There are currently 1282 clinical trials in Cleveland, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Cleveland Clinic, Cleveland Clinic Foundation, Case Western Reserve University and University Hospitals Cleveland Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
NCT04488081
Recruiting
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients. In this phase 2 platform design, agents will be identified with a signal suggesting a big impact on reducing mortality and the need for, as well as duration, of mechanical ventilation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/15/2024
Locations: University Hospital Cleveland Medical Center, Cleveland, Ohio
Conditions: COVID-19
Register for Updates
Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational Age
NCT05345457
Recruiting
A randomized, controlled, non-placebo trial to primarily assess the effect of oral, outpatient antibiotics (i.e., azithromycin and amoxicillin) on latency (i.e., proportion of patients that deliver within 28 days from membrane rupture) following previable, prelabor rupture of membranes between 18 0/7 and 22 6/7 weeks gestational age.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: University Hospitals, Cleveland, Ohio +2 locations
Conditions: Pregnancy Preterm, Pregnancy Prom, PROM, Preterm (Pregnancy), PROM (Pregnancy), Premat Rupture Membranes Preterm Unspec to Length of Time Between Rupture/Labor, Premature Birth
Register for Updates
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT06322693
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: GSK Investigational Site, Cleveland, Ohio
Conditions: Neoplasms
Register for Updates
Project 2 Airway Potential Hydrogen (pH) in Asthma
NCT03617718
Recruiting
This study is testing a non invasive way to measure airway pH in individuals with Asthma and Cystic Fibrosis using a new inhaled drug. The airway pH will help health care providers in creating tailored treatment plans for individuals suffering from these specific conditions.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
03/13/2024
Locations: University Hospitals Cleveland Medical Center - Asthma Research Center, Cleveland, Ohio
Conditions: Cystic Fibrosis, Asthma, Severe Persistent Asthma, Healthy
Register for Updates
Evaluation of the PrevisEA Device for Predicting Gastrointestinal Impairment
NCT04880473
Recruiting
PrevisEA is a noninvasive, disposable device that uses audio spectral analysis of sounds produced by the gastrointestinal tract to predict gastrointestinal impairment (GII). GII is most commonly associated with postoperative ileus (POI), but could be the result of other causes, such as early postoperative bowel obstruction. GII is defined as failure of successful early oral re-feeding in a subject undergoing major abdominal surgery. For subjects who are allowed to resume a diet during the first... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/11/2024
Locations: The Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Gastrointestinal Complication
Register for Updates
A Phase 1 Study of NM6603 in Advanced Solid Tumors
NCT06046066
Recruiting
This study is to assess the MTD and RP2D of NM6603 in adult patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2024
Locations: Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio
Conditions: Cancers
Register for Updates
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
NCT04536103
Recruiting
Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health. Towards this goal, extensive efforts are ongoing to develop quantitative MRI for cartilage matrix analysis. MR T1ρ and T2 relaxation times have shown to be promising imaging biomarkers for early cartilage degeneration and prediction of disease progression. However, many c... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
03/06/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Bone Diseases, Infectious, Musculoskeletal Diseases, Joint Diseases, Osteoarthritis, ACL Tear, Cartilage Degeneration
Register for Updates
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
NCT05442567
Recruiting
The study is an extension of two parent studies (MLN0002-3024 \[NCT04779307\] and MLN0002-3025 \[NCT04779320\]). Participants must have participated in one of the previous studies. The purpose of this study is to collect the long-term safety of vedolizumab in children with UC or CD.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/05/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Ulcerative Colitis, Crohn's Disease
Register for Updates
CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting
NCT05002543
Recruiting
MANTRA is a prospective, multiple-arm, multi-center, global, post-market clinical follow-up study. The main objective is to monitor ongoing safety and performance of the CORCYM devices and accessories used for aortic, mitral and tricuspid valvular diseases in a real-world setting. Corcym S.r.l., is a medical device manufacturer with a broad product portfolio for cardiac surgeons, offering solutions for the treatment of aortic, mitral and tricuspid valve disease. The MANTRA Master Plan (Master... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/05/2024
Locations: University Hospitals Cleveland, Cleveland, Ohio +1 locations
Conditions: Cardiac Valve Disease
Register for Updates
Kaneka Endovascular Embolization and Protection
NCT05563051
Recruiting
Prospective, multi-center, non-randomized registry / study, up to 164 patients enrolled and followed at 180 days +/- 45 days and again at 365 days +/- 90 days post procedure
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/04/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Aneurysm Cerebral
Register for Updates
Alvimopan as a Rescue Treatment of Postoperative Ileus
NCT04405037
Recruiting
This study aims to evaluate the cost effectiveness of Alvimopan as rescue therapy in patients undergoing colorectal or small bowel resection who develop POI, and its safety and effectiveness in reducing LOS and POI duration. This will be a prospective randomized control trial with a total of 58 patients, 29 in each group. Patients who undergo laparoscopic or open colorectal resection, small bowel resection, or ileostomy reversal with small bowel resection that subsequently develop postoperative... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Ileus, Gastrointestinal Dysfunction
Register for Updates
Effect of Limb Length Ratio on Roux-en-Y Gastric Bypass Outcomes (CLIMB II Study)
NCT06293703
Recruiting
The investigators propose a randomized controlled trial comparing BP and roux limb lengths measuring 30 and 15% respectively of patient's total small bowel length versus current standard practice using fixed lengths. The findings would provide further insight into feasibility of standardizing RYGB limb lengths and optimizing resultant weight loss and metabolic effects. The investigators hypothesize RYGB with ratio-adjusted limb lengths (aRYGB) will result in higher total weight loss and resoluti... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/27/2024
Locations: Cleveland clinic, Cleveland, Ohio
Conditions: Morbid Obesity
Register for Updates