Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
RZ358 Treatment for Congenital Hyperinsulinism
NCT06208215
Recruiting
The Phase 3 pivotal study is designed to evaluate the efficacy and safety of RZ358 for the treatment of congenital hyperinsulinism (HI) as add-on to standard-of-care (SOC) therapy compared to SOC alone over 24 weeks and to evaluate the longer-term safety and efficacy of RZ358 during a subsequent open-label extension (OLE) period.
Gender:
ALL
Ages:
Between 3 months and 45 years
Trial Updated:
03/04/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Congenital Hyperinsulinism
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A PIVOTAL STUDY EVALUATING SAFETY and EFFICACY of the SHIRATRONICS MIGRAINE THERAPY SYSTEM
NCT06167655
Recruiting
Prospective, multi-center, double blind, randomized, sham-controlled study to evaluate neuromodulation in patient with chronic migraine. The study hypothesis to be tested is the mean reduction in mean monthly headache days between patients in treatment versus sham.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/04/2025
Locations: Argires Marotti Neurological Associates, Lancaster, Pennsylvania
Conditions: Headache Migraine Chronic
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Preserving Geriatric Muscle With an Osteoporosis Medication
NCT06118905
Recruiting
Our goal is to demonstrate efficacy of the novel agent Denosumab to improve or preserve muscle health, strength, mobility and function in frail older adults.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/04/2025
Locations: St. Barnabas Woodlands, Pittsburgh, Pennsylvania
Conditions: Osteoporosis
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CTNNA1 Familial Expansion Study
NCT05126290
Recruiting
The goal of the CAFÉ Study is to determine the cancer risks associated with germline CTNNA1 loss-of-function variants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Cancer Gene Mutation, Gastric Cancer, Breast Cancer
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Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases
NCT05029336
Recruiting
A subset of autoimmune diseases (ADs) in children and young adults are life-threatening and unresponsive to conventional treatments. In these patients, the delivery of high dose immunosuppressive therapy followed by autologous stem cell transplant (ASCT) offers a treatment strategy capable of purging the pathogenic, autoreactive immune system and an opportunity for "immune reset." This strategy has been used in adults across a myriad of indications with evidence for efficacy. This study proposes... Read More
Gender:
ALL
Ages:
Between 8 years and 25 years
Trial Updated:
03/04/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Systemic Lupus Erythematosus, Systemic Sclerosis
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Nilotinib Plus Dabrafenib/Trametinib or Encorafenib/Binimetinib in Metastatic Melanoma
NCT04903119
Recruiting
This is a phase 1 dose-escalation study of nilotinib in combination with fixed-dose dabrafenib and trametinib regimen for patients with metastatic or unresectable melanoma carrying a BRAF V600 mutation and have relapsed on a BRAF/MEK inhibitor therapy. The goal is to assess the toxicity and tolerability and determine the maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D) of the combination of nilotinib with dabrafenib and trametinib or with encorafenib and binimetinib. Additionally, th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: St. Luke's University Health Network, Easton, Pennsylvania
Conditions: Metastatic Melanoma, BRAF Gene Mutation
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Shared Decision-making and Colorectal Cancer Screening
NCT04748380
Recruiting
Conduct a feasibility pilot RCT of a newly developed colorectal cancer screening (CRC) decision aid (DA) including 66 LHL adults 76-85 years recruited from community health centers. Hypotheses: Patients in the intervention group will be more likely to change their intentions to be screened with fewer patients with \<10 year LE and/or those with \>10 year LE and no risk factors intending to be screened and more with \>10 year LE and risk factors for CRC and/or those who have never been screened i... Read More
Gender:
ALL
Ages:
Between 75 years and 85 years
Trial Updated:
03/04/2025
Locations: University of Pennsylvania Health System, Philadelphia, Pennsylvania
Conditions: Colorectal Cancer
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Trial of Vision Therapy for Intermittent Exotropia
NCT04487249
Recruiting
The main objective of this randomized trial comparing vision therapy to observation is to determine the short-term effectiveness of vision therapy on distance intermittent exotropia control. The results will help determine whether to proceed to a full-scale, long-term randomized trial.
Gender:
ALL
Ages:
Between 8 years and 16 years
Trial Updated:
03/04/2025
Locations: Salus University, Philadelphia, Pennsylvania
Conditions: Intermittent Exotropia
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Physiological Effects of ANGPTL3 Variants in Humans
NCT04234724
Recruiting
To evaluate the role of ANGPTL3, on lipid metabolism. To explore the role of this protein on glucose metabolism.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Hypocholesterolemia
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Responsive Neurostimulation For Loss Of Control Eating
NCT03868670
Recruiting
The primary objective of this trial is to assess device function and safety, with secondary objectives including the feasibility.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
03/04/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Loss of Control Eating, Obesity, Morbid
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Neurofeedback for Treatment Resistant Depression
NCT03428828
Recruiting
The purpose of this study is to determine the clinical efficacy of real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) training to increase the amygdala's response to positive autobiographical memories in patients with depression who are considered treatment-resistant
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/04/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Treatment Resistant Depression
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Longitudinal Study of Neurodegenerative Disorders
NCT03333200
Recruiting
The purpose of this study is to understand the course of rare genetic disorders that affect the brain. This data is being analyzed to gain a better understanding of the progression of the rare neurodegenerative disorders and the effects of interventions.
Gender:
ALL
Ages:
All
Trial Updated:
03/04/2025
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: MLD, Krabbe Disease, ALD, MPS I, MPS II, MPS III, Vanishing White Matter Disease, GM3 Gangliosidosis, PKAN, Tay-Sachs Disease, NP Deficiency, Osteopetrosis, Alpha-Mannosidosis, Sandhoff Disease, Niemann-Pick Diseases, MPS IV, Gaucher Disease, GAN, GM1 Gangliosidoses, Morquio Disease, S-Adenosylhomocysteine Hydrolase Deficiency, Batten Disease, Pelizaeus-Merzbacher Disease, Leukodystrophy, Lysosomal Storage Diseases, Purine Nucleoside Phosphorylase Deficiency, Multiple Sulfatase Deficiency Disease
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