North Carolina is currently home to 2677 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Matrion™ Decellularized Placental Membrane in Subjects With Diabetic Foot Ulcers
NCT05087758
Recruiting
In this study, a novel placental membrane product Matrion™ (LifeNet Health, Inc., Virginia Beach, VA) will be used as a treatment for subjects with diabetic foot ulcers. Matrion is composed of placental membrane derived from donated human birth tissue containing both the innermost amniotic layer and the outermost chorionic layer, inclusive of the trophoblast layer. Matrion is minimally processed and disinfected using a proprietary decellularization technology and terminally sterilized that safel... Read More
Gender:
All
Ages:
Between 21 years and 80 years
Trial Updated:
05/19/2023
Locations: Purvis-Moyer Foot and Ankle Center, Rocky Mount, North Carolina
Conditions: Diabetic Foot, Lower Extremity Wound
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RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) Without Center Involved-Diabetic Macular Edema (CI-DME)
NCT04567550
Recruiting
RGX-314 is being developed as a novel, potential one-time gene therapy treatment for the treatment of diabetic retinopathy, a chronic and progressive complication of diabetes mellitus. Diabetic retinopathy (DR) is a sight-threatening disease characterized in the early stages by neuronal and vascular dysfunction in the retina, and later by neovascularization that leads to further deterioration of functional vision. Despite the availability of current treatments, diabetic retinopathy remains the l... Read More
Gender:
All
Ages:
Between 25 years and 89 years
Trial Updated:
05/18/2023
Locations: Duke University Eye Center, Durham, North Carolina
Conditions: Diabetic Retinopathy (DR)
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ROSE-Longitudinal Assessment With Neuroimaging
NCT05089331
Recruiting
The investigators will perform follow-up on 250 of 500 cases recruited into the ROSE study of cases with deep and lobar intracerebral hemorrhage to perform advanced neuroimaging at 12-24 months post stroke, and evaluations of motor and cognitive function at baseline, 6 months after baseline, and 12 months after baseline to determine predictors of recovery, progressive cognitive or functional impairment. The investigators propose to leverage the recruitment, DNA, RNA-seq and baseline advanced neu... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/11/2023
Locations: Duke University, Durham, North Carolina
Conditions: Intracerebral Hemorrhage
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Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque With High Stroke Risk
NCT04063709
Recruiting
Stroke is a leading cause of death and disability in the United States and around the world. The goal of this work is to develop and test a noninvasive ultrasound-based imaging technology to better identify patients at high risk of stroke so that appropriate and timely intervention may be administered to prevent it.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/09/2023
Locations: The University of North Carolina at Chapel Hill Hospitals, Chapel Hill, North Carolina
Conditions: Plaque, Atherosclerotic, Carotid Artery Plaque, Carotid Stenosis
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A Longitudinal, Observational Study of Primary Ciliary Dyskinesia in Adults
NCT05685186
Recruiting
The goal of this observational study is to characterize clinical measures and biomarkers of airway disease in adults with primary ciliary dyskinesia (PCD) and in a group of healthy volunteers (HV) to establish normative values. Lung function, mucociliary clearance, radiological findings, and clinical findings will be assessed. Furthermore, quality of life will be assessed using QOL-PCD, a disease specific questionnaire.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
04/27/2023
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Primary Ciliary Dyskinesia
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PRospective rEgistry OF Advanced Stage cancER (PREFER) Patients to Assess Prevalence of Actionable Biomarkers and Driver Mutations to Address Disparities in Precision Medicine
NCT05697198
Recruiting
The objective of this Study is to collect, process, and transfer biologic samples such as blood and/or tissue biopsies to determine the concordance of detected alterations obtained through liquid biopsy analyses compared to next generation sequencing of time-matched or archival tissue specimens from individuals with advanced solid tumors. Examples of locally advanced and metastatic tumors include stage III and IV cancers (ex. lung, breast, all gastrointestinal malignancies, all gynecologic mali... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/26/2023
Locations: Clinical Site, Huntersville, North Carolina
Conditions: Lung Cancer, Ovarian Cancer, Uterine Cancer, Colorectal Cancer, Stomach Cancer, Esophageal Cancer, Pancreatic Cancer, Melanoma, Breast Cancer, Head and Neck Cancer, Soft Tissue Sarcoma, Rhabdomyosarcoma, Prostate Cancer
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KM3D Multicenter Cancer Consortium: Predicting Patient Response Using 3D Cell Culture Models
NCT05338073
Recruiting
This study will assess the ability of the Known Medicine platform to predict the efficacy of certain cancer drug treatments and to validate that tumor organoid drug sensitivity is representative of patient treatment outcomes.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/21/2023
Locations: Duke Cancer Institute, Durham, North Carolina
Conditions: Cancer, Predictive Cancer Model, Effects of Chemotherapy
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MIT-001 for Prevention of CCRT-Induced OM in HNSCC Patients
NCT04651634
Recruiting
The proposed study in patients with previously untreated locally advanced head and neck squamous cell carcinoma (HNSCC) is designed to evaluate the efficacy and safety of three different doses of MIT-001 compared to the placebo in prevention of oral mucositis (OM) in patients with HNSCC who are undergoing concurrent chemoradiotherapy (CCRT).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/21/2023
Locations: Wake Forest Baptist Health - Comprehensive Cancer Center, Winston-Salem, North Carolina
Conditions: Oral Mucositis, Head and Neck Squamous Cell Carcinoma
Register for Updates
Comparison of Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The COMPASS Trial)
NCT05268094
Recruiting
COMPASS is a prospective multicenter randomized interventional trial. Participants with ductal-dependent pulmonary blood flow will be randomized to receive either a systemic-to-pulmonary artery shunt or ductal artery stent. Block randomization will be performed by center and by single vs. two ventricle status. Participants will be followed through the first year of life.
Gender:
All
Ages:
Between 1 day and 30 days
Trial Updated:
04/12/2023
Locations: Levine Children's Hospital, Charlotte, North Carolina
Conditions: Congenital Heart Disease in Children
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DPX-Survivac and Pembrolizumab With and Without Intermittent Low-Dose Cyclophosphamide, in Subjects With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
NCT04920617
Recruiting
This is a Phase 2b, randomized, open label study to assess the safety and efficacy of DPX-Survivac and pembrolizumab, with and without low-dose cyclophosphamide (CPA) in subjects with relapsed or refractory DLBCL.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/05/2023
Locations: Brody School of Medicine at East Carolina University, Greenville, North Carolina
Conditions: Relapsed Diffuse Large B-cell Lymphoma, Refractory Diffuse Large B-cell Lymphoma
Register for Updates
Study to Evaluate the Reliability, Validity and Safety of Subjective Mobile Refraction
NCT05049070
Recruiting
This study evaluates the reliability, validity and safety of a self administered, subjective refraction test via a mobile medical app (GoEyes) as compared to standard of care subjective manifest refraction performed by a health care provider, in subjects who have no known ocular disease or condition other than refractive error.
Gender:
All
Ages:
Between 18 years and 39 years
Trial Updated:
04/04/2023
Locations: Core, Inc Vita Eye Clinic, Shelby, North Carolina
Conditions: Refractive Errors
Register for Updates
The Hancock Jaffe Surgical Antireflux Venous Valve Endoprosthesis Study
NCT04943172
Recruiting
A prospective, non blinded, single arm, multicenter study designed to assess the safety and effectiveness of the bioprosthetic, VenoValve, which is surgically implanted into the deep venous system for treatment of patients with deep venous valvular insufficiency ( C4b-C6 patients).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2023
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Deep Venous Insufficiency (Diagnosis)
Register for Updates