Pennsylvania is currently home to 3295 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Physiological Effects of ANGPTL3 Variants in Humans
NCT04234724
Recruiting
To evaluate the role of ANGPTL3, on lipid metabolism. To explore the role of this protein on glucose metabolism.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Hypocholesterolemia
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Responsive Neurostimulation For Loss Of Control Eating
NCT03868670
Recruiting
The primary objective of this trial is to assess device function and safety, with secondary objectives including the feasibility.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
03/04/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Loss of Control Eating, Obesity, Morbid
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Neurofeedback for Treatment Resistant Depression
NCT03428828
Recruiting
The purpose of this study is to determine the clinical efficacy of real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) training to increase the amygdala's response to positive autobiographical memories in patients with depression who are considered treatment-resistant
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/04/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Treatment Resistant Depression
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Longitudinal Study of Neurodegenerative Disorders
NCT03333200
Recruiting
The purpose of this study is to understand the course of rare genetic disorders that affect the brain. This data is being analyzed to gain a better understanding of the progression of the rare neurodegenerative disorders and the effects of interventions.
Gender:
ALL
Ages:
All
Trial Updated:
03/04/2025
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: MLD, Krabbe Disease, ALD, MPS I, MPS II, MPS III, Vanishing White Matter Disease, GM3 Gangliosidosis, PKAN, Tay-Sachs Disease, NP Deficiency, Osteopetrosis, Alpha-Mannosidosis, Sandhoff Disease, Niemann-Pick Diseases, MPS IV, Gaucher Disease, GAN, GM1 Gangliosidoses, Morquio Disease, S-Adenosylhomocysteine Hydrolase Deficiency, Batten Disease, Pelizaeus-Merzbacher Disease, Leukodystrophy, Lysosomal Storage Diseases, Purine Nucleoside Phosphorylase Deficiency, Multiple Sulfatase Deficiency Disease
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Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts
NCT06856148
Recruiting
If science is to inform effective substance misuse prevention policy and ultimately improve public health, the field needs an effective strategy for directly supporting policymakers' use of research evidence, yet our field lacks an evidence-based model designed for this purpose. Accordingly, a state-level randomized controlled trial (N = 30 states) of a formal, theory-based approach for appropriately supporting policymakers' use of scientific evidence--known as the Research-to-Policy Collaborati... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/03/2025
Locations: Penn State University, University Park, Pennsylvania
Conditions: Substance Abuse, Substance Use Disorders, Prevention, Legislation, Use of Research Evidence
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Pain Self-Management and Treatment Engagement for Patients Taking Opioids
NCT06855732
Recruiting
The goal of this study is to learn if Pain Self-Management (PSM) can improve chronic pain care in individuals with opioid misuse or opioid use disorder (OUD) The main questions it aims to answer are: * Does PSM help participants manage their chronic pain more effectively? * Does PSM help participants engage in treatment for opioid use? Researchers will compare PSM to standard care to see if PSM is effective in managing chronic pain and engagement in treatment. Participants will: * Take part... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Community Medicine, Inc., Pittsburgh, Pennsylvania
Conditions: Chronic Pain, Opioid Use Disorder, Opioid Misuse and Addiction
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Brief Behavioral Sleep Intervention for Obesity Prevention in Primary Care
NCT06810557
Recruiting
The goal of this study is to compare two different approaches to help families with children 6-11 years enhance nighttime sleep: 1) working one-on-one with a nurse to learn effective behavioral strategies to try to improve children's sleep or 2) receiving education on a good night's sleep and its benefits. Participating families will meet with a nurse 6 times or receive 6 educational handouts. Participating families will also complete three assessments (start of the study, 2 months and 6 months)... Read More
Gender:
ALL
Ages:
Between 6 years and 11 years
Trial Updated:
03/03/2025
Locations: Temple Pediatrics, Philadelphia, Pennsylvania
Conditions: Obesity, Childhood, Short Sleep, Obesity Prevention
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Next-Generation Photon-Counting CT Technology: Development and Clinical Evaluation
NCT06691659
Recruiting
This project aims to develop and evaluate a next-generation photon-counting CT prototype, and assess whether next-generation photon-counting CT--which enables reduced radiation dose, high spatial resolution, and spectral imaging--would facilitate improved diagnostic performance for abdominal, cardiothoracic, musculoskeletal, and neuroimaging.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
03/03/2025
Locations: University of Pennsylvania - Center for Advanced Computed Tomography Imaging Services (CACTIS), Philadelphia, Pennsylvania
Conditions: Radiation Protection, Image Enhancement
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iCare4Me Transitions
NCT06167746
Recruiting
The goal of this randomized controlled trial is to examine the effect of a virtual face-to-face health coach intervention to improve self-care among caregivers of hospitalized older adults during care transitions compared to web-based resource information alone to determine the effectiveness of each intervention. The main questions it aims to answer are: 1. compare the efficacy of the virtual health coaching intervention vs. web-based information alone in improving self-care in caregivers of ho... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Pennsylvania Hospital, Philadelphia, Pennsylvania
Conditions: Caregiver Stress
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Study to Assess EN3835 in the Treatment of Plantar Fibromatosis (Also Known as Ledderhose Disease)
NCT06151197
Recruiting
This study will assess the efficacy, safety, and tolerability of EN3835 compared to placebo in the treatment of PFI (also known as Ledderhose disease).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Endo Site 10, Altoona, Pennsylvania
Conditions: Plantar Fibromatosis, Ledderhose Disease
Register for Updates
Feasibility of a Mindfulness Intervention for Endometriosis Surgery
NCT06141720
Recruiting
Endometriosis is a common cause of pelvic pain in women which has been historically under-studied and under-diagnosed. The goal of this research is to pilot-test the feasibility and acceptability of a manualized, single-session brief mindfulness-based intervention (BMBI) among participants with endometriosis-related chronic pelvic pain (ECPP) who undergo surgical treatment, and gather preliminary data necessary for future studies assessing BMBI's impact on outcomes in surgically-treated ECPP. Th... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Penn State Health, Hershey, Pennsylvania
Conditions: Endometriosis, Pain, Mindfulness
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Safety Study for a Gamma Delta T Cell Product Used with Low Dose Radiotherapy in Patients with Locally Advanced or Metastatic NSCLC or Solid Tumors with Bone Metastases
NCT06069570
Recruiting
This is a clinical trial studying intravenous infusions of allogeneic gamma delta T cells after receiving low dose radiotherapy in participants with locally advanced or metastatic non-small cell lung cancer or solid tumors with bone metastases to evaluate the safety and efficacy of combining immunotherapy with radiation therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Carcinoma, Non-Small-Cell Lung Cancer, Bone Metastases from Solid Tumors
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