North Carolina is currently home to 2641 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Extended-release Tablets in Pediatric Subjects Aged 5 to 17 Years With Active, Mild to Moderate Ulcerative Colitis
NCT04314375
Recruiting
This is a randomized, double-blind, placebo-controlled, multicenter, study to evaluate the efficacy, safety, and pharmacokinetics (PK) of budesonide extended-release tablets for the induction of remission in pediatric subjects, with active, mild to moderate ulcerative colitis (UC). Subjects will be permitted to continue taking background oral or rectal 5-aminosalicylate (5-ASA) products.
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
10/05/2023
Locations: Bausch Health Site 010, Greenville, North Carolina
Conditions: Ulcerative Colitis
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Biomarker Development for Muscular Dystrophies
NCT05019625
Recruiting
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies. The investigators are interested in finding less invasive methods that reduce the need for muscle biopsies. The purpose of this research is to learn about the possibility of detecting and measuring the activity and severity of muscular dystrophies by examining a urine sample and a blood sample, and some muscles in the arms and legs using t... Read More
Gender:
ALL
Ages:
5 years and above
Trial Updated:
10/04/2023
Locations: Wake Forest University, Winston-Salem, North Carolina
Conditions: Myotonic Dystrophy, Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, Facioscapulohumeral Muscular Dystrophy
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Estrogen Variability and Irritability During the Menopause Transition
NCT05388656
Recruiting
Women in the menopause transition (perimenopause) experience substantial day-to-day variability in estradiol and have a 2-4-fold increase in major depression risk. About 40% of perimenopausal women are susceptible to the emergence of affective symptoms tied to changes in estradiol. Among the perimenopausal women with affective impairment, most report irritability, not "depression," is their primary source of impairment and distress. The purpose of this research is to determine the neurophysiolog... Read More
Gender:
FEMALE
Ages:
Between 45 years and 59 years
Trial Updated:
10/02/2023
Locations: Carolina Crossing B, Suite 1, Chapel Hill, North Carolina
Conditions: Menopause, Irritable Mood
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Hearing Screener Study
NCT05848804
Recruiting
The objective is to compare the Linus Health Hearing Screener (LHHS) to established hearing screening methods performed by a hearing specialist. We will perform an in-office speech hearing test and compare the thresholds with those measured from the iPad at a distance of 1ft with a sound pressure level (SPL) (dBA) meter
Gender:
ALL
Ages:
55 years and above
Trial Updated:
09/27/2023
Locations: Crossover Mangement, Wake Forest, North Carolina
Conditions: Hearing Screener
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Advancing Vaccine Equity Through Understanding Vaccine Hesitancy, Barriers, and Trust
NCT05537714
Recruiting
In the proposed study, the investigators will conduct qualitative interviews and focus groups with Black, Hispanic, and medically underserved communities, living in the rural south and will provide a quantitative survey (mixed methods) to identify reasons for vaccine hesitancy, including any structural barriers experienced by this population. The investigators will assess what vaccination messaging was received by trusted individuals and how this messaging may have impacted vaccination behavior.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2023
Locations: East Carolina University, Greenville, North Carolina
Conditions: Vaccine Hesitancy, Structural Barriers, Vaccine Trust
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Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction
NCT06061549
Recruiting
The goal of this clinical trial is to test an experimental gene therapy in participants with heart failure with preserved ejection fraction, also known as diastolic heart failure. The main questions it aims to answer are: * safety and tolerability of the gene therapy; and * whether the gene therapy helps the heart ventricles relax during filling. Participants will undergo a one-time infusion of the gene therapy in the cardiac catheterization laboratory and then be followed for safety and effect... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
09/23/2023
Locations: Duke University, Durham, North Carolina
Conditions: Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction
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The Efficacy and Safety of Bonjesta® for Nausea and Vomiting of Pregnancy in Pregnant Adolescents
NCT05289557
Recruiting
The primary objective of this study is to compare the efficacy of Bonjesta for the treatment of nausea and vomiting of pregnancy (NVP) in pregnant adolescents aged 12 to 17 years with placebo. The secondary objective of this study is to compare the safety of Bonjesta in pregnant adolescents aged 12 to 17 years with placebo.
Gender:
FEMALE
Ages:
Between 12 years and 17 years
Trial Updated:
09/08/2023
Locations: Unified Women's Clinical Research, Winston-Salem, North Carolina
Conditions: Morning Sickness
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Use of AC5® Advanced Wound System in the Treatment of Diabetic Foot Ulcers
NCT06028386
Recruiting
The purpose of this clinical evaluation is to collect and compare outcomes data from patients with UT 1A diabetic foot ulcers treated with 510K FDA cleared, commercially available self-assembling peptide, AC5®Advanced Wound System, as compared to an advanced standard of care. Patient outcomes will be compared at the end of the study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/07/2023
Locations: Dr. Christopher Gauland, Greenville, North Carolina
Conditions: Non-healing Wound, Diabetic Foot Ulcer
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Study of 3D Scanning for Adolescent Scoliosis
NCT06035952
Recruiting
The investigators aim to validate three-dimensional topographical scanning technology as a tool for evaluation of scoliosis. Through the incorporation of 3D topographical technology in the measurement of deformity, the investigators hope to validate a novel approach to quantify deformity progression and provide an accessible alternative to traditional radiographic workup.
Gender:
ALL
Ages:
Between 10 years and 18 years
Trial Updated:
09/06/2023
Locations: Duke University, Durham, North Carolina
Conditions: Scoliosis
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A Phase 3 Study to Investigate the Efficacy and Safety of SHR0302 With Moderately to Severely Active Ulcerative Colitis
NCT05181137
Recruiting
This is a randomized, double-blind, placebo-controlled, multicenter Phase 3 study that will enroll approximately 368 subjects aged 18 to 75 years old with Moderately to Severely Active Ulcerative Colitis.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
09/01/2023
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Ulcerative Colitis
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AltaValve Early Feasibility Study Protocol
NCT03997305
Recruiting
Prospective, single-arm, multicenter study to evaluate the safety and performance of the AltaValve for the treatment of moderate to severe or severe mitral valve regurgitation in subjects who are considered high risk for mortality and morbidity from conventional open-heart surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/31/2023
Locations: Atrium Health, Charlotte, North Carolina
Conditions: Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
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A Study of Voruciclib Alone or in Combination With Venetoclax in Subjects With B-Cell Malignancies or AML
NCT03547115
Recruiting
This is a Phase 1, open-label, dose escalation study to determine the safety and preliminary efficacy of voruciclib monotherapy in subjects with relapsed/refractory B cell malignancies or AML after failure of standard therapies or voruciclib in combination with venetoclax in subjects with relapsed or refractory AML
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/03/2023
Locations: Duke University, Durham, North Carolina
Conditions: Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), Small Lymphocytic Lymphoma (SLL), Chronic Lymphocytic Leukemia (CLL), Diffuse Large B-cell Lymphoma (DLBCL), Acute Myeloid Leukemia (AML)
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