Pennsylvania is currently home to 3459 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Safety and Tolerability Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD)
NCT05616793
Recruiting
The goal of this clinical trial is to evaluate the safety and preliminary efficacy of subretinal gene therapy with OPGx-001 in patients with inherited retinal degeneration due to biallelic mutations in the LCA5 gene.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/15/2023
Locations: University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
Conditions: LCA5
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Glioma Supra Marginal Incision Trial
NCT04737577
Recruiting
G-SUMIT is a pilot, phase II,randomized controlled trial to evaluate the feasibility of performing a large-scale trial in patients undergoing surgery for first-time diagnosis of high grade glioma (HGG) in a surgically favorable anatomical location to answer the following: Does extending the margin of resection 1 cm beyond visible enhanced volume on MRI result in (a) an increase in overall survival? (b) result in a similar rate of "clinically-significant" neurological worsening during 30 days po... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
06/15/2023
Locations: The Pennsylvania State University, University Park, Pennsylvania
Conditions: High Grade Glioma
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Therapy and Peer Support for Patients Taking Medication for Opioid Use Disorder
NCT04257214
Recruiting
Current clinical guidelines for medication assisted treatment (MAT) of opioid use disorder (OUD) recommend that treatment include a psychosocial component to help address psychological factors related to addiction. However, a knowledge gap exists regarding the most effective forms of psychosocial intervention and what interventions are most effective for different types of patients. This gap represents a significant barrier to the widespread implementation of effective office-based opioid treatm... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/15/2023
Locations: Philadelphia FIGHT, Philadelphia, Pennsylvania
Conditions: Opioid Use Disorder
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A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling
NCT04773782
Recruiting
This is a Phase 1/2, multicenter, open-label trial of avapritinib in participants 2 to < 18 years of age with advanced relapsed/refractory (R/R) solid tumors, including central nervous system (CNS) tumors, that harbor a PDGFRA and/or KIT mutation (including non-synonymous point mutations, insertions, and deletions) or amplification, or DMG-H3K27a who have no available curative treatment options. This is a single-arm trial in which all participants will receive avapritinib. The study consists of... Read More
Gender:
All
Ages:
Between 2 years and 17 years
Trial Updated:
06/14/2023
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Solid Tumor, Unspecified, Child, Relapsed Solid Neoplasm, CNS Tumor
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Measuring Automated Behavioral Observations & Vocal Expressions (ABOVE)
NCT03459456
Recruiting
The investigators propose to synchronize automated measurements of behavior - head, body, and face dynamics, gaze, and vocal prosody - with simultaneous recordings of brain activity in clinically relevant contexts.
Gender:
All
Ages:
Between 21 years and 70 years
Trial Updated:
06/14/2023
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: OCD, Obsessive-Compulsive Disorder
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Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome
NCT00556530
Recruiting
22q11.2 deletion syndrome is a genetic disorder that can cause heart defects, facial abnormalities, and developmental and learning disabilities. The severity of the disorder can vary widely among people. This study will analyze DNA from people with 22q11.2 deletion syndrome to identify genetic variations that may affect the severity of the disorder.
Gender:
All
Ages:
All
Trial Updated:
06/14/2023
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: DiGeorge Syndrome, 22q11.2 Deletion Syndrome
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Longitudinal ctDNA Surveillance for Older Women With ER+ Breast Cancer Who Omit Surgery
NCT05914792
Recruiting
This prospective study recruits patients with ER+/HER2-, non-metastatic breast cancer who omit upfront surgery in favor of primary endocrine therapy for sample collection and prospective circulating tumor DNA (ctDNA) measurement to guide disease surveillance.
Gender:
Female
Ages:
70 years and above
Trial Updated:
06/13/2023
Locations: UPMC Magee Womens Hospital - Surgical Oncology, Pittsburgh, Pennsylvania
Conditions: Breast Cancer
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Spinal Cord Stimulation in Spinal Muscular Atrophy
NCT05430113
Recruiting
Spinal cord stimulation (SCS) has shown remarkable efficacy in restoring motor function in people with spinal cord injury by recruiting afferent input to enhance the responsiveness of spared neural circuits to residual cortical inputs. This pilot will test if SCS can show evidence to improve motor deficits in people with type 3 or 4 spinal muscular atrophy (SMA). The investigators will enroll up to six subjects with Type 3 or 4 SMA aged 16 or older that show quantifiable motor deficits of the le... Read More
Gender:
All
Ages:
Between 16 years and 64 years
Trial Updated:
06/13/2023
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Spinal Muscular Atrophy Type 3, Spinal Muscular Atrophy Type 4
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Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
NCT01484678
Recruiting
The purpose of this research study is to determine the potential of magnetic resonance imaging, spectroscopy, and whole body imaging to monitor disease progression and to serve as an objective outcome measure for clinical trials in Muscular Dystrophy (MD). The investigators will compare the muscles of ambulatory or non-ambulatory boys/men with DMD with muscles of healthy individuals of the same age and monitor disease progression in those with DMD over a 5-10 year period. The amount of muscle d... Read More
Gender:
Male
Ages:
Between 5 years and 62 years
Trial Updated:
06/13/2023
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
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Mammogram Mail- and Phone-based Interventions
NCT05853848
Recruiting
The project aims to evaluate four different versions and modalities of interventions encouraging mammogram screening among all eligible women due or overdue for screening. The evaluation will compare among the following forms of outreach to help determine whether (a) live calls are more effective at increasing mammogram screening than other forms of outreach and (b) each form of outreach is more effective than no outreach: (1) a postcard, (2) a letter, (3) an auto-dialer phone message, and (4) a... Read More
Gender:
Female
Ages:
Between 51 years and 74 years
Trial Updated:
06/12/2023
Locations: Geisinger, Danville, Pennsylvania
Conditions: Breast Cancer
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IO102-IO103 in Combination With Pembrolizumab as First-line Treatment for Patients With Metastatic NSCLC, SCCHN, or mUBC
NCT05077709
Recruiting
A Phase II Multi-Arm (basket) Trial Investigating the Safety and Efficacy of IO102-IO103 in Combination with pembrolizumab, as First-line Treatment for Patients with Metastatic Non-Small Cell Lung Cancer (NSCLC), Squamous Cell Carcinoma of Head or Neck (SCCHN), or Metastatic Urothelial Bladder Cancer (mUBC)
Gender:
All
Ages:
18 years and above
Trial Updated:
06/09/2023
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Lung Cancer Non Small Cell, Head and Neck Squamous Cell Carcinoma, Urothelial Carcinoma Bladder
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A Prospective Natural History Study in Uveal Melanoma
NCT04588662
Recruiting
The overall objective of this proposal is to develop and utilize a multicenter UM registry that will, in a longitudinal fashion, capture prospective data in order to characterize the natural history of UM and provide data that will be used to support the development of novel therapies for this disease. The care of patients with UM requires a multi-disciplinary team of physicians that commonly requires the involvement of both radiation oncology and interventional radiology, and is typically direc... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/09/2023
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Uveal Melanoma
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