Pennsylvania is currently home to 3301 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Open Versus Arthroscopic Stabilization of Shoulder Instability with Subcritical Bone Loss: the OASIS Trial
NCT04809064
Recruiting
This clinical trial will investigate the effects of three surgical procedures and the associated post-operative rehabilitation to optimize time to return to military duty, work and sports, and patient-reported physical function for military personnel and civilians with traumatic anterior shoulder instability and 10-20% glenoid bone loss.
Gender:
ALL
Ages:
Between 17 years and 50 years
Trial Updated:
10/08/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Shoulder Dislocation, Glenohumeral Dislocation, Anterior Shoulder Dislocation
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TumorGlow Intraoperative Molecular Imaging (IMI)
NCT04723810
Recruiting
This is a Phase 1/2 study in patients presenting with any solid tumor and/or diseased tissue even benign nodules presumed to be resectable and at risk for recurrence on pre-operative assessment who are considered to be good surgical candidates to evaluate the safety and efficacy of the image-guided surgery using indocyanine green for intramolecular imaging of solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/08/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Tumor, Solid
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Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior
NCT05572671
Recruiting
Most attempts to quit smoking end in relapse, or a return to regular smoking. One of the biggest threats to cessation is a lapse (i.e., any cigarette use during a quit attempt). Thus, characterizing why lapses occur is essential to understanding and preventing smoking relapse. Functional magnetic resonance imaging (fMRI) is a promising method for characterizing the psychological processes that lead to smoking lapses because it provides a way to measures patterns of brain activity thought to refl... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
10/07/2024
Locations: The Pennsylvania State University, University Park, Pennsylvania
Conditions: Smoking, Tobacco Use
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NMES for Achilles Tendon Rupture
NCT04727047
Recruiting
The majority of patients suffering an Achilles tendon rupture develop long term functional deficits in the affected leg. The goal of the proposed study is to evaluate a new rehabilitation protocol using Neuromuscular Electrical Stimulation (NMES) for reducing muscle atrophy and improving tendon properties. If proven beneficial, the proposed protocol can be easily adopted and incorporated as part of routine care for Achilles tendon rupture.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/07/2024
Locations: Penn State University, State College, Pennsylvania
Conditions: Achilles Tendon Rupture
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Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
NCT03295981
Recruiting
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania
Conditions: Giant Cell Tumor of Bone
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18F-Fluciclovine PET-MRI in High-grade Glioma
NCT05553041
Recruiting
The purpose of this study is to see if 18F-fluciclovine (Axumin®) PET imaging is useful and safe in the management of children with High Grade Gliomas. Investigators seek to determine if this imaging will help doctors tell the difference between tumor growth (progression) and other tumor changes that can occur after treatment.
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
10/04/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Glioma, High Grade Glioma, Glioma, Malignant, Glioma Intracranial, Diffuse Glioma
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A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
NCT05926765
Recruiting
This study will assess the efficacy and safety of bilateral intra-parotid administration of AAV2-hAQP1 in adults with Grade 2 or Grade 3 radiation-induced late xerostomia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: Penn State, Hershey, Pennsylvania
Conditions: Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
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C-TIL051 in Non-Small Cell Lung Cancer
NCT05676749
Recruiting
The goal of this Phase 1 clinical study is test tumor infiltrating lymphocytes (known as C-TIL051) with NKTR-255 and anti-PD1 therapy for subjects with refractory non-small cell lung cancer. The purpose of this study is to: 1. Test the safety and ability for subjects to tolerate the TIL therapy 2. Measure to see how the NSCLC responds to the TIL therapy Participants will be asked to: * Provide a tumor sample prior to the start of any treatment which will be used to make the C-TIL051. * Recei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: Allegheny Health Network-West Penn Hospital, Pittsburgh, Pennsylvania
Conditions: Metastatic Non Small Cell Lung Cancer
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Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section
NCT05380531
Recruiting
The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: UPMC Magee Women's Hospital, Pittsburgh, Pennsylvania
Conditions: Cesarean Section Complications, Opioid Use
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Childhood Cancer Predisposition Study (CCPS)
NCT04511806
Recruiting
The Childhood Cancer Predisposition Study (CCPS) is a multi-center, longitudinal, observational study that will collect clinical and biological data and specimens from children with a cancer predisposition syndromes (CPS) and their relatives. The central hypothesis is that studying individuals at high risk for childhood cancer creates a unique opportunity for improving the understanding of carcinogenesis, tumor surveillance, early detection, and cancer prevention, which will collectively contri... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/03/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Pediatric Cancer
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Predicting Concussion Outcomes with Salivary MiRNA
NCT02901821
Recruiting
The purpose of this study is to identify changes in salivary ribosomal nucleic acid (RNA) expression that are predictive of symptom duration and character following mild traumatic brain injury (mTBI) in children.
Gender:
ALL
Ages:
Between 5 years and 21 years
Trial Updated:
10/03/2024
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Concussion, Mild
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Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
NCT02434393
Recruiting
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. From the originally enrolled participants, the continuation of the ADNI-D study will enroll 120 participants which will include following participants from the original (parent) protocol and enrollment of... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
10/03/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Major Depression, Late Life Depression (LLD)
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