North Carolina is currently home to 2644 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study
NCT04372524
Recruiting
This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults undergoing allogeneic hematopoietic stem cell transplant. By developing an early risk stratification of patients into low-, intermediate-, and high-risk for future cGvHD development (based upon their biomarker profile, before the onset of cGvHD), pre-emptive therapies aim... Read More
Gender:
ALL
Ages:
Between 0 years and 24 years
Trial Updated:
12/02/2023
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Chronic Graft-versus-Host-Disease, Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation, Blood Cancer, Non-Malignant Hematologic and Lymphocytic Disorder
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Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C Melanoma Patients
NCT03567889
Recruiting
The trial aims to evaluate the efficacy of Daromun neoadjuvant treatment followed by surgery and adjuvant therapy to improve in a statistically significant manner the recurrence-free survival (RFS) of Stage IIIB/C melanoma patients with respect to the standard of care (surgery and adjuvant therapy).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/29/2023
Locations: Duke University Medical Center - Duke Cancer Center, Durham, North Carolina
Conditions: Melanoma Stage IIIB/C
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Labor Status Monitor for Diagnosing True vs False Labor in Preterm Patients
NCT06157203
Recruiting
This is an observational study of pregnant persons in threatened labor. The study device will record electromyography signals, then the signals will be examined to determine who is in true labor and who is in threatened labor. The two goals are: * To establish the thresholds for the Contraction Synchronization Index (CSI) and the False Labor Index (FSI) to be used by the Labor Status Monitor to diagnose in-Labor or Not-in-Labor for preterm patients with threatened labor * To obtain feedback fro... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
11/27/2023
Locations: Dume University Medical Center, Durham, North Carolina
Conditions: PreTerm Labor, Threatened Preterm Labor, Preterm Birth
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Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis:
NCT05505552
Recruiting
The overall goal of this pilot randomized trial is to obtain necessary prerequisite data to conduct a randomized controlled intervention to test the effect of vitamin K supplementation on knee osteoarthritis progression and related functional decline. To address critical parameters required to design this larger RCT, we will conduct a double-blind, 2-armed, parallel-group intervention study, with a placebo run-in, in which 50 adults with mild to moderate knee OA and low baseline vitamin K status... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
11/27/2023
Locations: University of North Carolina Chapel Hill, Chapel Hill, North Carolina
Conditions: Osteo Arthritis Knee
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Health Effects of Repeated Exposure to Low Levels of Concentrated Ambient Particles in Healthy Young Volunteers
NCT05323240
Recruiting
Purpose: To determine whether 3-day consecutive exposures to levels of fine particulate matter (PM2.5) that are close to the current 24-hr national standard will cause changes in inflammatory and cardiopulmonary endpoints in healthy young individuals. Participants: 20 healthy males and females aged 18-35 years. Procedures (methods): Subjects will be randomly exposed to three consecutive days of filtered air (4 hr/day) and three consecutive days of PM2.5 (approximately 35 µg/m3; 4 hr/day) in an... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
11/27/2023
Locations: EPA Human Studies Facility, Chapel Hill, North Carolina
Conditions: Air Pollution
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Mavacamten Pregnancy Surveillance Program
NCT05939700
Recruiting
The purpose of this observational pregnancy safety study is to assess maternal, fetal, and infant outcomes after exposure to mavacamten at any time during pregnancy and/or breastfeeding.
Gender:
FEMALE
Ages:
15 years and above
Trial Updated:
11/22/2023
Locations: The Mavacamten Pregnancy Surveillance Program, PPD Inc, Wilmington, North Carolina
Conditions: Breastfeeding, Hypertrophic Cardiomyopathy, Pregnancy Related
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A Self-compassion Focused Intervention for Internalized Weight Bias and Weight Loss
NCT05987306
Recruiting
The goal of clinical trial is to test a novel weight loss approach combining a standard weight loss and internalized weight bias intervention with self-compassion exercises in overweight adults with moderate to high levels of internalized weight bias. The main question\[s\] it aims to answer are: 1) Can participants lose significant weight loss and 2) significantly reduce internalized weight bias. Participants will take part in a 12 week novel weight loss approach combining a standard weight los... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/10/2023
Locations: East Carolina University, Greenville, North Carolina
Conditions: Overweight and Obesity
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Effect of Biktarvy & Symtuza on microRNAs in HIV and Correlation With Weight Gain
NCT05463783
Recruiting
The purpose of this research study is to understand why certain HIV medication regimens (called anti-retroviral or ARV medications) cause more weight gain than others. In this research, the investigators will compare micro-RNA profiles of people who take Symtuza(darunavir(D)/cobicistat(C)/emtricitabine(F)/tenofovir alafenamide (TAF))\[D/C/F/TAF\] with those who take Biktarvy(bictegravir(B)/emtricitabine(F)/tenofovir alafenamide (TAF))\[B/F/TAF\] and try to correlate this with the change in body... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/10/2023
Locations: Adult Specialty Care Clinic-East Carolina University, Greenville, North Carolina
Conditions: HIV Infections, Obesity
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Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.
NCT04775745
Recruiting
This is a phase I, multi-center, open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics and clinical activity of LP-168 in subjects with relapsed or refractory B-cell malignancies. LP-168 is a small molecule inhibitor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/10/2023
Locations: Duke Univerisity, Durham, North Carolina
Conditions: CLL/SLL, Waldenstrom Macroglobulinemia, Follicular Lymphoma, Diffuse Large B Cell Lymphoma, Mantle Cell Lymphoma, Marginal Zone Lymphoma, Hairy Cell Leukemia
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Discharge Readmission Analysis and Management in Sepsis (DReAMS-2)
NCT06099756
Recruiting
This is an adaptive platform. This study is being done to collect information that will help us identify trends in patients with sepsis and other health conditions being readmitted into hospitals within 30 days of being discharged. This information will be used to create a computer tool that will help predict a patient's risk of being readmitted into the hospital after being discharged. Participants will allow the study team to follow their health after they are discharged by taking their tempe... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
11/06/2023
Locations: Duke Regional Hospital, Durham, North Carolina
Conditions: Sepsis
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Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL
NCT05082519
Recruiting
This study is for older children, adolescents, and young adults with B-cell Acute Lymphoblastic Leukemia (B-ALL). Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. Chemotherapy during the first month causes large gains in body fat in most people, even those who start chemotherapy at a healthy weight. This study is being done to find out if caloric restriction achieved by a personalized nutritional menu and exercise plan during routine chemotherapy... Read More
Gender:
ALL
Ages:
Between 10 years and 25 years
Trial Updated:
10/25/2023
Locations: Levine Children's Hospital, Charlotte, North Carolina
Conditions: B-cell Acute Lymphoblastic Leukemia, Obesity
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A Study of APG-2575 in Combination With Azacitidine in Patients With Acute Myeloid Leukemia (AML)
NCT04964518
Recruiting
This is a Phase Ib/II, open-label, multi-center study evaluating the safety, tolerability, efficacy and PK of APG-2575 in combination with Azacitidine in the patients with AML/MPAL or MDS/CMML. The study consists of dose escalation (Part I) and dose expansion phase (Part II)
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
10/23/2023
Locations: Novant Health, Charlotte, North Carolina
Conditions: AML, Adult
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