Pennsylvania is currently home to 3302 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness
NCT04471909
Recruiting
Prospective, non-randomized, multi-center clinical investigation of the NEXUS™ Aortic Arch Stent Graft System (NEXUSTM) for the treatment of thoracic aortic lesions involving the aortic arch with a proximal landing zone, native or previously implanted surgical graft, in the ascending aorta and with a brachiocephalic trunk native landing zone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/11/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
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GFRα4 CAR T Cells in MTC Patients
NCT04877613
Recruiting
This is an open-label phase 1 study to assess the safety and feasibility of autologous T cells expressing a single-chain scFv targeting GFRα4 with tandem TCR/CD3ζ and 4-1BB (TCRζ/4-1BB) co-stimulatory domains (referred to as "CART-GFRa4 cells") in patients with incurable medullary thyroid cancer (MTC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/10/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Metastatic Medullary Thyroid Cancer, Recurrent Thyroid Gland Medullary Carcinoma
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International CDKL5 Registry
NCT04486768
Recruiting
Owing to the recent classification of CDKL5 Deficiency Disorder (CDD) as a unique disorder, there is a limited understanding of overall disease natural history and meaningful outcome measures. An international patient registry aimed at collecting both patient/caregiver and clinician-entered demographic, patient-reported outcome (PRO) and treatment data would benefit both the scientific and patient communities. This CDD registry will follow up to 500 patients diagnosed with CDD over several years... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/10/2024
Locations: University of Pennsylvania Orphan Disease Center, Philadelphia, Pennsylvania
Conditions: CDKL5 Deficiency Disorder (CDD)
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Pilot Trial of the RUBI Program for Autistic Adults
NCT06593613
Recruiting
The goal of this clinical trial is to evaluate if a redesigned version of the RUBI parenting intervention can reduce challenging behaviors and improve adaptive skills in autistic adults with co-occurring challenging behaviors. The main questions it aims to answer are: * Is the redesigned RUBI intervention feasible and acceptable for autistic adults and their families? * Does the redesigned RUBI intervention reduce challenging behaviors and enhance the quality of life for autistic adults? * Rese... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: A.J. Drexel Autism Institute, Philadelphia, Pennsylvania
Conditions: Autism Spectrum Disorder, Behavior, Parenting
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Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial Hypertension
NCT06543745
Recruiting
The purpose of the study is to learn more about how low-resistance training impacts frailty and the quality of life of people with pulmonary arterial hypertension (PAH). Low-resistance training is an evidence-based approach that may help patients improve their functional ability.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: University of Pennsyvania, Philadelphia, Pennsylvania
Conditions: Pulmonary Arterial Hypertension, Frailty
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First In Human Study of CX-801 in Advanced Solid Tumors
NCT06462794
Recruiting
The purpose of this first-in-human study, CTMX-801-101, is to characterize the safety, tolerability, and antitumor activity of CX-801 as monotherapy and in combination with pembrolizumab in adult participants with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: University of Pittsburgh Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Solid Tumor, Adult
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The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial
NCT05446272
Recruiting
DIVA is a pragmatic randomized clinical trial (RCT) to determine: among (P) preterm infants born 23 0/7-28 6/7 weeks gestation undergoing extubation from mechanical ventilation, whether (I) Non-invasive neurally adjusted ventilatory assist (NIV-NAVA) (C) compared with Non-synchronized nasal intermittent positive pressure ventilation (NS-NIPPV), will reduce the incidence of (O) extubation failure within (T) 5 days (120 hours) of extubation.
Gender:
ALL
Ages:
Between 0 days and 9 weeks
Trial Updated:
09/09/2024
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Extubation Failure, Bronchopulmonary Dysplasia, Death
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Romosozumab Use to Build Skeletal Integrity
NCT05058976
Recruiting
The purpose of this study is to find out if one year of romosozumab (Evenity®), a monthly injection given in the arm under the skin, prior to an infusion of zoledronic acid Reclast®, works to treat bone loss and prevent it from worsening in older women (ages 65 and older) who have osteoporosis and reside in long-term care (LTC) facilities.
Gender:
FEMALE
Ages:
65 years and above
Trial Updated:
09/09/2024
Locations: UPMC Senior Communities, Pittsburgh, Pennsylvania
Conditions: Osteoporosis, Osteoporosis, Postmenopausal, Osteoporosis Fracture
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Microsampling Assays for Immunosuppressive Drugs in Children
NCT04989686
Recruiting
Immunosuppressive therapy is used to treat and manage solid organ and bone marrow/stem cell transplants in children. However, it can be harmful if too little or too much is given. Monitoring immunosuppressive drug (cyclosporine A, tacrolimus, and sirolimus) concentrations in the blood is important to ensure that the drug is given safely and effectively, but current approaches for collecting blood from a vein are painful and often difficult in children. Investigators seek to compare a new approac... Read More
Gender:
ALL
Ages:
17 years and below
Trial Updated:
09/09/2024
Locations: Children's Hospital of Phildelphia, Philadelphia, Pennsylvania
Conditions: Immunosuppression
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Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers
NCT04416568
Recruiting
This clinical trial is studying two immunotherapy drugs (nivolumab and ipilimumab) given together as a possible treatment for INI1-negative tumors.
Gender:
ALL
Ages:
Between 6 months and 40 years
Trial Updated:
09/09/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Malignant Rhabdoid Tumor, Rhabdoid Tumor of the Kidney, Epithelioid Sarcoma, Chordoma (Poorly Differentiated or De-differentiated), Atypical Teratoid/Rhabdoid Tumor, Other INI1 Negative Tumors (With PI Approval), Other SMARCA4-deficient Malignant Tumors (With PI Approval)
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Fiber Food Introduction in Pediatric Short Bowel Syndrome
NCT05432648
Recruiting
Short bowel syndrome (SBS) is a rare but challenging condition in which patients have insufficient bowel length to meet fluid, electrolyte, and nutrient requirements without parenteral support. The purpose of this study is to determine how well dietary fiber is tolerated in patients with short bowel syndrome compared to patients without short bowel syndrome based on assessment of gastrointestinal symptoms, and corresponding changes in microbiome composition and metabolomics.
Gender:
ALL
Ages:
Between 4 months and 18 years
Trial Updated:
09/06/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Short Gut Syndrome
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Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer Plus Intranodal DC Vaccines
NCT02432378
Recruiting
This study will evaluate the immunologic and potential clinical effectiveness of intensive locoregional sequential intraperitoneal (IP) cisplatin (IPC) with intravenous (iv) paclitaxel followed by peritoneal infusion of a chemokine modulatory (CKM) regimen composed of a cocktail of IP rintatolimod and interferon-alpha (IFNα) for patients with advanced stage ovarian cancer (III-IV) at primary neoadjuvant setting. In the safety phase I phase, we determined the tolerable dose of IPC-CKM. In this p... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/06/2024
Locations: UPMC CancerCenter at Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania
Conditions: Cancer of Ovary, Cancer of the Ovary, Neoplasms, Ovarian, Ovarian Cancer, Ovary Cancer, Ovary Neoplasms
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