Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
NEUROCUPLE™ in TKA Patients to Enhance Pain Management
NCT06460350
Recruiting
This is a randomized (1:1) placebo-controlled clinical trial to determine the feasibility and effectiveness of 30-day application of NEUROCUPLE™ patch for pain reduction and opioid consumption following TKA. Results will establish NEUROCUPLE™ as an effective non-opioid postoperative pain management device for FDA approval. Importantly, we have a placebo device (device without the captor array layer) that looks exactly like the active device, allowing us to conduct a true placebo randomized study... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/21/2024
Locations: UPMC Shadyside Hospital, Pittsburgh, Pennsylvania
Conditions: Total Knee Arthroplasty
Register for Updates
Cerebrovascular Health and Resilience in Midlife
NCT06029348
Recruiting
This study examines cardiovascular responses to a brief psychological challenge under laboratory conditions among adult volunteers. The study volunteers are asked to complete two study sessions. In one session, the volunteers are asked to provide demographic and health-related information via questionnaires and an interview. In that session, volunteers would then be asked to undergo evaluations of their body composition, blood pressure, heart rate, and other signs of cardiovascular function and... Read More
Gender:
ALL
Ages:
Between 40 years and 59 years
Trial Updated:
10/21/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Psychological Stress, Cardiovascular Diseases, Cerebrovascular Disorders
Register for Updates
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
NCT02901184
Recruiting
Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will not be studied by industry. SPIRRIT is a unique Registry-Randomized Clinical Trial (RRCT) that will test the hypothesis that spironolactone plus standard of care compared to standard of care alone reduc... Read More
Gender:
ALL
Ages:
Between 50 years and 99 years
Trial Updated:
10/21/2024
Locations: Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
Conditions: Heart Failure With Preserved Ejection Fraction
Register for Updates
Connected Through Coaching for Flourishing Families
NCT06145451
Recruiting
Despite the known association between the quality of participant relational engagement with service providers and clinical outcomes, limited studies have examined caregiver Relational Responsiveness (RR) as a mechanism to achieve maltreatment prevention program outcomes. Using a realist-informed mixed method approach, this study will examine RR's role in mediating the effects of a community-based maltreatment prevention program, the Family Success Network (FSN) on protective factors against malt... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Maltreatment by Parent
Register for Updates
Fear of Recurrence and Stopping Immunotherapy
NCT04761328
Recruiting
The study includes participants experiencing distress with regard to stopping immunotherapy and will utilize cognitive-behavioral therapy to reduce fear of recurrence, depression, and anxiety and improve quality of life.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/18/2024
Locations: UPMC Hillman Cancer Centers, Pittsburgh, Pennsylvania
Conditions: Cognitive Behavioral Therapy
Register for Updates
A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation
NCT06234969
Recruiting
This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD). The investigators will demonstrate that IPS cTBS results in significant reduction in arousal (measured by startle response) compared to sham cTBS, that IPS cTBS interacts with extinction training to further improve arousal, and that there is a dose/response effect of cTBS on arou... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
10/17/2024
Locations: Center for the Treatment and Study of Anxiety, University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Posttraumatic Stress Disorder
Register for Updates
Anti-inflammatory Drugs and Serum Prostate-Specific Antigen Test
NCT05629494
Recruiting
Prostate cancer is the most frequently diagnosed cancer in men in the Unites States. Nearly 1 million prostate biopsy procedures are performed in the United States annually and elevated prostate-specific antigen (PSA) level is the primary reason for prostate biopsy in \> 90% of cases. However, at the PSA levels which trigger prostate biopsy, often no cancer is found in prostate biopsy specimens. PSA test can be elevated due to reasons other than cancer such as inflammation or natural variation i... Read More
Gender:
MALE
Ages:
Between 18 years and 80 years
Trial Updated:
10/17/2024
Locations: Penn State-Hershey Medical Center, Hershey, Pennsylvania
Conditions: Prostate Cancer, Prostate Inflammation, PSA
Register for Updates
Audio-based Mental Health Intervention Study
NCT05555745
Recruiting
This is a study on an audio-based digital intervention designed to reduce symptoms of depression. Participants who experience at least moderate symptoms of depression will be invited to participate in the study. Participants will be randomly assigned to receive one of two audio-based digital interventions. The experimental intervention based on behavioral activation treatment for depression. The control intervention is based on self-monitoring. Depression symptoms and related mental health sympt... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/17/2024
Locations: The Pennsylvania State University, University Park, Pennsylvania
Conditions: Depressive Symptoms
Register for Updates
Single and Multiple Ascending Dose Study in Healthy Participants and Participants With an Autoimmune Disease
NCT06488209
Recruiting
The main purpose of this study is to to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity of LAD191 in healthy adults and in adults with an autoimmune disease.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/16/2024
Locations: Jennifer Parish, MD, Philadelphia, Pennsylvania
Conditions: Healthy Volunteers, Autoimmune Disease
Register for Updates
Biennial CEM in Women with a Personal History of Breast Cancer
NCT06105749
Recruiting
This is a prospective clinical trial that will examine if biennial contrast-enhanced mammography added to annual 3D mammography (tomosynthesis) substantially improves breast cancer detection with minimal increase in false-positives, in women with a personal history of breast cancer.
Gender:
FEMALE
Ages:
Between 30 years and 79 years
Trial Updated:
10/16/2024
Locations: UPMC Magee-Womens Imaging - Bethel Park, Bethel Park, Pennsylvania
Conditions: Breast Cancer, Breast Neoplasms, Breast Cancer Female, Neoplasms
Register for Updates
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)
NCT05329649
Recruiting
This is a single-dose, open-label study in pediatric participants with severe SCD and hydroxyurea (HU) failure or intolerance. The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells (hHSPCs) (CTX001).
Gender:
ALL
Ages:
Between 2 years and 11 years
Trial Updated:
10/16/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Sickle Cell Disease, Hydroxyurea Failure, Hydroxyurea Intolerance, Hemoglobinopathies, Hematological Diseases
Register for Updates
Exercise-based Program for Rehabilitation of Veterans With Severe Mental Illness
NCT05157620
Recruiting
This is a hybrid1, effectiveness-implementation study of yoga-based exercises (YE) as an adjunctive tool for rehabilitation among persons with Severe Mental Illness (SMI). The two-arm randomized controlled trial will compare the efficacy of YE compared to the Wellness Lifestyle Program (WLP). Primary outcomes of the study will be self-report and performance-based measures of community functioning, defined in the investigators study as social, leisure, employment, and life skills functioning in t... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/16/2024
Locations: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania
Conditions: Schizophrenia, Schizoaffective, Bipolar Disorder 1
Register for Updates