Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
MASA Valve Early Feasibility Study
NCT05452720
Recruiting
The MASA Valve Early Feasibility Study (MVEFS) multi-site interventional clinical trial within the United States of America with each center following a common protocol.The objective of the trial is to evaluate the safety and probable benefit of MASA Valve in the indicated subset of patients requiring Right Ventricular Outflow Tract Reconstruction (RVOTR). As an early feasibility study, the purpose is determine the feasibility of success of the device in order to gather early data towards a futu... Read More
Gender:
ALL
Ages:
Between 0 years and 22 years
Trial Updated:
11/04/2024
Locations: Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Tetrology of Fallot, Pulmonary Stenosis, Truncus Arteriosus, Transposition of Great Vessels, Pulmonary Atresia, Ross Procedure
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Endometriosis and Microvascular Dysfunction: Role of Inflammation
NCT05069740
Recruiting
The purpose of this study is to better understand the underlying mechanisms associated with elevated cardiovascular disease risk in women with endometriosis, and to measure the effectiveness of emerging endometriosis treatments on outcomes specific to cardiovascular dysfunction. Epidemiologic data demonstrate a clear association between endometriosis, reproductive risk factors, inflammation and cardiovascular (CV) risk. Circulating factors, low-density lipoprotein (LDL) and oxidized LDL (oxLDL)... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
11/04/2024
Locations: The Pennsylvania State University, University Park, Pennsylvania
Conditions: Endometriosis
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Proteomics and Radiomics Research of Breast Cancer Markers in Tissue, Interstitial Fluid and Serum
NCT01042548
Recruiting
The current study is a case control study involving comparisons of tissue interstitial fluid from breast cancer and adjacent non-cancerous tissue as well as that from benign breast lesion and its adjacent non-diseased tissue for a distinguishable breast cancer profile. The purpose of this research is to collect fresh breast nodule/cancer and surrounding non-cancerous tissue for proteomic studies of the interstitial fluid to identify a profile distinguishing breast cancer which will also permit f... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: UPMC St. Margaret, Pittsburgh, Pennsylvania
Conditions: Breast Cancer
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Angiotensin-(1-7) Cardiovascular Effects in Aging
NCT05301192
Recruiting
Aging is an independent risk factor for developing hypertension and cardiovascular disease; however, the mechanisms underlying age-related cardiovascular disease remain poorly understood. One hallmark of aging is an increase in sympathetic nervous system activity, which can decrease the number and/or sensitivity of β2 adrenergic receptors to reduce dilation of blood vessels and increase blood pressure. Identifying new targets to restore vascular β2 adrenergic receptor signaling may help reduce c... Read More
Gender:
ALL
Ages:
Between 65 years and 80 years
Trial Updated:
11/03/2024
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Aging
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fMRI in Postural Tachycardia Syndrome
NCT04137757
Recruiting
Postural tachycardia syndrome (POTS) is one of the most common forms of chronic orthostatic intolerance in the United States. This is a disabling disorder characterized by an excessive increase in heart rate upon standing that is accompanied by symptoms such as dizziness and fatigue. One of the most under appreciated and bothersome symptoms of POTS is impaired cognition or "brain fog," which occurs to a level that interferes with daily activities such as work and education. Despite this high imp... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
11/03/2024
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Postural Tachycardia Syndrome
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Angiotensin-(1-7) and Energy Expenditure in Human Obesity
NCT03777215
Recruiting
The objective of this study is to better define the role of the hormone angiotensin-(1-7) in energy balance. We will test the overall hypothesis that angiotensin-(1-7) increases resting energy expenditure and promotes markers of heat production (thermogenesis) in white adipose tissue in human obesity.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
11/03/2024
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Obesity
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A Multi-Site Clinical Evaluation of the LIAISON NES FLU A/B, RSV & COVID-19 Assay in Symptomatic Patients
NCT06672692
Recruiting
The DiaSorin Molecular LIAISON® NES FLU A/B, RSV \& COVID-19 real-time polymerase chain reaction (RT-PCR) assay is intended for use on the DiaSorin LIAISON® NES instrument for the in-vitro qualitative detection and differentiation of nucleic acid from influenza A, influenza B, RSV and SARS-CoV-2 virus from dry nasal swabs (NS) from human patients with signs and symptoms during the acute phase of respiratory tract infection in conjunction with clinical and epidemiological risk factors. The LIAIS... Read More
Gender:
ALL
Ages:
All
Trial Updated:
11/01/2024
Locations: PAS Research - Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Influenza a, Influenza B, RSV, COVID 19
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Observational, Passive Surveillance Program to Collect Information on Women and Their Offspring Exposed to MenQuadfi® During Pregnancy, in United States (US)
NCT04843111
Recruiting
Primary Objective: To assess maternal, obstetrical, pregnancy, and neonatal and infant outcomes among women vaccinated with MenQuadfi® during pregnancy or in the 30 days preceding their Last Menstrual Period (LMP).
Gender:
ALL
Ages:
All
Trial Updated:
11/01/2024
Locations: Pennsylvania Locations, Swiftwater, Pennsylvania
Conditions: Meningococcal Infection
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Neoadjuvant PD-1 Inhibitor Dostarlimab (TSR-042) Vs. Combination of Tim-3 Inhibitor Cobolimab (TSR-022) and PD-1 Inhibitor Dostarlimab (TSR-042) in Melanoma
NCT04139902
Recruiting
The purpose of this study is to test the effects of anti-PI-1 inhibitor (TSR-042) or anti-PD-1/anti-TIM-3 combination (TSR-042 / TSR-022) in patients with operable melanoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Melanoma Stage III, Melanoma Stage IV
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Genomic and Proteomic Analysis of Disease Progression in Idiopathic Pulmonary Fibrosis (IPF)
NCT00373841
Recruiting
The purpose of the study is to identify genetic and biologic markers that may predict the loss of lung function due to idiopathic pulmonary fibrosis. The studies will compare genetic and biologic markers of samples to changes in symptoms. The ultimate goal is to predict if or when patients are likely to experience a rapid decline in lung function due to disease progression.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2024
Locations: Michelle F MacPherson, Pittsburgh, Pennsylvania
Conditions: Idiopathic Pulmonary Fibrosis
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Dorothy P. and Richard P. Simmons Center for ILD Research Registry
NCT00258583
Recruiting
The purpose of this study is to place past, current, and future medical record information into the UPMC Simmons Center for Interstitial Lung Disease Research Registry.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2024
Locations: Michelle F MacPherson, Pittsburgh, Pennsylvania
Conditions: Lung Diseases, Interstitial
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Genetic Polymorphisms in Idiopathic Pulmonary Fibrosis (IPF)
NCT00258570
Recruiting
The purposes of this study are: * to determine if there are specific genetic traits that might explain why patients have developed pulmonary fibrosis; * to determine if specific genetic traits account for differing patterns of inflammation and scar tissue that has formed in the patient's lungs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Pulmonary Fibrosis
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