Pennsylvania is currently home to 3313 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)
NCT04956640
Recruiting
The purpose of this study is to find out whether the study drug, LY3537982, is safe and effective in cancer patients who have a specific genetic mutation (KRAS G12C). Patients must have already received or were not able to tolerate the standard of care, except for specific groups who have not had cancer treatment. The study will last up to approximately 4 years.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Carcinoma, Non-Small-Cell Lung, Endometrial Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Biliary Tract Neoplasms, Colorectal Neoplasms
Register for Updates
IV Gallium Study for Patients with Cystic Fibrosis Who Have NTM (ABATE Study)
NCT04294043
Recruiting
The purpose of this study is to assess the safety and tolerability of two 5-day infusion cycles of IV gallium in adult patients with CF who are infected with NTM. Funding Source - FDA Office of Orphan Products Development (OOPD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Nontuberculous Mycobacterium Infection
Register for Updates
Testicular Tissue Cryopreservation for Fertility Preservation
NCT02972801
Recruiting
Testicular tissue cryopreservation is an experimental procedure where a young boy's testicular tissue is retrieved and frozen. This technique is reserved for young male patients who are not yet producing mature sperm, with the ultimate goal that their tissue may be used in the future to restore fertility when experimental techniques emerge from the research pipeline.
Gender:
MALE
Ages:
All
Trial Updated:
03/05/2025
Locations: Magee-Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Cancer, Autoimmune Disorders
Register for Updates
Validation of Restaurant App
NCT06868056
Recruiting
Unhealthy diets significantly contribute to preventable chronic diseases among older adults. To advance the investigator's understanding of policies needed to support healthy diets, the objectives are: 1) to develop and validate an online fast food restaurant ordering application; and 2) to conduct a feasibility study for a larger randomized, controlled trial that will test healthy food policies in restaurant settings.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Chronic Disease
Register for Updates
Communication Strategies to Increase HPV Vaccination Intention
NCT06784960
Recruiting
This research aims to identify communication strategies to improve the uptake of vaccines using an experimental design, focusing on the Human Papillomavirus (HPV) vaccine, which is highly effective in preventing HPV-related cancers. However, low HPV vaccination rates among adults remain a significant public health challenge. Although randomized controlled trials (RCTs) have demonstrated that interventions can increase vaccine uptake in children, few RCTs have been conducted on adults. To address... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
03/04/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Papilloma Viral Infection, Vaccine Hesitancy, Communication
Register for Updates
Activity and Participation in Vestibular Disorders
NCT06271694
Recruiting
This study will examine whether impairments and personal factors are associated with activity and participation in people with vestibulopathy. Data collection will occur prior to starting vestibular rehabilitation and after completing vestibular rehabilitation.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/04/2025
Locations: UPMC-Rehab Institute, Pittsburgh, Pennsylvania
Conditions: Vestibular Disorder
Register for Updates
RZ358 Treatment for Congenital Hyperinsulinism
NCT06208215
Recruiting
The Phase 3 pivotal study is designed to evaluate the efficacy and safety of RZ358 for the treatment of congenital hyperinsulinism (HI) as add-on to standard-of-care (SOC) therapy compared to SOC alone over 24 weeks and to evaluate the longer-term safety and efficacy of RZ358 during a subsequent open-label extension (OLE) period.
Gender:
ALL
Ages:
Between 3 months and 45 years
Trial Updated:
03/04/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Congenital Hyperinsulinism
Register for Updates
A PIVOTAL STUDY EVALUATING SAFETY and EFFICACY of the SHIRATRONICS MIGRAINE THERAPY SYSTEM
NCT06167655
Recruiting
Prospective, multi-center, double blind, randomized, sham-controlled study to evaluate neuromodulation in patient with chronic migraine. The study hypothesis to be tested is the mean reduction in mean monthly headache days between patients in treatment versus sham.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/04/2025
Locations: Argires Marotti Neurological Associates, Lancaster, Pennsylvania
Conditions: Headache Migraine Chronic
Register for Updates
Preserving Geriatric Muscle With an Osteoporosis Medication
NCT06118905
Recruiting
Our goal is to demonstrate efficacy of the novel agent Denosumab to improve or preserve muscle health, strength, mobility and function in frail older adults.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/04/2025
Locations: St. Barnabas Woodlands, Pittsburgh, Pennsylvania
Conditions: Osteoporosis
Register for Updates
The CArdiovascular Risk Evaluation in Men With Prostate Cancer Study (CARE-PC) Pilot Feasibility Study
NCT06064149
Recruiting
The overarching goal of this trial is to develop mechanisms to improve cardiovascular care among such prostate cancer patients receiving ADT by increasing patient awareness of individualized cardiovascular risk estimates and mitigation opportunities. Patients will be given access to a web-based quality improvement tool to educate patients of cardiovascular risks in prostate cancer and to inform them of their individualized, estimated cardiovascular risk and guideline-based risk mitigation recomm... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Prostate Cancer
Register for Updates
CTNNA1 Familial Expansion Study
NCT05126290
Recruiting
The goal of the CAFÉ Study is to determine the cancer risks associated with germline CTNNA1 loss-of-function variants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Cancer Gene Mutation, Gastric Cancer, Breast Cancer
Register for Updates
Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases
NCT05029336
Recruiting
A subset of autoimmune diseases (ADs) in children and young adults are life-threatening and unresponsive to conventional treatments. In these patients, the delivery of high dose immunosuppressive therapy followed by autologous stem cell transplant (ASCT) offers a treatment strategy capable of purging the pathogenic, autoreactive immune system and an opportunity for "immune reset." This strategy has been used in adults across a myriad of indications with evidence for efficacy. This study proposes... Read More
Gender:
ALL
Ages:
Between 8 years and 25 years
Trial Updated:
03/04/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Systemic Lupus Erythematosus, Systemic Sclerosis
Register for Updates