Pennsylvania is currently home to 3305 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Providing Oxygen During Intubation in the NICU Trial
Recruiting
Tracheal intubation in the NICU is frequently complicated by severe oxygen desaturation. Apneic oxygenation, a method of applying free flowing oxygen via nasal cannula to apneic patients undergoing intubation, prevents or delays oxygen desaturation during intubation in adults and older children. We propose to enroll patients at two sites (Hospital of the University of Pennsylvania and Children's Hospital of Philadelphia) in a randomized trial in infants undergoing intubation in the NICU to deter... Read More
Gender:
ALL
Ages:
Between 0 days and 365 days
Trial Updated:
04/25/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Neonatal Respiratory Failure, Tracheal Intubation Morbidity
Longitudinal Study for Eosinophilic Granulomatosis With Polyangiitis
Recruiting
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare immune system disorder that causes asthma, an excessive number of eosinophils (a type of white blood cell) in the blood, and the inflammation of blood vessels, or vasculitis. In order to properly treat EGPA, it is critical that the level of disease activity can be determined over the course of the disease. The purpose of this study is to determine new biological markers, or biomarkers, that may be used to assess the severity of this... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/25/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Eosinophilic Granulomatosis With Polyangiitis, Churg-Strauss Syndrome
Study of Intravenous Amisulpride for Prophylaxis of Post-operative Nausea and Vomiting (PONV) in Pediatric Patients
Recruiting
Randomized, double-blind, pediatric trial of amisulpride for prophylaxis of post operative nausea and vomiting
Gender:
ALL
Ages:
Between 2 months and 17 years
Trial Updated:
04/24/2024
Locations: The Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania
Conditions: Nausea and Vomiting, Postoperative
Open Label Trial of Oral Letermovir for CMV Prophylaxis in Thoracic Transplant Recipients
Recruiting
Open label study to determine tolerability and efficacy of letermovir for CMV prophylaxis in heart and lung transplant recipients and compare it to the efficacy of valganciclovir historical controls. The study hypotheses are: 1. Letermovir prophylaxis will be associated with similar rates of CMV infection as valganciclovir among heart and lung transplant recipients 2. Letermovir will be better tolerated than valganciclovir for CMV prophylaxis in heart and lung transplant recipients, with a high... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: Penn Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Cytomegalovirus Infections, Transplant-Related Disorder
Improving Rehabilitation for Veterans After Total Knee Arthroplasty Using Individualized Recovery Trajectories
Recruiting
This study will examine the impact of a new clinical decision support tool for rehabilitation after total knee arthroplasty (TKA). Typically, TKA rehabilitation is generic with most patients receiving the same dosage and contents of rehabilitation despite notable diversity among patients who undergo TKA. The investigators clinical support decision tool is designed to help physical therapists tailor rehabilitation treatments and dosages to the individual needs, goals, and preferences of Veterans... Read More
Gender:
ALL
Ages:
Between 40 years and 90 years
Trial Updated:
04/23/2024
Locations: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania
Conditions: Total Knee Arthroplasty
Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer
Recruiting
The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resections of colorectal cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania
Conditions: Colorectal Neoplasms
A Study to Find and Confirm the Dose and Assess Safety, Reactogenicity and Immune Response of a Vaccine Against Pandemic H5N1 Influenza Virus in Healthy Younger and Older Adults
Recruiting
The aim of this study is to evaluate the safety, reactogenicity and immunogenicity of the Flu Pandemic messenger RNA (mRNA) vaccine (including dose-finding and dose-confirmation) administered healthy adults 18 to 85 years of age.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/19/2024
Locations: GSK Investigational Site, Philadelphia, Pennsylvania
Conditions: Influenza, Human
Head to Head Comparison of Upper Airway Stimulation and Continuous Positive Airway Pressure; a Pilot Study.
Recruiting
To date, there has been no head to head comparison of Upper Airway Stimulation (UAS) and Continuous Positive Airway Pressure (CPAP) utilizing a full night polysomnographic evaluation. With this study we aim to evaluate a pilot cohort of patients with OSA treated with CPAP or UAS using the WatchPAT polysomnography system.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
04/19/2024
Locations: Thomas Jefferson University Department of Otolaryngology, Philadelphia, Pennsylvania
Conditions: Obstructive Sleep Apnea
Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors
Recruiting
This phase III trial studies how well bupropion works in reducing cancer related fatigue in cancer survivors. Bupropion is a drug that is used to treat depression, as well as to help people quit smoking. Cancer and its treatment can cause fatigue. Giving bupropion may improve cancer related fatigue in cancer survivors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Conditions: Be Diagnosed With Cancer and Have Completed Systemic Therapy
Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2
Recruiting
The objective of this study is to compare the safety and efficacy of RGN-259 to placebo for the treatment of Neurotrophic Keratopathy (NK)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: UPMC Eye Center, Pittsburgh, Pennsylvania
Conditions: Neurotrophic Keratopathy
Early Antenatal Support for Iron Deficiency Anemia
Recruiting
This is a randomized, controlled multi-site trial of iron therapy in pregnancy. The purpose of this research is to see if second trimester initiation of intravenous (IV) iron therapy is better than oral iron therapy for treatment of anemia in pregnancy by improving blood count, quality of life and reducing side effects.
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
04/17/2024
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Pregnancy Related, Anemia, Iron Deficiency, Anemia of Pregnancy
Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation
Recruiting
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems.
Gender:
ALL
Ages:
All
Trial Updated:
04/17/2024
Locations: Penn State Health / Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Infusion Reactions