Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Neurophysiologic Biomarkers in Rett Syndrome
NCT05932589
Recruiting
The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are: * Do these biomarkers change during clinical changes in individuals with RTT? * Are biomarkers stable over time in clinically stable individuals? * Do these biomarkers correlate with severity of RTT? Participants will be asked to undergo an electroencephalogram (EEG) with measurements of Evoked Potentials (EP) to measure electrical activity... Read More
Gender:
FEMALE
Ages:
Between 1 year and 18 years
Trial Updated:
11/08/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Rett Syndrome, RTT, Rett Syndrome, Atypical
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First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors
NCT05277051
Recruiting
This is a first time in-human (FTIH) study designed to investigate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of GSK4381562 in participants with select loco-regionally recurrent solid tumors or metastatic solid tumors where curative or standard treatment options have been exhausted.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: GSK Investigational Site, Philadelphia, Pennsylvania
Conditions: Neoplasms
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Trial of an Alternative Cabozantinib Dosing Schedule in Metastatic Renal Cell Carcinoma and Neuroendocrine Tumors
NCT05263050
Recruiting
This is a multi-site, three-cohort phase II trial of cabozantinib for IMDC all-risk frontline metastatic renal cell carcinoma (mRCC) patients OR any line mRCC patients who have not previously been treated with cabozantinib, and patients with pancreatic or extra-pancreatic neuroendocrine tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Metastatic Renal Cell Carcinoma, Clear-cell Metastatic Renal Cell Carcinoma, Neuroendocrine Tumors, Carcinoid Tumor
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Innovative Prosthetic Systems for Pediatric Limb Loss to Accommodate Growth
NCT05230004
Recruiting
An immediate fit adjustable prosthetic system is being investigated for children. The age range being recruited is from 3 years up to 18 years old. Phase I of this study will involve developing a final prototype by conducting in-lab testing on children with limb loss. Phase II will involve a two month home trial to further evaluate the comfort and usability of the socket. Outcome measures include a PEQ-based questionnaire, socket pressure measures and gait analysis.
Gender:
ALL
Ages:
Between 3 years and 18 years
Trial Updated:
11/08/2024
Locations: Penn Medicine Rittenhouse, Philadelphia, Pennsylvania
Conditions: Limb Deficiencies, Pediatric ALL
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Cutaneous Hydration Assessment in SCD
NCT05210114
Recruiting
This study will validate the diagnostic accuracy of a cutaneous hydration sensor. This sensor will also be evaluated for its feasibility as a point-of-care device for the assessment of hydration status and its potential to guide hydration therapy in patients with sickle cell disease (SCD).
Gender:
ALL
Ages:
12 years and above
Trial Updated:
11/08/2024
Locations: UPMC Sickle Cell Clinic, Pittsburgh, Pennsylvania
Conditions: Sickle Cell Disease
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Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms
NCT04858256
Recruiting
The main purpose of this study is to determine the effectiveness of the study drug pacritinib in people with relapsed or refractory lymphoproliferative disorders.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: T-Cell Neoplasm, Lymphoproliferative Disorders
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Clinical and Basic Investigations Into Congenital Disorders of Glycosylation
NCT04199000
Recruiting
The purpose of this research is to study the natural history of congenital disorders of glycosylation and its causes and treatments.
Gender:
ALL
Ages:
All
Trial Updated:
11/07/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Congenital Disorders of Glycosylation
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A Phase I Dual Dose Escalation Study of Radiation and Nab-Paclitaxel in Patients With Unresectable and Borderline Resectable Pancreatic Cancer
NCT02207465
Recruiting
The investigators hypothesize that intensification of local therapy will lead to improvements in local control and survival in patients with unresectable and borderline resectable pancreatic cancer. We propose to do this by combining nab-paclitaxel concurrently with dose-escalated radiation therapy. In the first part of this phase I study (sub-trial 1), the nab-paclitaxel dose will be escalated while the radiation dose is held constant at a standardly accepted level. The use of this novel chemor... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/06/2024
Locations: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Locally Advanced Unresectable Pancreatic Cancer Treated With Chemoradiotherapy, Borderline Resectable Pancreatic Cancer Treated With Chemoradiotherapy
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Interoception and Eating Behaviors in Children
NCT06504654
Recruiting
The purpose of this study is to examine how individual differences in interoception (the ability to sense, interpret, and act on bodily feelings like hunger, fullness, thirst, hot, cold, etc.) relate to eating behaviors in children ages 7-10 years. Findings will inform whether interventions targeting interoceptive awareness may be helpful for prevention of obesity and related chronic diseases.
Gender:
ALL
Ages:
7 years and above
Trial Updated:
11/05/2024
Locations: Pennsylvania State University, University Park, Pennsylvania
Conditions: Obesity, Childhood, Eating Behavior
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PDN Post Market, Multicenter, Prospective, Global Clinical Study
NCT05301816
Recruiting
The purpose of this post-market study is to evaluate the real-world experience of Nevro's Spinal Cord Stimulation (SCS) therapy in patients with chronic, intractable leg pain due to painful diabetic neuropathy (PDN). This is a multicenter, prospective, observational global study, that will partner diabetes management teams with pain physicians to provide an interdisciplinary treatment regimen for PDN patients. Outcomes will be assessed via standardized assessments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: WellSpan Interventional Pain Specialists, York, Pennsylvania
Conditions: Diabetic Neuropathy, Painful
Register for Updates
Customized TULSA-PRO Ablation Registry
NCT05001477
Recruiting
This patient registry will capture data from patients who have been or who are undergoing the transurethral ultrasound ablation (TULSA) procedure as part of their routine clinical care. The registry will shed light on real-world outcomes of safety and efficacy of the procedure and understand how a patient's quality of life is affected throughout their follow-up and lifetime.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Wellspan Health, York, Pennsylvania
Conditions: Prostate Cancer, Prostate Adenocarcinoma, Benign Prostatic Hyperplasia
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Tau PET Imaging in the NACC Study Cohort
NCT03189485
Recruiting
The purpose of this study is to measure the amount of a protein in the brain known as tau using an imaging procedure called Positron Emission Tomography (PET/CT). 18F-AV-1451 is a specialized radioactive PET imaging agent that is able to detect the presence of tau in the brain. In this study, the investigator will use the 18F-AV-1451 to capture images of tau in the brain. Findings from this study will likely provide insight into the mechanisms and distinctions of age-related cognitive decline an... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
11/05/2024
Locations: UPenn, Philadelphia, Pennsylvania
Conditions: Normal Controls, MCI
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