Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies
NCT05476770
Recruiting
Tagraxofusp is a protein-drug conjugate consisting of a diphtheria toxin redirected to target CD123 has been approved for treatment in pediatric and adult patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). This trial aims to examine the safety of this novel agent in pediatric patients with relapsed/refractory hematologic malignancies. The mechanism by which tagraxofusp kills cells is distinct from that of conventional chemotherapy. Tagraxofusp directly targets CD123 that is pre... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
12/04/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Hematologic Malignancy, AML, ALL, BPDCN, MDS, Lymphoblastic Lymphoma, Lymphoma, B-Cell, Lymphoma, T-Cell, Hodgkin Lymphoma, Mixed Phenotype Acute Leukemia, Acute Undifferentiated Leukemia
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A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer
NCT05361174
Recruiting
This is a study to investigate the efficacy and safety of an infusion of IOV-4001 in adult participants with unresectable or metastatic melanoma or advanced non-small-cell lung cancer (NSCLC).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/04/2024
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Unresectable Melanoma, Metastatic Melanoma, Stage III Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
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Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults
NCT05108818
Recruiting
Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize that humans with different birth years will mount antibody and cellular responses of different specificities following seasonal influenza vaccination.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/04/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Influenza, Human
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HoFH, the International Clinical Collaborators Registry
NCT04815005
Recruiting
Homozygous familial hypercholesterolemia (HoFH), a rare inherited disorder caused by bi-allelic mutations in the LDL Receptor pathway, is characterized by extremely elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth and premature atherosclerotic cardiovascular disease (ASCVD). Our current knowledge about HoFH is disjointed and largely stems from relatively small case series and expert opinion. HICC (Homozygous FH International Clinical Collaborators) is a global consortium... Read More
Gender:
ALL
Ages:
All
Trial Updated:
12/04/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Homozygous Familial Hypercholesterolemia
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Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation
NCT03721822
Recruiting
The purpose of this research is to measure the extent of lung inflammation between different groups of participants using a radioactive tracer called \[18F\]NOS. A radioactive tracer is a type of imaging drug that is labeled with a radioactive tag and injected into the body.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
12/04/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Smoking, Cigarette, Smoking E-cigarette, Healthy Volunteer
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Efficacy of Sodium Glucose Transporter Inhibitor (SGLT2I) in Adult Patients with Congenital Heart Disease
NCT06260059
Recruiting
The goal of the study is to investigate the feasibility and benefit of novel guideline-directed heart failure therapy drug Empagliflozin (Jardiance) for adult patients with congenital heart disease (ACHD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Magee Women's Hospital, Pittsburgh, Pennsylvania
Conditions: Adult Congenital Heart Disease, Heart Failure
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4D-150 in Patients With Diabetic Macular Edema
NCT05930561
Recruiting
Phase 2 randomized, active-controlled, double-masked, dose-ranging trial in adults with Diabetic Macular Edema (DME).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Erie Retina Research, Erie, Pennsylvania
Conditions: Diabetic Macular Edema, Diabetic Retinopathy
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The Path to Optimal Black Maternal Heart Health: Comparing Two CVD Risk Reduction Interventions (Change of HEART)
NCT05499507
Recruiting
The overarching goal of our proposal is to reduce disparities in perinatal cardiovascular disease risk factors among Black women utilizing a community-driven, social ecological framework.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Temple University/Temple Health, Philadelphia, Pennsylvania
Conditions: Pregnancy Related, Hypertension, Obesity, Racism
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Obesity and Pediatric Multiple Sclerosis
NCT04593082
Recruiting
Obesity is one possible contributor to severity of multiple sclerosis and progression of the disease. We already know that obesity is a risk determinant for acquiring MS, yet the impact of obesity on pediatric MS disease expression and course is unknown. This study will evaluate the relationship between obesity, obesity-derived inflammatory mediators, and imaging metrics of MS severity in children. Understanding how childhood obesity contributes to MS severity/progression may yield fundamental i... Read More
Gender:
ALL
Ages:
Between 10 years and 20 years
Trial Updated:
12/03/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Multiple Sclerosis
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Does Vaginal Delivery of Combined Hormonal Contraception Affect the Risk of Metabolic Syndrome in Overweight/obese Women with PCOS
NCT04257500
Recruiting
A prospective study to determine the metabolic effects of the contraceptive vaginal ring among overweight and obese women with polycystic ovary syndrome (PCOS). We will recruit a total of 40 participants and study use of the vaginal ring over a 4-month period.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
12/03/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Polycystic Ovary Syndrome
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Optimizing Tobacco Use Treatment for PLWHA
NCT04176172
Recruiting
The advent of anti-retroviral therapy (ART) for people living with HIV/AIDS (PLWHA) substantially improved life expectancy but has also led to the critical need to address modifiable risk factors associated with cancer and cardiovascular disease, such as tobacco smoking. HIV-infected smokers lose more life-years due to tobacco use than they do to their HIV infection. There have been relatively few studies of tobacco use treatments for PLWHA and systematic reviews show that there are insufficien... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: HIV/AIDS, Nicotine Dependence
Register for Updates
Inositol Supplementation to Treat PCOS (INSUPP-PCOS)
NCT03864068
Recruiting
To determine if Inositol, a dietary supplement, will improve ovarian and adrenal androgen excess in women with Polycystic Ovarian Syndrome(PCOS).
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
12/03/2024
Locations: Penn State College of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Polycystic Ovary Syndrome, Anovulation, Hyperandrogenism, Insulin Resistance, Glucose Intolerance, Metabolic Complication
Register for Updates