Pennsylvania is currently home to 3305 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The HOME Program for Individuals With Traumatic Brain Injury and Family Members
NCT05117619
Recruiting
This purpose of this study is to evaluate an innovative rehabilitation intervention for persons with chronic TBI-related symptoms (1 year or more post injury) and their families. The primary study aims are to 1) test the intervention's effects on patients' community reintegration, quality of life, and ability to manage self-identified TBI problems at the completion of the intervention and 2) test the intervention's effects on family caregivers' depressive symptoms, burden, and met family needs a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/30/2024
Locations: Villanova University, Villanova, Pennsylvania
Conditions: Brain Injuries, Traumatic
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Treatment of Refractory BK Infections With Related Donor BK Specific Cytotoxic T-cells (CTLs)
NCT04197596
Recruiting
BK cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be safe and effective in decreasing specific viral load in children, adolescents and young adults (CAYA) with refractory BK infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) or with primary immunodeficiencies (PID).
Gender:
ALL
Ages:
Between 1 month and 79 years
Trial Updated:
05/30/2024
Locations: Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Viral Infection, Primary Immune Deficiency Disorder
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Wearable Wireless Respiratory Monitoring System That Detects and Predicts Opioid Induced Respiratory Depression
NCT06442488
Recruiting
An observational study will be conducted in approximately 14 participants to evaluate the ability of a wearable, wireless acoustic Respiratory Monitoring System (RMS) to accurately measure a participant's respiratory rate, tidal volume, minute ventilation, and duration of apnea in a noisy environment. Sensor accuracy will be measured with adaptive filtering and active noise cancellation turned on versus turned off.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/29/2024
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Respiratory Insufficiency, Clinical Deterioration
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DISE: Phenotyping Obstruction Patterns
NCT05050383
Recruiting
Drug-induced sleep endoscopy (DISE) represents an opportunity to evaluate the upper airway in sleep-like conditions. In its current clinical form, however, DISE does not routinely determine the functional impact of anatomic and neuromuscular factors on airflow obstruction. The investigators will apply nasal pressure (CPAP) during DISE to generate pressure-flow and pressure-area relationships, deriving functional determinants of upper airway obstruction during sleep. In addition, they will use o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/29/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Obstructive Sleep Apnea
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Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults With Relapsed/Refractory Acute Myeloid Leukemia
NCT03971799
Recruiting
This phase 1/2 trial aims to determine the safety and feasibility of antiCD33 chimeric antigen receptor (CAR) expressing T cells (CD33CART) in children and adolescents/young adults (AYAs) with relapsed/refractory acute myeloid leukemia (AML). The trial will be done in two phases: Phase 1 will determine the maximum tolerated dose of CD33CART cells using a 3+3 trial design, with dose-escalation for autologous products separated from dose-escalation for an allogeneic arm. Phase 2 is an expansion ph... Read More
Gender:
ALL
Ages:
Between 1 year and 35 years
Trial Updated:
05/29/2024
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Acute Myelogenous Leukemia
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Genomic Risk in Retroperitoneal Sarcoma
NCT06436846
Recruiting
The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease. Often, tumors recur in locations within the retroperitoneum remote from the original primary tumor. This study hypothesizes that normal appearing retroperitoneal fat actually harbors underlying genetic changes which predispose to development of future liposarcoma. To accomplish this goal, retroperitoneal fat is sampled... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/28/2024
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Retroperitoneal Liposarcoma, Soft Tissue Sarcoma
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iLookOut Micro-learning to Improve Knowledge Retention
NCT06273618
Recruiting
This project investigates whether a multi-faceted strategy involving iLookOut's evidence-based Core Training plus an innovative follow-up Micro-Learning can promote knowledge retention and change behavior among early childhood professionals (ECPs) with regard to child abuse and its reporting. Additionally, this study will evaluate if non-ECPs experience similar improvements and retention of knowledge and changes in behavior as do ECPs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/28/2024
Locations: Penn State College of Medicine, Hershey, Pennsylvania
Conditions: Knowledge, Attitudes, Practice
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Parkinson's Foundation PD GENEration Genetic Registry
NCT04994015
Recruiting
Development of a central repository for PD-related genomic data for future research.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/28/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Parkinson's Disease
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Hydrus® Microstent New Enrollment Post-Approval Study
NCT04553523
Recruiting
The purpose of this post-approval study is to evaluate the rate of Hydrus Microstent malposition and associated clinical sequelae occurring within 24 months post-operation. Qualified subjects will undergo uncomplicated cataract surgery with placement of a monofocal intraocular lens (IOL), followed by implantation of the Hydrus Microstent.
Gender:
ALL
Ages:
45 years and above
Trial Updated:
05/28/2024
Locations: Scott & Christie and Associates, PC, Cranberry Township, Pennsylvania
Conditions: Primary Open Angle Glaucoma
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Comparing Two Different Emotion Therapies for Autistic Youth and Young Adults
NCT06158581
Recruiting
Too few clinicians are able and willing to help autistic patients. A recent review identified challenges to mental health service delivery in autism, including a lack of interventions designed for community implementation and limited workforce capacity. It has been argued that improving impairment in emotion regulation has the potential to improve a range of mental health difficulties in autistic people. In this clinical trial, the investigators are comparing two evidence-based interventions for... Read More
Gender:
ALL
Ages:
Between 12 years and 25 years
Trial Updated:
05/24/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Autism Spectrum Disorder
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RH Genotype Matched RBC Transfusions
NCT04156893
Recruiting
To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.
Gender:
ALL
Ages:
6 months and above
Trial Updated:
05/24/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Sickle Cells Disease
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Abbott DBS Post-Market Study of Outcomes for Indications Over Time
NCT04071847
Recruiting
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.
Gender:
ALL
Ages:
All
Trial Updated:
05/24/2024
Locations: Center for Interventional Pain & Spine, Exton, Pennsylvania
Conditions: Movement Disorders, Parkinson Disease, Essential Tremor, Tremor, Dystonia, Primary Dystonia, Secondary Dystonia
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