North Carolina is currently home to 2641 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
NCT04301843
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma.
Gender:
ALL
Ages:
31 years and below
Trial Updated:
07/21/2025
Locations: Levine Children's Hospital, Charlotte, North Carolina
Conditions: Neuroblastoma
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Transformative Research in Diabetic Nephropathy
NCT02986984
Recruiting
This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that characterize those patients have a rapid decline in kidney function (\> 5 mL/min/1.73m2/year) from those with lesser degrees of kidney function change over the period of... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
07/21/2025
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Diabetic Nephropathies, Diabetic Glomerulosclerosis
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A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma
NCT06007690
Recruiting
The primary objective is to determine the safety and efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melanoma (CM).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/20/2025
Locations: Duke Eye Center, Durham, North Carolina
Conditions: Choroidal Melanoma, Indeterminate Lesions, Uveal Melanoma, Ocular Melanoma
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BREAST Choice Decision Tool R21
NCT06817226
Recruiting
Breast reconstruction is a critical component of breast cancer treatment because it restores quality of life and body image after mastectomy. However, Spanish-speaking Latina women are significantly less likely to undergo reconstruction (13.5% vs. 41% for non-Latina White or highly acculturated Latina), meet with a reconstructive surgeon (18.1% vs. 72.6% for non-Latina White), or receive adequate information. Spanish-speaking Latina breast cancer survivors who do not have reconstruction experien... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/19/2025
Locations: The University of North Carolina, Chapel Hill, North Carolina
Conditions: Breast Cancer
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Resources for Optimizing Outcomes in Toddlers on the Spectrum
NCT07086781
Recruiting
The goal of this clinical trial is to assess whether telehealth-based Family Navigation (FN) expedites enrollment (e.g., reduces time in days) in community-based autism intervention for toddlers under the age of 4 living in Rural NC after their initial diagnosis of autism. The main questions it aims to answer are: Does Family Navigation decrease the time to initiation of intervention for rural toddlers with autism? Does Family Navigation improve developmental outcomes at 18 months post-diagno... Read More
Gender:
ALL
Ages:
Between 1 year and 99 years
Trial Updated:
07/18/2025
Locations: Carolina Institute for Developmental Disabilities, Carrboro, North Carolina
Conditions: Autism Spectrum Disorder
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Pancoronavirus Vaccine Study in Healthy Adults
NCT06950177
Recruiting
Coronaviruses (CoVs) have caused the severe acute respiratory syndrome (SARS) outbreak, the Middle East Respiratory Syndrome (MERS) outbreak, and now the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Although there are several approved or authorized vaccines for SARS-CoV-2, there are currently no vaccines approved to prevent diseases caused by multiple different coronaviruses. Two countermeasures with promise for controlling coronavirus outbreaks are recombinant neutrali... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/18/2025
Locations: Duke University Health System, Durham, North Carolina
Conditions: COVID-19 Respiratory Infection, SARS CoV 2 Infection, COVID-19 Vaccine
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MagDI U.S. Registry
NCT06928545
Recruiting
Assess the incidence and severity of internal hernia and bowel obstruction at one year in a U.S. population following use of the MagDI System to create side-to-side duodeno-ileal anastomoses.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
07/18/2025
Locations: Bariatric Specialists of the Carolinas, Cary, North Carolina
Conditions: Anastomosis, Surgical, Internal Hernia, Bowel Obstruction
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Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction
NCT06927973
Recruiting
The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart (heart failure with preserved ejection fraction or HFpEF).
Gender:
ALL
Ages:
50 years and above
Trial Updated:
07/18/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Chest Pain, Shortness of Breath
Register for Updates
A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma
NCT06876662
Recruiting
Study J2N-MC-JZ01 (JZ01) is an individual-study appendix (ISA) under master protocol J2N-MC-JZNY, and represents participants from the completed originator study, clinical study LOXO-BTK-18001/J2N-OX-JZNA. Participants in the originator study will have the opportunity to continue their assigned study intervention or continue their follow-up visits by transitioning to this study. This study will evaluate the long-term safety and efficacy of pirtobrutinib.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma
Register for Updates
Mirikizumab in the Treatment of Chronic Inflammatory Conditions of the Pouch
NCT06864403
Recruiting
The goal of this clinical trial is to learn if mirikizumab works to treat pouch disorders in adults. The main questions it aims to answer are: Does mirikizumab reduce symptoms of pouch disorders Participants will: Take mirikizumab every 4 weeks for one year Visit the clinic once every month for two months and at the end of the study Keep a diary of their symptoms
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/18/2025
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Pouchitis, Pouches, Ileoanal, Pouch, Ileal
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Innovative Automated Insulin Delivery System for Type 2 Diabetes
NCT06853990
Recruiting
The goal of this clinical trial is to learn if the twiist insulin delivery system works to treat adults with insulin-treated type 2 diabetes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2025
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Type 2 Diabetes, Insulin Treated Type 2 Diabetes Mellitus
Register for Updates
Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S02)
NCT06611553
Recruiting
This clinical trial evaluates the use of self-collected vaginal samples for human papillomavirus (HPV) testing in patients referred for a colposcopy and/or cervical excisional procedures to improve cervical cancer prevention. HPV is a common virus which usually causes infections that last only a few months, but sometimes can last longer. It is known to cause a variety of cancers including cancer of the cervix. Even though there are ways to detect cervical cancer early, many individuals do not un... Read More
Gender:
FEMALE
Ages:
25 years and above
Trial Updated:
07/18/2025
Locations: UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Conditions: Cervical Carcinoma, Human Papillomavirus Infection
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