Pennsylvania is currently home to 3305 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Prospective Database of Infants With Cholestasis
Recruiting
Biliary atresia, idiopathic neonatal hepatitis, and specific genetic cholestatic conditions are the most common causes of jaundice and hyperbilirubinemia that continue beyond the newborn period. The long term goal of the Childhood Liver Disease Research Network (ChiLDReN) is to establish a database of clinical information and plasma, serum, and tissue samples from cholestatic children to facilitate research and to perform clinical, epidemiological and therapeutic trials in these important pediat... Read More
Gender:
ALL
Ages:
6 months and below
Trial Updated:
06/04/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Biliary Atresia, Neonatal Cholestasis
Synovial Sarcoma Registry / Biospecimen Repository
Recruiting
The purpose of this study is to collect and store data and samples for future research to attempt to improve outcomes for patients with synovial sarcoma. The future research will involve various types of genetic testing. Participants will be asked to allow access to medical records and leftover tumor tissue and may be asked to give a blood or saliva sample. Participants will also be asked to completed questionnaires about their medical history and may be contacted every 6 to 12 months for updat... Read More
Gender:
ALL
Ages:
All
Trial Updated:
06/03/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Synovial Sarcoma
Eliminating Monitor Overuse Trial (EMO Trial)
Recruiting
The purpose of this study is to identify the optimal deimplementation strategies for an overused practice: continuous pulse oximetry monitoring of children hospitalized with bronchiolitis who are not receiving supplemental oxygen.
Gender:
ALL
Ages:
2 months and above
Trial Updated:
06/03/2024
Locations: Penn State Hershey Children's Hospital, Hershey, Pennsylvania
Conditions: Bronchiolitis Acute Viral
PET Imaging of Vaso-Occlusive Crisis (VOC) in SCD
Recruiting
The purpose of this study is to find objective biomarkers of vaso-occlusion (blood vessel blockage) in people with SCD. Using information from earlier studies and work being done, researchers have developed a strategy to image VOC, using positron emission tomography (PET). The ability to see and measure VOC in SCD patients can help patient care, by showing when and how a VOC is occurring or going to occur. Studying this method will also help in future drug research, as it will allow researchers... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/03/2024
Locations: UPMC, Pittsburgh, Pennsylvania
Conditions: Sickle Cell Disease
Systemic Hypothermia in Acute Cervical Spinal Cord Injury
Recruiting
This study is a prospective multi-center trial designed to determine the safety profile and efficacy of modest (33ºC) intravascular hypothermia following acute cervical (C1 to C8) Spinal Cord Injury (SCI).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/03/2024
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Spinal Cord Injury, Acute
One-Time DNA Study for Vasculitis
Recruiting
The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.
Gender:
ALL
Ages:
7 years and above
Trial Updated:
06/03/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Giant Cell Arteritis, Granulomatosis With Polyangiitis (Wegener's), Microscopic Polyangiitis, Polyarteritis Nodosa, Takayasu's Arteritis
A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas
Recruiting
The goal of this clinical trial is to assesses the safety of autologous RD2 Ver.02 as compared to a control for managing transsphincteric and intersphinsteric anal fistulas. The main questions it aims to answer are: Assess the safety and efficacy of RD2 Ver.02 in anal fistula application, compared to control. Complication rate by 6 months of anal fistula treatment with RD2 Ver.02 compared to control. Recurrence of anal fistula at 12 months post-treatment Incidence of perirectal infection by... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2024
Locations: Allegheny Health Network, Pittsburgh, Pennsylvania
Conditions: Anal Fistula
Cardiovascular Effects of a Healthy Dietary Pattern Containing Eggs
Recruiting
This study will examine the effect of a healthy diet containing 2 eggs per day compared to a healthy diet containing 3 eggs per week on biomarkers of heart health after 4 weeks.
Gender:
ALL
Ages:
Between 30 years and 60 years
Trial Updated:
05/31/2024
Locations: The Pennylvania State University, University Park, Pennsylvania
Conditions: Cardiovascular Diseases
PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
Recruiting
A prospective, single-arm, multi-center study designed to gather additional information on the LimFlow System.
Gender:
ALL
Ages:
Between 18 years and 95 years
Trial Updated:
05/31/2024
Locations: Penn State Health, Hershey, Pennsylvania
Conditions: Critical Limb Ischemia, Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia
Remote Pregnancy Monitoring to Improve Access
Recruiting
The goal of this clinical trial is to determine the effectiveness of remote nonstress test (NST) compared to in-clinic NSTs in improving fetal testing completion rates. Participants will be randomized to either in-clinic NSTs or use of an FDA-approved remote monitoring belt for their pregnancy monitoring.
Gender:
FEMALE
Ages:
All
Trial Updated:
05/30/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Fetal Monitoring
A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications
Recruiting
This registry is a prospective, multicenter, international, single arm, observational post-approval registry with follow-up at 3, 6, and 12 months, and annually for 5 years. The proposed registry will enroll 60 subjects and will be conducted at approximately 10 centers worldwide.
Gender:
ALL
Ages:
Between 30 years and 99 years
Trial Updated:
05/30/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Movement Disorders, Neurology, Parkinsons Disease
Insomnia Behavioral Intervention Study
Recruiting
This randomized pilot study (n=20) explores the effects of a behavioral intervention, that includes sleep hygiene improvements, in long-term users of sleeping pills, aiming to alleviate or stabilize symptoms of insomnia, monitor and decrease sleeping pill usage. Adherence will be monitored by an optional smartphone application.
Gender:
ALL
Ages:
Between 55 years and 85 years
Trial Updated:
05/30/2024
Locations: University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Conditions: Chronic Insomnia