Pennsylvania is currently home to 3313 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Nilotinib Plus Dabrafenib/Trametinib or Encorafenib/Binimetinib in Metastatic Melanoma
NCT04903119
Recruiting
This is a phase 1 dose-escalation study of nilotinib in combination with fixed-dose dabrafenib and trametinib regimen for patients with metastatic or unresectable melanoma carrying a BRAF V600 mutation and have relapsed on a BRAF/MEK inhibitor therapy. The goal is to assess the toxicity and tolerability and determine the maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D) of the combination of nilotinib with dabrafenib and trametinib or with encorafenib and binimetinib. Additionally, th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: St. Luke's University Health Network, Easton, Pennsylvania
Conditions: Metastatic Melanoma, BRAF Gene Mutation
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Shared Decision-making and Colorectal Cancer Screening
NCT04748380
Recruiting
Conduct a feasibility pilot RCT of a newly developed colorectal cancer screening (CRC) decision aid (DA) including 66 LHL adults 76-85 years recruited from community health centers. Hypotheses: Patients in the intervention group will be more likely to change their intentions to be screened with fewer patients with \<10 year LE and/or those with \>10 year LE and no risk factors intending to be screened and more with \>10 year LE and risk factors for CRC and/or those who have never been screened i... Read More
Gender:
ALL
Ages:
Between 75 years and 85 years
Trial Updated:
03/04/2025
Locations: University of Pennsylvania Health System, Philadelphia, Pennsylvania
Conditions: Colorectal Cancer
Register for Updates
Trial of Vision Therapy for Intermittent Exotropia
NCT04487249
Recruiting
The main objective of this randomized trial comparing vision therapy to observation is to determine the short-term effectiveness of vision therapy on distance intermittent exotropia control. The results will help determine whether to proceed to a full-scale, long-term randomized trial.
Gender:
ALL
Ages:
Between 8 years and 16 years
Trial Updated:
03/04/2025
Locations: Salus University, Philadelphia, Pennsylvania
Conditions: Intermittent Exotropia
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Physiological Effects of ANGPTL3 Variants in Humans
NCT04234724
Recruiting
To evaluate the role of ANGPTL3, on lipid metabolism. To explore the role of this protein on glucose metabolism.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Hypocholesterolemia
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Responsive Neurostimulation For Loss Of Control Eating
NCT03868670
Recruiting
The primary objective of this trial is to assess device function and safety, with secondary objectives including the feasibility.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
03/04/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Loss of Control Eating, Obesity, Morbid
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Neurofeedback for Treatment Resistant Depression
NCT03428828
Recruiting
The purpose of this study is to determine the clinical efficacy of real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) training to increase the amygdala's response to positive autobiographical memories in patients with depression who are considered treatment-resistant
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/04/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Treatment Resistant Depression
Register for Updates
Longitudinal Study of Neurodegenerative Disorders
NCT03333200
Recruiting
The purpose of this study is to understand the course of rare genetic disorders that affect the brain. This data is being analyzed to gain a better understanding of the progression of the rare neurodegenerative disorders and the effects of interventions.
Gender:
ALL
Ages:
All
Trial Updated:
03/04/2025
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: MLD, Krabbe Disease, ALD, MPS I, MPS II, MPS III, Vanishing White Matter Disease, GM3 Gangliosidosis, PKAN, Tay-Sachs Disease, NP Deficiency, Osteopetrosis, Alpha-Mannosidosis, Sandhoff Disease, Niemann-Pick Diseases, MPS IV, Gaucher Disease, GAN, GM1 Gangliosidoses, Morquio Disease, S-Adenosylhomocysteine Hydrolase Deficiency, Batten Disease, Pelizaeus-Merzbacher Disease, Leukodystrophy, Lysosomal Storage Diseases, Purine Nucleoside Phosphorylase Deficiency, Multiple Sulfatase Deficiency Disease
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Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts
NCT06856148
Recruiting
If science is to inform effective substance misuse prevention policy and ultimately improve public health, the field needs an effective strategy for directly supporting policymakers' use of research evidence, yet our field lacks an evidence-based model designed for this purpose. Accordingly, a state-level randomized controlled trial (N = 30 states) of a formal, theory-based approach for appropriately supporting policymakers' use of scientific evidence--known as the Research-to-Policy Collaborati... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/03/2025
Locations: Penn State University, University Park, Pennsylvania
Conditions: Substance Abuse, Substance Use Disorders, Prevention, Legislation, Use of Research Evidence
Register for Updates
Pain Self-Management and Treatment Engagement for Patients Taking Opioids
NCT06855732
Recruiting
The goal of this study is to learn if Pain Self-Management (PSM) can improve chronic pain care in individuals with opioid misuse or opioid use disorder (OUD) The main questions it aims to answer are: * Does PSM help participants manage their chronic pain more effectively? * Does PSM help participants engage in treatment for opioid use? Researchers will compare PSM to standard care to see if PSM is effective in managing chronic pain and engagement in treatment. Participants will: * Take part... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Community Medicine, Inc., Pittsburgh, Pennsylvania
Conditions: Chronic Pain, Opioid Use Disorder, Opioid Misuse and Addiction
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Brief Behavioral Sleep Intervention for Obesity Prevention in Primary Care
NCT06810557
Recruiting
The goal of this study is to compare two different approaches to help families with children 6-11 years enhance nighttime sleep: 1) working one-on-one with a nurse to learn effective behavioral strategies to try to improve children's sleep or 2) receiving education on a good night's sleep and its benefits. Participating families will meet with a nurse 6 times or receive 6 educational handouts. Participating families will also complete three assessments (start of the study, 2 months and 6 months)... Read More
Gender:
ALL
Ages:
Between 6 years and 11 years
Trial Updated:
03/03/2025
Locations: Temple Pediatrics, Philadelphia, Pennsylvania
Conditions: Obesity, Childhood, Short Sleep, Obesity Prevention
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Next-Generation Photon-Counting CT Technology: Development and Clinical Evaluation
NCT06691659
Recruiting
This project aims to develop and evaluate a next-generation photon-counting CT prototype, and assess whether next-generation photon-counting CT--which enables reduced radiation dose, high spatial resolution, and spectral imaging--would facilitate improved diagnostic performance for abdominal, cardiothoracic, musculoskeletal, and neuroimaging.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
03/03/2025
Locations: University of Pennsylvania - Center for Advanced Computed Tomography Imaging Services (CACTIS), Philadelphia, Pennsylvania
Conditions: Radiation Protection, Image Enhancement
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Using an End-of-life Conversation Game to Engage Patients with Cancer in Advance Care Planning: Phase 2
NCT06384417
Recruiting
The goal of this clinical trial is to explore feasibility, acceptability, and effectiveness of end-of-life conversation game "Hello" as a tool to help individuals with various solid cancer types (including: breast, gastro-intestinal, lung, melanoma, head and neck, and/or genito-urinary cancers) treated at Penn State Health clinics and their loved ones perform advance care planning (ACP). The main questions it aims to answer are: What modifications and/or adaptations are necessary to Hello for u... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Penn State Cancer Institute, Hershey, Pennsylvania
Conditions: Breast Cancer, Lung Cancer, Genito-Urinary Cancer, Colorectal Cancer, Gastric Cancer, Pancreatic Cancer, Liver Cancer, Head and Neck Cancer, Melanoma
Register for Updates