Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts
NCT06856148
Recruiting
If science is to inform effective substance misuse prevention policy and ultimately improve public health, the field needs an effective strategy for directly supporting policymakers' use of research evidence, yet our field lacks an evidence-based model designed for this purpose. Accordingly, a state-level randomized controlled trial (N = 30 states) of a formal, theory-based approach for appropriately supporting policymakers' use of scientific evidence--known as the Research-to-Policy Collaborati... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/03/2025
Locations: Penn State University, University Park, Pennsylvania
Conditions: Substance Abuse, Substance Use Disorders, Prevention, Legislation, Use of Research Evidence
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Pain Self-Management and Treatment Engagement for Patients Taking Opioids
NCT06855732
Recruiting
The goal of this study is to learn if Pain Self-Management (PSM) can improve chronic pain care in individuals with opioid misuse or opioid use disorder (OUD) The main questions it aims to answer are: * Does PSM help participants manage their chronic pain more effectively? * Does PSM help participants engage in treatment for opioid use? Researchers will compare PSM to standard care to see if PSM is effective in managing chronic pain and engagement in treatment. Participants will: * Take part... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Community Medicine, Inc., Pittsburgh, Pennsylvania
Conditions: Chronic Pain, Opioid Use Disorder, Opioid Misuse and Addiction
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Brief Behavioral Sleep Intervention for Obesity Prevention in Primary Care
NCT06810557
Recruiting
The goal of this study is to compare two different approaches to help families with children 6-11 years enhance nighttime sleep: 1) working one-on-one with a nurse to learn effective behavioral strategies to try to improve children's sleep or 2) receiving education on a good night's sleep and its benefits. Participating families will meet with a nurse 6 times or receive 6 educational handouts. Participating families will also complete three assessments (start of the study, 2 months and 6 months)... Read More
Gender:
ALL
Ages:
Between 6 years and 11 years
Trial Updated:
03/03/2025
Locations: Temple Pediatrics, Philadelphia, Pennsylvania
Conditions: Obesity, Childhood, Short Sleep, Obesity Prevention
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Next-Generation Photon-Counting CT Technology: Development and Clinical Evaluation
NCT06691659
Recruiting
This project aims to develop and evaluate a next-generation photon-counting CT prototype, and assess whether next-generation photon-counting CT--which enables reduced radiation dose, high spatial resolution, and spectral imaging--would facilitate improved diagnostic performance for abdominal, cardiothoracic, musculoskeletal, and neuroimaging.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
03/03/2025
Locations: University of Pennsylvania - Center for Advanced Computed Tomography Imaging Services (CACTIS), Philadelphia, Pennsylvania
Conditions: Radiation Protection, Image Enhancement
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iCare4Me Transitions
NCT06167746
Recruiting
The goal of this randomized controlled trial is to examine the effect of a virtual face-to-face health coach intervention to improve self-care among caregivers of hospitalized older adults during care transitions compared to web-based resource information alone to determine the effectiveness of each intervention. The main questions it aims to answer are: 1. compare the efficacy of the virtual health coaching intervention vs. web-based information alone in improving self-care in caregivers of ho... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Pennsylvania Hospital, Philadelphia, Pennsylvania
Conditions: Caregiver Stress
Register for Updates
Study to Assess EN3835 in the Treatment of Plantar Fibromatosis (Also Known as Ledderhose Disease)
NCT06151197
Recruiting
This study will assess the efficacy, safety, and tolerability of EN3835 compared to placebo in the treatment of PFI (also known as Ledderhose disease).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Endo Site 10, Altoona, Pennsylvania
Conditions: Plantar Fibromatosis, Ledderhose Disease
Register for Updates
Feasibility of a Mindfulness Intervention for Endometriosis Surgery
NCT06141720
Recruiting
Endometriosis is a common cause of pelvic pain in women which has been historically under-studied and under-diagnosed. The goal of this research is to pilot-test the feasibility and acceptability of a manualized, single-session brief mindfulness-based intervention (BMBI) among participants with endometriosis-related chronic pelvic pain (ECPP) who undergo surgical treatment, and gather preliminary data necessary for future studies assessing BMBI's impact on outcomes in surgically-treated ECPP. Th... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Penn State Health, Hershey, Pennsylvania
Conditions: Endometriosis, Pain, Mindfulness
Register for Updates
Safety Study for a Gamma Delta T Cell Product Used with Low Dose Radiotherapy in Patients with Locally Advanced or Metastatic NSCLC or Solid Tumors with Bone Metastases
NCT06069570
Recruiting
This is a clinical trial studying intravenous infusions of allogeneic gamma delta T cells after receiving low dose radiotherapy in participants with locally advanced or metastatic non-small cell lung cancer or solid tumors with bone metastases to evaluate the safety and efficacy of combining immunotherapy with radiation therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Carcinoma, Non-Small-Cell Lung Cancer, Bone Metastases from Solid Tumors
Register for Updates
Study of LP-184 in Patients with Advanced Solid Tumors
NCT05933265
Recruiting
The primary objective of this study is to evaluate the safety, tolerability, MTD and RP2D of LP-184 in patients with advanced solid tumors who have relapsed from or are refractory to standard therapy or for whom no standard therapy is available. The secondary objectives are to characterize the PK of LP-184 and its metabolites in plasma and assess clinical activity of LP-184. Participants will receive LP-184 infusion during Day 1 and Day 8 of each 21-day cycle, for a minimum of two cycles. Patie... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Advanced Solid Tumor, Metastatic Solid Tumor, GBM, TNBC - Triple-Negative Breast Cancer, NSCLC, Pancreatic Adenocarcinoma, DDR Gene Mutation
Register for Updates
Healthy Mom Zone Gestational Weight Gain Management Intervention 2.0
NCT05807594
Recruiting
The goal of this clinical trial is to see if the enhanced HMZ 2.0 intervention with new control system/digital platform to regulate gestational weight gain (GWG) and impact maternal-infant outcomes while collecting implementation data works and can be given to other pregnant women in various settings. The question this study aims to answer are: 1. Does the new intervention manage GWG? 2. Does the new intervention have any influence on sleep and eating behaviors and infant outcomes. 3. Does the... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
03/03/2025
Locations: Pennsylvania State University, University Park, Pennsylvania
Conditions: Gestational Weight Gain, Overweight and Obesity, Pregnancy, Energy Balance
Register for Updates
Poly-omic Predictors of Symptom Duration and Recovery for Adolescent Concussion
NCT04582682
Recruiting
The purpose of this study is to identify changes in salivary micro ribonucleic acid (miRNA) levels that are predictive of symptom duration and character following mild traumatic brain injury (mTBI) in children.
Gender:
ALL
Ages:
Between 13 years and 18 years
Trial Updated:
03/03/2025
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Concussion, Mild
Register for Updates
HOPS Study: A Conceptual Replication
NCT04465708
Recruiting
The purpose of this current study is to conduct a conceptual replication with an independent evaluation team of the randomized controlled trial conducted by Langberg and colleagues, which demonstrated the efficacy of the Homework, Organization, and Planning Skills (HOPS) intervention. The study will be conducted under routine practice conditions with school staff serving as interventionists; the study sample will include the broad range of students with organization, time management, and plannin... Read More
Gender:
ALL
Ages:
Between 11 years and 15 years
Trial Updated:
03/03/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Executive Dysfunction, Attention Deficit Hyperactivity Disorder
Register for Updates