Pennsylvania is currently home to 3305 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Perioperative Glucocorticoid Administration in the Treatment of Adult Distal Radius Fractures
NCT03898154
Recruiting
The purpose of this investigation is to compare functional outcome measures and range of motion for patients receiving glucocorticoid (GC) injections versus those not receiving GCs for the treatment of distal radius fractures. The investigators hypothesize that patients who receive GC will have improved ROM and functional outcome measures compared to patients who do not receive GC. In addition, this study aims to determine if there is a difference in rates of complications and postoperative pain... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Geisinger Woodbine, Danville, Pennsylvania
Conditions: Distal Radius Fracture
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Plantar Fasciitis Randomized Clinical Control Trial
NCT03231150
Recruiting
The primary aim of this clinical experiment is to compare, in terms of pain relief measured using the 10-cm visual analog scale (VAS) pain score (5-7), the clinical results of ultrasound-guided injection (USGI) versus anatomic topography-guided injection (ATGI) of corticosteroid for the treatment of proximal PF. Secondary aims will be to compare foot-related quality of life, as measured using the Foot Function Index (FFI)and the Bristol Foot Score (BFS), between the injection groups, and also to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Penn Presbyterian Medical Center, Philadelphia, Pennsylvania
Conditions: Plantar Fascitis
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Connect® Myeloid Disease Registry
NCT01688011
Recruiting
The purpose of the Connect® Myeloid disease registry is to provide unique insights into treatment decisions and treatment patterns as they relate to clinical outcomes of patients with myeloid diseases in routine clinical practice. This disease registry will also evaluate molecular and cellular markers that may provide further prognostic classification which may or may not be predictive of therapy and clinical outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Consultants in Medical Oncology and Hematology, Drexel Hill, Pennsylvania
Conditions: Myelodysplastic Syndromes, Primary Myelofibrosis, Leukemia, Myeloid, Acute
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Neuroinflammation Imaging in AD
NCT04274998
Recruiting
This research study is being done to learn more about inflammation in the brain using Positron Emission Tomography/Computed Tomography (PET/CT) imaging in people with Alzheimer's Disease/Mild Cognitive Impairment or healthy controls. If the subject agrees to be in this study, she/ he will have a PET/CT scan using the investigational radiotracer \[18F\]NOS. A subject with a specific genetic polymorphism may also agree to be in the sub-study in which she/he will have another PET/CT scan using the... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
04/29/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Alzheimer Disease, Healthy Volunteer
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Positive Parenting Program in Foster Care
NCT03910491
Recruiting
The purpose of the study is to evaluate early implementation outcomes of a positive parenting program, Child Adult Relationship Enhancement in Primary Care (PriCARE), in the foster care setting and to assess the efficacy of PriCARE in promoting positive parenting and increasing empathy among foster caregivers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Child Behavior Problem, Child Behavior Disorders, Parenting
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Geisinger Antibiotic Allergy Pilot Program: Assess and Address
NCT05464615
Recruiting
This is a prospective non-inferiority study to evaluate penicillin allergy history in patients with reported penicillin allergy, who require penicillin or penicillin-derivative antibiotic during inpatient admission using a focused questionnaire. A simplified scoring system will be assigned to patient responses, and the total score will be utilized to identify low-risk patients that have a minimal risk of allergic reactions on exposure to penicillin or its derivative. Patients determined to have... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/28/2024
Locations: Geisinger Medical Center, Danville, Pennsylvania
Conditions: Penicillin Allergy
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A Study of RGLS8429 in Patients With Autosomal Dominant Polycystic Kidney Disease
NCT05521191
Recruiting
Primary Objectives * To assess the safety and tolerability of RGLS8429 * To assess the impact of RGLS8429 on ADPKD biomarkers Secondary Objectives * To assess the impact of RGLS8429 on height-adjusted total kidney volume (htTKV) * To characterize the pharmacokinetic (PK) properties of RGLS8429 * To assess the impact of RGLS8429 on renal function
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/27/2024
Locations: Northeast Clinical Research Center, Bethlehem, Pennsylvania
Conditions: Autosomal Dominant Polycystic Kidney Disease, ADPKD, Polycystic Kidney, Autosomal Dominant
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Is Sensorimotor Training Effective Following a Distal Radius Fracture?
NCT06299228
Recruiting
The purpose of this study is to compare the short-term outcomes of individuals who have surgery (volar plate) for a wrist (distal radius) fracture who have routine hand therapy treatment versus routine hand therapy treatment and sensorimotor activities. Individuals who meet inclusion criteria at the facilities collecting data will be invited to participate. If they agree to participate, they will randomly and blindly (via concealed envelopes) be assigned to the control (routine treatment) or the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/26/2024
Locations: Hand Surgery Associates, Olyphant, Pennsylvania
Conditions: Distal Radius Fractures
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Genetic and Epigenetic Basis of Chronic Wounds
NCT03793062
Recruiting
This pilot study is designed for chronic wounds that fail to heal in a timely manner carry specific genetic signatures. These genetic signatures will be studied using debrided wound tissue that is removed by the wound care provider as part of standard of care. The reference genomic signature will be evaluated by obtaining blood samples and will be compared with wound debrided tissue genomic signature to understand wound specific genomic changes.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/26/2024
Locations: UPMC Wound Care Centers, Pittsburgh, Pennsylvania
Conditions: Chronic Wounds
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Sweet Scents to Sweet Dreams
NCT06247696
Recruiting
The purpose of this study is to determine the effect of herbal pillows on sleep and quality of life in a healthy population using actigraphy, validated questionnaires and daily diary logs. The goal of this study is to improve sleep and quality of life using herbal and Ayurveda/holistic-based botanical pillows.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2024
Locations: Duquesne University, Pittsburgh, Pennsylvania
Conditions: Sleep Disturbance, Mental Health Issue
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A First-in-human Study of PRTH-101 Monotherapy +/- Pembrolizumab in Subjects With Advanced Malignancies
NCT05753722
Recruiting
The goal of this Open-Label Study is to evaluate the safety and tolerability of PRTH-101 alone or in combination with pembrolizumab in adults with advance or metastatic solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2024
Locations: University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Advanced or Metastatic Solid Tumors
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[Lu-177]Ludotadipep in Castration-resistant Prostate Cancer(CRPC): Investigation of Drug and Application
NCT05458544
Recruiting
Phase 1: The objective of the Phase 1 part of the clinical trial is to verify safety and tolerability (dose-limiting toxicity \[DLT\], maximum tolerated dose \[MTD\]) of a single 3.7 Giga-Becquerel (GBq) dose with the potential for one dose level de-escalation to 2.775 GBq if necessary, to determine the recommended \[177Lu\]Ludotadipep dose for use in the Phase 2a part of the trial. Phase 2a: The objective of the Phase 2a part of the trial is to evaluate safety and efficacy for repeated adminis... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
04/25/2024
Locations: Pennsylvania Cancer Specialists & Research Institute (Formerly Gettysburg Cancer Center), Gettysburg, Pennsylvania
Conditions: Metastatic Castration-resistant Prostate Cancer
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