immune profiling focusing on the measurement of Myeloid derived suppressor cells (MDSCs) over time in patients receiving Chimeric antigen receptor (CAR) T therapy and determine the correlation between immune profile and disease relapse/resistance in CAR T therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2024
Locations: Duke University, Durham, North Carolina
Conditions: Hematologic Malignancy
Register for Updates
Bempedoic Acid Pregnancy Surveillance Program
NCT05103254
Recruiting
Bempedoic acid pregnancy surveillance program
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/15/2024
Locations: Evidera, PPD business unit, Morrisville, North Carolina
Conditions: Pregnancy, Hyperlipidemias
Register for Updates
Late Onset Alzheimer's Disease
NCT05010603
Recruiting
The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to participate.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
05/15/2024
Locations: North Carolina State University, Raleigh, North Carolina
Conditions: Alzheimer Disease
Register for Updates