Pennsylvania is currently home to 3311 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Staying Healthy With Follow-up Care: A Mobile Chatbot Feasibility Study for AYA Cancer Survivors
NCT05863702
Recruiting
The purpose of this project is to identify effective strategies to assist survivors of childhood and young adult cancers (diagnosed between birth and age 39) who have not returned for follow-up cancer care for 3 or more years, to reengage with the health care system. The investigator will evaluate the effect of a novel, bidirectional conversational agent ("Penny"), compared to usual care, to assist patients with scheduling appointments, lab work as well as scans and specialty appointments as nee... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2024
Locations: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Survivorship
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Enhancing Prefrontal Oscillations and Working Memory in Early-course Schizophrenia
NCT05102929
Recruiting
This study will investigate the effects of intermittent Theta Burst Stimulation (iTBS) on natural oscillatory frequency of the dorsolateral prefrontal cortex (DLPFC) and working memory in early-course schizophrenia (EC-SCZ). Transcranial magnetic stimulation (TMS) will be used to evoke oscillatory activity, and EEG will record the responses of EC-SCZ participants. A working memory task will also be incorporated in order to determine how DLPFC natural frequency (NF) is related to working memory p... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/09/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Schizophrenia
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Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome
NCT00556530
Recruiting
22q11.2 deletion syndrome is a genetic disorder that can cause heart defects, facial abnormalities, and developmental and learning disabilities. The severity of the disorder can vary widely among people. This study will analyze DNA from people with 22q11.2 deletion syndrome to identify genetic variations that may affect the severity of the disorder.
Gender:
ALL
Ages:
All
Trial Updated:
07/09/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: DiGeorge Syndrome, 22q11.2 Deletion Syndrome
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Risk Factors That Increase the Chance of Developing Primary Graft Dysfunction After Lung Transplantation
NCT00552357
Recruiting
Primary graft dysfunction (PGD) is a severe lung complication that can occur in the days after lung transplant surgery. This study will analyze blood samples to determine if high levels of certain chemicals may increase the risk of developing PGD after a lung transplant.
Gender:
ALL
Ages:
Between 13 years and 68 years
Trial Updated:
07/09/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Primary Graft Dysfunction, Lung Transplantation
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Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiency
NCT06477159
Recruiting
This study aims to evaluate if a 6-month course of pancrelipase (CREON) treatment improves symptoms of exocrine pancreatic insufficiency (EPI) after an attack of acute pancreatitis. Diagnosis of EPI is measured by a fecal elastase value of \<200, and patients must have a qualifying symptom burden based on the EPI symptom tracker survey. Blood and stool will be analyzed as part of this study, and other surveys of health status will be used to track improvement of symptoms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Exocrine Pancreatic Insufficiency
Register for Updates
Early Intervention to Promote Cardiovascular Health of Mothers and Children
NCT06272045
Recruiting
Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) is a cluster randomized clinical trial, funded by the National Heart Lung \& Blood Institute. The study is designed to test the effectiveness of home visiting intervention to promote cardiovascular health and reduce disparities in maternal and early childhood cardiovascular health. Sites, in partnership with evidence-based home visiting programs, are recruiting 6400 participants in total (i.e., 3200 parent-dyads... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/08/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Cardiovascular Health
Register for Updates
Clinical Trial for Integrated Care to Help At Risk Teen (iCHART) Intervention
NCT05748730
Recruiting
This protocol will test the effectiveness of an intervention, iCHART (integrated Care to Help At-Risk Teens) and facilitate recruitment for other studies in the larger ETUDES Center grant, which are focused on treatment development for target risk factors for suicidal behavior, specifically, sleep, anhedonia, and stress related to cybervictimization. This study will recruit 900 adolescents which will be enrolled in a randomized controlled trial to test iCHART and will be randomized to iCHART or... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
07/08/2024
Locations: Children's Community Pediatrics (CCP- Waterdam) of Children's Hospital of Pittsburgh UPMC, McMurray, Pennsylvania
Conditions: Suicide and Depression, Adolescent Behavior
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Facilitating Access to Specialty Treatment
NCT05741411
Recruiting
The goal of this hybrid implementation-effectiveness study is to evaluate the effectiveness (hastened recovery times) and feasibility (fidelity in connecting to concussion specialty care) of a novel mobile health intervention, designed to reduce disparities in access to specialty care through the use of remote patient monitoring (RPM) to facilitate care hand-off from the emergency department (ED) to concussion specialty care. Participants will report their symptoms and activity once daily throug... Read More
Gender:
ALL
Ages:
Between 13 years and 18 years
Trial Updated:
07/08/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Mild Traumatic Brain Injury, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
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Frailty in Patients With Gastrointestinal Cancer Who Are Undergoing Major Surgery
NCT05694338
Recruiting
This research is for patients who have gastrointestinal cancer and have a planned major surgery. The purpose of this research is to identify cancer patients who may be at risk for frailty. Frailty is common in older adults and may include symptoms of weight loss, weakness, fatigue, low activity, slow walking and other illnesses. Frailty may increase the risk of problems after major surgery. The study will involve a survey, a blood sample, and a review of medical records.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2024
Locations: Robert Packer Hospital, Sayre, Pennsylvania
Conditions: Gastrointestinal Cancer
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Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial
NCT05655936
Recruiting
This is a single site, single-blinded parallel randomized control trial that investigates a multi-level intervention to improve postpartum blood pressure in women with hypertensive disorder pregnancy. The investigators will recruit women diagnosed with a hypertensive disorder of pregnancy, identified between 3rd trimester and 2 weeks post-delivery. The investigators will randomize participants to receive usual care home blood pressure monitoring for 6 weeks versus an intervention of usual care +... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/08/2024
Locations: Magee Women's Hospital of UPMC, Pittsburgh, Pennsylvania
Conditions: Preeclampsia, Hypertensive Disorder of Pregnancy, Toxemia, Pregnancy Complications, Hypertension, Pregnancy-Induced, Hypertension, Obesity, Overweight, Nutrition Disorders, Vascular Diseases, Cardiovascular Diseases, Pre-Eclampsia, Eclampsia, Gestational Hypertension
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A Study on Adding Precisely Targeted Radiation Therapy (Stereotactic Body Radiation Therapy) to the Usual Treatment Approach (Drug Therapy) in People With Breast Cancer
NCT05534438
Recruiting
The purpose of this study is to see if using Stereotactic Body Radiation Therapy/SBRT to treat a single metastatic site where cancer has worsened may be an effective treatment for people with oligometastatic breast cancer. Participants will stay on their usual drug therapy while they receive SBRT. This combination of SBRT to a single metastatic site and usual drug therapy may prevent participants' cancer from worsening in other metastatic sites or spreading.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2024
Locations: Lehigh Valley Health Network (Data Collection Only), Allentown, Pennsylvania
Conditions: Oligometastatic Breast Carcinoma, Breast Cancer, Metastatic Breast Cancer, Metastatic Breast Carcinoma, ER+ Breast Cancer, HER2+ Breast Cancer
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University of Pittsburgh Brain Health Initiative
NCT04708613
Recruiting
This project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehensive assessment of clinical, neuroimaging, and biomarker measures.
Gender:
MALE
Ages:
Between 29 years and 59 years
Trial Updated:
07/08/2024
Locations: University of Pittsburgh Department of Neurosurgery, Pittsburgh, Pennsylvania
Conditions: Traumatic Brain Injury
Register for Updates