There are currently 1276 clinical trials in Cleveland, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Cleveland Clinic, Cleveland Clinic Foundation, Case Western Reserve University and University Hospitals Cleveland Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
The Cancer of the Pancreas Screening-5 CAPS5)Study
NCT02000089
Recruiting
Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/10/2025
Locations: Case Comprehensive Cancer Center, Case Western Medical Reserve, Cleveland, Ohio
Conditions: Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation, Germline Mutation Carrier, Lynch Syndrome
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Antigen Specific Adoptive T Cell Therapy for Adenovirus Infection After Hematopoietic Stem Cell Transplantation
NCT03378102
Recruiting
The purpose of this study is to determine if it is possible to treat an infection with a cell-based immunotherapy (therapy that uses the patient's own immune system to treat the infection). This treatment is called adoptive T cell therapy. Another purpose is to learn about the side effects and toxicities of adoptive T cell therapy. Adoptive T cell therapy is an investigational (experimental) therapy that works by using the blood of a donor that has immunity against the virus. The donor cells ar... Read More
Gender:
ALL
Ages:
3 months and above
Trial Updated:
03/10/2025
Locations: University Hospitals, Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation
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hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM)
NCT05052957
Recruiting
This phase II trial studies the effect of P140K MGMT hematopoietic stem cells, O6-benzylguanine, temozolomide, and carmustine in treating participants with supratentorial glioblastoma or gliosarcoma who have recently had surgery to remove most or all of the brain tumor (resected). Chemotherapy drugs, such as 6-benzylguanine, temozolomide, and carmustine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing. Placing P140K MGMT, a ge... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/10/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Glioblastoma Multiforme, Glioblastoma Multiforme, Adult, Supratentorial Glioblastoma, Supratentorial Gliosarcoma
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Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial
NCT04684719
Recruiting
Open label, multi-center, pre-hospital randomized trial utilizing 10 level-1 trauma centers designed to determine the efficacy and safety of low titer whole blood resuscitation as compared to standard of care resuscitation in patients at risk of hemorrhagic shock and to appropriately characterize the hemostatic competency of whole blood relative to its age.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
03/10/2025
Locations: Metrohealth Systems, Cleveland, Ohio
Conditions: Hemorrhagic Shock, Traumatic Injury
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Phase 2 Study to Assess the Safety, PK, and PD in SBS-IF Subjects
NCT04775706
Recruiting
This is a randomized, double-blind, placebo-controlled, proof-of-concept (PoC), Phase 2 study to assess the safety, PK, and PD of SC administration of HM15912(sonefpeglutide) in adult subjects with SBS-associated intestinal failure (SBS-IF).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/10/2025
Locations: The Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Short Bowel Syndrome
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Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors
NCT06578624
Recruiting
The objective of this study is to assess the safety, efficacy, and pharmacokinetics of SA53-OS in adult participants with refractory solid tumors. The study is comprised of 2 parts: Part 1 called dose escalation, and Part 2a called dose expansion. This study starts with Part 1 where participants who are diagnosed with advanced or metastatic solid tumor cancers receive different doses of SA53-OS (starting with the lowest dose) to find the maximum tolerated dose (MTD) of SA53-OS. Once the MTD of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/10/2025
Locations: Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio
Conditions: Solid Tumor
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Human Skin and Gut Mycobiome and Bacteriome Comprehensive Registry
NCT05196061
Recruiting
Bacterial and fungal microbiota will be different between individual body sites; however, particular microbiome profiles both whole-body and site-specific will be unique to volunteers with a given parameter such as medical diagnosis, diet, medications taken, geographical area; etc.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/10/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Healthy Volunteers
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A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood Epilepsy
NCT04015141
Recruiting
The purpose of the study is to evaluate the efficacy of perampanel as measured by the 50 percent (%) responder rate during the maintenance period of the core study for seizure frequency in participants with pediatric epileptic syndrome (Cohort 1) and partial-onset seizures (POS) (Cohort 2).
Gender:
ALL
Ages:
Between 1 month and 18 years
Trial Updated:
03/09/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Pediatric Epileptic Syndrome, Partial-onset Seizures
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Pre-operative Polyethylene Glycol 3350 for Minimally Invasive Urogynecologic Surgery
NCT06159777
Recruiting
The goal of this clinical trial is to test the use of a laxative before surgery in women having surgery to fix pelvic prolapse that do not have constipation. The main question it aims to answer is: Does use of a laxative before surgery lessen the discomfort of bowel movements after surgery? Participants will be asked to complete questionnaires before and after surgery. Researchers will compare using the laxative before and after surgery versus only after surgery to see if there is less discomfo... Read More
Gender:
FEMALE
Ages:
Between 18 years and 89 years
Trial Updated:
03/07/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Constipation, Surgical Procedure, Unspecified, Prolapse; Female
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Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation Strategy Trial
NCT05822583
Recruiting
COVID-19 can trigger a dysregulated immune response, and previous studies have shown that immune modulation can improve outcomes in hospitalized patients. This trial is designed to determine whether intensification of immune modulation early in the course of the disease (while patients are on low flow oxygen) with abatacept (active arm) combined with standard of care (SOC) improves recovery as compared with placebo + SOC (placebo arm). For both groups, intensification of immunomodulation will be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: Cleveland Clinic Foundation (Site 207-001), Cleveland, Ohio
Conditions: COVID-19
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A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors
NCT04857372
Recruiting
The purpose of this study is to characterize the safety and tolerability of IAG933 in patients with mesothelioma, NF2/LATS1/LATS2 mutated tumors and tumors with functional YAP/TAZ fusions and to identify the maximum tolerated dose and/or recommended dose.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
03/07/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Mesothelioma
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Study to Assess Safety and Efficacy of Vactosertib in Adolescents and Adults with Recurrent, Refractory or Progressive Osteosarcoma
NCT05588648
Recruiting
MP-VAC-209 is a Phase I/II, open label, single arm, multi-center study to assess safety, tolerability, and antitumor activity of vactosertib as a single agent in adolescents and adults with recurrent, refractory, or progressive osteosarcoma. Vactosertib is given orally, twice a day, to people 12 years of age and older who meet the criteria for study enrollment.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
03/07/2025
Locations: UH Rainbow Babies & Children's Hospital, Cleveland, Ohio
Conditions: Osteosarcoma
Register for Updates