There are currently 1276 clinical trials in Cleveland, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Cleveland Clinic, Cleveland Clinic Foundation, Case Western Reserve University and University Hospitals Cleveland Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Postpartum Vaginal Estrogen for Breastfeeding Patients
NCT05457972
Recruiting
Sexual dysfunction is very common in the postpartum period and is more common in people who breastfeed or pump. This research study was designed to help determine whether postpartum patients who use vaginal estrogen cream while breastfeeding have improved sexual function compared to postpartum patients who do not.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
03/11/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Breastfeeding, Postpartum Sexual Dysfunction, Vaginal Atrophy
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A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.
NCT05984277
Recruiting
The purpose of eVOLVE-Lung02 is to test the effectiveness (efficacy) and measure the safety of volrustomig in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy as 1L treatment in participants with mNSCLC in PD-L1 \< 50%.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: Research Site, Cleveland, Ohio
Conditions: Metastatic Non-small Cell Lung Cancer
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Quantra Point-of-Care Hemostasis Monitoring
NCT06328647
Recruiting
The investigators will test the hypothesis that utilization of a blood and blood component transfusion algorithm guided by the POC Quantra QPlus System in patients undergoing complex cardiac surgery will reduce RBC, plasma, cryoprecipitate, and platelet transfusion during surgery and the first 12 postoperative hours, compared to standard of care (central laboratory transfusion monitoring at the primary anesthesia provider's discretion).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Bleeding, Hemostatic Disorder
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Gastroschisis Outcomes of Delivery (GOOD) Study
NCT02774746
Recruiting
The objective of this study is to investigate the hypothesis that delivery at 35 0/7- 35 6/7 weeks in stable patients with gastroschisis is superior to observation and expectant management with a goal of delivery at 38 0/7 - 38 6/7 weeks. To test this hypothesis, we will complete a randomized, prospective, multi-institutional trial across NAFTNet-affiliated institutions. Patients may be enrolled in the study any time prior to 33 weeks, but will be randomized at 33 weeks to delivery at 35 weeks o... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Gastroschisis
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Development of Predictive Psoriasis Response Endotypes Using Single Cell Transcriptomics
NCT05270733
Recruiting
The investigators propose to improve the possibility of reaching skin resolution by identifying certain markers or gene patterns that may predict patient response to certain psoriasis drugs ahead of time, thus eliminating or reducing the trial-and-error approach often employed. The ability to rule out (or in) specific therapeutics based on predictive efficacy would lead to a more personalized approach for psoriasis treatment. To do this, the investigators will be asking participants to try two... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
03/11/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Psoriasis
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Pilot/Pivotal Study of DBS+Rehab After Stroke
NCT05701280
Recruiting
The RESTORE Stroke Study will evaluate the safety and effectiveness of DBS+Rehab for treating arm weakness and reduced function after a stroke.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/11/2025
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Stroke, Upper Extremity Paresis
Register for Updates
Social Interventions for Support During Treatment for Endometrial Cancer and Recurrence
NCT04930159
Recruiting
The SISTER study is a randomized trial, looking at various modalities of social support for Black patients undergoing treatment for endometrial cancer. There are three study arms: group support, 1:1 peer support, and enhanced usual care. The primary outcome is treatment completion, and the secondary outcome is social isolation.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Endometrial Cancer
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Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial
NCT04684719
Recruiting
Open label, multi-center, pre-hospital randomized trial utilizing 10 level-1 trauma centers designed to determine the efficacy and safety of low titer whole blood resuscitation as compared to standard of care resuscitation in patients at risk of hemorrhagic shock and to appropriately characterize the hemostatic competency of whole blood relative to its age.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
03/10/2025
Locations: Metrohealth Systems, Cleveland, Ohio
Conditions: Hemorrhagic Shock, Traumatic Injury
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Phase 2 Study to Assess the Safety, PK, and PD in SBS-IF Subjects
NCT04775706
Recruiting
This is a randomized, double-blind, placebo-controlled, proof-of-concept (PoC), Phase 2 study to assess the safety, PK, and PD of SC administration of HM15912(sonefpeglutide) in adult subjects with SBS-associated intestinal failure (SBS-IF).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/10/2025
Locations: The Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Short Bowel Syndrome
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Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors
NCT06578624
Recruiting
The objective of this study is to assess the safety, efficacy, and pharmacokinetics of SA53-OS in adult participants with refractory solid tumors. The study is comprised of 2 parts: Part 1 called dose escalation, and Part 2a called dose expansion. This study starts with Part 1 where participants who are diagnosed with advanced or metastatic solid tumor cancers receive different doses of SA53-OS (starting with the lowest dose) to find the maximum tolerated dose (MTD) of SA53-OS. Once the MTD of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/10/2025
Locations: Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio
Conditions: Solid Tumor
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Human Skin and Gut Mycobiome and Bacteriome Comprehensive Registry
NCT05196061
Recruiting
Bacterial and fungal microbiota will be different between individual body sites; however, particular microbiome profiles both whole-body and site-specific will be unique to volunteers with a given parameter such as medical diagnosis, diet, medications taken, geographical area; etc.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/10/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Healthy Volunteers
Register for Updates
Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects with Leiomyosarcoma (ARGSARC)
NCT05712694
Recruiting
To compare the efficacy and safety in subjects with advanced or metastatic LMS previously treated with an anthracycline.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/10/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio +1 locations
Conditions: Soft Tissue Sarcoma
Register for Updates