Pennsylvania is currently home to 3308 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy
NCT05476276
Recruiting
This is a Platform Protocol to perform Phase II clinical trials in The Early Phase Pain Investigation Clinical Network (EPPIC-Net), under The Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM, related to the treatment of Painful Diabetic Peripheral Neuropathy (PDPN) in a platform setting to test multiple assets under a single protocol.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Painful Diabetic Neuropathy
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Loncastuximab Tesirine in Combination With Rituximab in Patients With Relapsed or Refractory Follicular Lymphoma
NCT04998669
Recruiting
The purpose of this research is to see if Loncastuximab Tesirine in combination with Rituximab will result in higher complete response rate when given to treat follicular lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2024
Locations: Allegheny Health Network, Pittsburgh, Pennsylvania
Conditions: Follicular Lymphoma
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Abbreviate or FAST Breast MRI for Supplemental Breast Cancer Screening for Black Women at Average Risk and Dense Breasts
NCT04854304
Recruiting
500 patients will be prospectively recruited to undergo a fast breast MRI examination. The women will be recruited for the study will meet the following criteria: 1. African American 2. negative DBT examination 11 months prior to recruitment 3. Heterogeneously and Extremely breast densities 4. clinically asymptomatic- no palpable masses, focal thickening or clinically significant discharge. Investigators will identify these patients EPIC database utilizing the date of their last mammogram. Inter... Read More
Gender:
FEMALE
Ages:
Between 40 years and 75 years
Trial Updated:
08/20/2024
Locations: UPENN, Philadelphia, Pennsylvania
Conditions: Breast Diseases
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Disentangling the Role of Depression in Hypersomnia
NCT05850676
Recruiting
Individuals who have disorders of hypersomnolence (excessive sleepiness) often report symptoms of depression. The goal of this study is to further understand of the relationship between depression and hypersomnia by examining mood-relevant domains of slow wave sleep and reward function.
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
08/19/2024
Locations: The University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Hypersomnia
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CureDuchenne Link®: A Resource for Research
NCT04972604
Recruiting
CureDuchenne link is a data hub comprised of integrated biospecimens, clinical data, and self- and/or caregiver-reported information from participants. Anyone over 4 weeks old who has been diagnosed with DMD or BMD or who is a carrier of DMD or BMD can join. Parents or legal guardians can sign up their child(ren).
Gender:
ALL
Ages:
4 weeks and above
Trial Updated:
08/19/2024
Locations: Penn State Health, Hershey, Pennsylvania
Conditions: Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
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Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
NCT03876054
Recruiting
The REALITY study is a prospective, post-market, non-randomized, multi-center, single-arm, open-label study intended to collect short- and long-term safety and effectiveness data on various populations implanted with Abbott's neurostimulation systems.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2024
Locations: Center for Interventional Pain & Spine, Exton, Pennsylvania
Conditions: Chronic Pain
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Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound
NCT03192436
Recruiting
Neuromodulation is a fast growing field that offers a wide range of applications for both understanding and treating the brain. Future research for non-invasive neuromodulation will need to elucidate the optimal frequency, duration, and intensity of stimulation for a variety of technologies and diseases. Closed loop stimulation is thus a promising research area that allows for responsive stimulation and real time symptom management. Our project is proposed to develop and test a novel noninvasive... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
08/19/2024
Locations: Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania
Conditions: Healthy
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Childhood Cancer Survivor Study
NCT01120353
Recruiting
The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic mod... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/19/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Cancer
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Strategy Training for Individuals With Unilateral Neglect
NCT06400147
Recruiting
It is common for individuals after stroke to have a cognitive perceptual impairment called unilateral spatial neglect (neglect). Individuals with neglect have difficulty paying attention to one side of their body or one side of the environment and therefore experience difficulty performing daily activities. There are a lack of effective treatments for neglect and new interventions are needed to help reduce disability for these individuals. Metacognitive strategy training (strategy training) is a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/16/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Stroke, Neglect, Hemispatial
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Development of 3D Multi-Parametric Ultrasound (MPUS) as a Decision Support Tool for Patients
NCT05705219
Recruiting
This clinical trial studies how well 3-dimensional multi-parametric ultrasound (3D MPUS) imaging works as a decision-support tool for patients with liver tumors undergoing therapy. Continuous and dynamic imaging of patients undergoing therapy is required to monitor early-phase treatment response. 3D-MPUS is an inexpensive and safe method, which may provide complementary quantitative functional (perfusion) and tissue characterization information to anatomical radiological assessment or blood biom... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/16/2024
Locations: Thomas Jefferson Hospital, Philadelphia, Pennsylvania
Conditions: Liver Cancer, Adult
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Telephone All Nations Breath of Life
NCT04764175
Recruiting
This project formally test an individual, telephone-based version of the All Nations Breath of Life smoking cessation program (tANBL) for American Indians (AI) for efficacy versus an untailored comparison program (CP). The primary outcome is 7-day point prevalence abstinence from smoking cigarettes at 6 months post-baseline. Secondarily, the study examines continuous abstinence and reduction in smoking at both 6 and 12 months post-baseline, as well as demographic predictors of cessation and/or r... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/16/2024
Locations: Lehigh University, Bethlehem, Pennsylvania
Conditions: Smoking Cessation
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Driver Education Research Study
NCT06413927
Recruiting
This study will test the effectiveness of different types of driver training interventions for reducing young new driver crash risk early after licensure.
Gender:
ALL
Ages:
Between 16 years and 17 years
Trial Updated:
08/15/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Risk Reduction Behavior, Injuries, Accident, Traffic, Development, Adolescent
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