Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
NCT02592291
Recruiting
This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain Injury) to improve their wellness and self-management skills compared to those who receive standard of care only.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
09/13/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Spinal Cord Injuries, Cerebral Palsy, Spinal Dysraphism, Brain Injuries, Spina Bifida, Traumatic Brain Injury
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AMBU Bag Manual Ventilation Vs. Transport Ventilator Mechanical Ventilation for Transport
NCT06006208
Recruiting
This is a clinical trial to compare the oxygenation and ventilation performance between manual ventilation and mechanical ventilation when transporting cardiac patients to the ICU.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2024
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Oxygenation, Manual Ventilation, Mechanical Ventilation, Point of Care Ultrasound, Cardiac Function Disturbance Postoperative
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Acoustic Stimulation, Sleep, and Cognitive-Emotional Processes in Young Adults with Anxiety and Depression Symptoms
NCT05802004
Recruiting
In this study, the investigators will recruit young adults (ages 18-25 years) with elevated anxiety/depression symptoms and sleep disturbance. Participants will complete two overnights in a sleep lab. During one of the overnights, slow-wave activity will be enhanced by delivering sub-arousal auditory tones during slow-wave sleep using a headband device (Philips SmartSleep or Dreem 2). During the other overnight, tones will not be administered. Cognitive and emotional processes will be evaluated... Read More
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
09/12/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Acoustic Stimulation
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Improving Measurement and Treatment of Post-stroke Neglect
NCT03317860
Recruiting
This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial direct current stimulation) for individuals with neglect. This study will also determine whether items from various neglect assessments can be combined to establish a more comprehensive neglect measure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2024
Locations: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania
Conditions: Stroke
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Postpartum Care in the NICU (PeliCaN) Transitions
NCT06521398
Recruiting
This is a randomized controlled trial of a dyad-centered, doula support and healthcare coordination model of care in a large urban neonatal intensive care unit (NICU), which serves a high-risk, low-income, majority Black population. In addition to doula support and coordination of care in the NICU, there will be a warm handoff to a community doula to continue the support once infants leave the Hospital of the University of Pennsylvania (HUP) NICU.
Gender:
FEMALE
Ages:
16 years and above
Trial Updated:
09/11/2024
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Stress Disorders, Post-Traumatic, Premature Birth, Postpartum Depression, Postpartum Anxiety
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Acoustic Waveform Respiratory Evaluation
NCT06512064
Recruiting
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
Gender:
ALL
Ages:
Between 8 years and 65 years
Trial Updated:
09/11/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders, Bronchiectasis, Airway Malacia, Healthy Control
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Promising ROd-cone DYstrophy Gene TherapY
NCT05748873
Recruiting
This is a two-step, multicenter, Phase I/II study including an open-label dose-escalation phase (Step 1) and a three-arm, controlled, double-masked, randomized extension phase (Step 2), in subjects with advanced RCD due to a mutation in the RHO, PDE6A, or PDE6B gene.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/11/2024
Locations: UPMC Eye Center, Pittsburgh, Pennsylvania
Conditions: Retinitis Pigmentosa
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International CDKL5 Registry
NCT04486768
Recruiting
Owing to the recent classification of CDKL5 Deficiency Disorder (CDD) as a unique disorder, there is a limited understanding of overall disease natural history and meaningful outcome measures. An international patient registry aimed at collecting both patient/caregiver and clinician-entered demographic, patient-reported outcome (PRO) and treatment data would benefit both the scientific and patient communities. This CDD registry will follow up to 500 patients diagnosed with CDD over several years... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/10/2024
Locations: University of Pennsylvania Orphan Disease Center, Philadelphia, Pennsylvania
Conditions: CDKL5 Deficiency Disorder (CDD)
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Pilot Trial of the RUBI Program for Autistic Adults
NCT06593613
Recruiting
The goal of this clinical trial is to evaluate if a redesigned version of the RUBI parenting intervention can reduce challenging behaviors and improve adaptive skills in autistic adults with co-occurring challenging behaviors. The main questions it aims to answer are: * Is the redesigned RUBI intervention feasible and acceptable for autistic adults and their families? * Does the redesigned RUBI intervention reduce challenging behaviors and enhance the quality of life for autistic adults? * Rese... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: A.J. Drexel Autism Institute, Philadelphia, Pennsylvania
Conditions: Autism Spectrum Disorder, Behavior, Parenting
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Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial Hypertension
NCT06543745
Recruiting
The purpose of the study is to learn more about how low-resistance training impacts frailty and the quality of life of people with pulmonary arterial hypertension (PAH). Low-resistance training is an evidence-based approach that may help patients improve their functional ability.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: University of Pennsyvania, Philadelphia, Pennsylvania
Conditions: Pulmonary Arterial Hypertension, Frailty
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First In Human Study of CX-801 in Advanced Solid Tumors
NCT06462794
Recruiting
The purpose of this first-in-human study, CTMX-801-101, is to characterize the safety, tolerability, and antitumor activity of CX-801 as monotherapy and in combination with pembrolizumab in adult participants with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: University of Pittsburgh Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Solid Tumor, Adult
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A Trial of Post-Discharge Transitional Care for Patients With Chronic Liver Disease
NCT05733832
Recruiting
Patients with complications of advanced liver disease often have difficulties after hospital discharge that result in early hospital readmission. Poor outcomes for these patients during this transitional time could be improved through the use of innovative transitional care models. This proposal aims to examine the effect of a transitional care model, The Transitional Liver Clinic (TLC), in reducing hospital re-admissions, improving quality of life, and improving patient experience.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/05/2024
Locations: Albert Einstein Healthcare Network, Philadelphia, Pennsylvania
Conditions: Liver Diseases
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