Pennsylvania is currently home to 3313 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability
NCT03900832
Recruiting
The study objectives of this projects are to examine the hypothesis that the sympathetic and blood pressure responses to exercise will be attenuated during and after heat exposure in patients with peripheral artery disease, via altering the sensitivity of the muscle afferent receptors.
Gender:
ALL
Ages:
Between 21 years and 85 years
Trial Updated:
04/03/2024
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: PAD
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A Translational Understanding of Obesity-Related Phenotypes Using Brain Imaging and Manipulation
NCT06353464
Recruiting
This study will examine a potential relationship between family history of obesity, that is whether people with at least one parent who had obesity in adulthood compared to people with two parents who did not have obesity in adulthood, and the ability of protein intake to curb further intake of food.
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
04/02/2024
Locations: Drexel University, Philadelphia, Pennsylvania
Conditions: Obesity
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Study of AT-02 in Healthy Volunteers and Subjects With Systemic Amyloidosis
NCT05521022
Recruiting
This is a multicenter, international, three-part, Phase 1 study designed to evaluate the safety, tolerability, and PK of rising single doses of AT-02 in healthy volunteers and in subjects with systemic amyloidosis and to assess the safety, tolerability, and PK of multiple doses of AT-02 in subjects with systemic amyloidosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2024
Locations: Penn Presbyterian Medical Center, Philadelphia, Pennsylvania
Conditions: Amyloidosis; Systemic
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The Effects of Open Chain Versus Closed Chain Strengthening on Dynamic Valgus During a Step Down Test
NCT06348836
Recruiting
The goal of this clinical trial is to compare the effects of different exercises programs in individuals with abnormal knee motion. The main question it aims to answer are: * In individuals with abnormal knee motion and without knee pain, does a weight-bearing exercise program reduce abnormal knee motion during a step-down test better than a non weight-bearing exercise program? Participants will * Perform a stepdown test while undergoing motion analysis and electromyograph (EMG) recording. * Pa... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/30/2024
Locations: Alvernia University, Reading, Pennsylvania
Conditions: Dynamic Knee Valgus
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Determination and Validation of a Multi-analyte Assay for Lung Cancer Screening
NCT04968548
Recruiting
This study is part of the development and validation of a non-invasive lung screening test which aim to identify early stage lung cancer in patients at high risk for lung cancer.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
03/28/2024
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Lung Cancer
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Pediatric Percutaneous Ultrasound Gastrostomy Technique
NCT05966311
Recruiting
The purpose of this research study is to test a new device called the PUMA-G Pediatric System. The research will measure if the device works well to safely aid doctors placing gastrostomy feeding tubes in children. The PUMA-G Pediatric System is an investigational device that uses ultrasound and magnets to guide insertion of a feeding tube.
Gender:
ALL
Ages:
Between 0 years and 21 years
Trial Updated:
03/27/2024
Locations: Children's Hospital Of Phildelphia, Philadelphia, Pennsylvania
Conditions: Gastrostomy, Gastrostomy Complications, Pediatric Disorder, Ultrasound
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Low Dose Vasopressin vs Phenylephrine in Cardiac Surgery
NCT04602767
Recruiting
This is a randomized, open label study to investigate vasopressin versus phenylephrine as a first line pressor in cardiac surgery. All patients \>18 years of age presenting for coronary artery bypass graft (CABG), valve surgery, or combined CABG and valve surgery will be screened for inclusion. Patients with ejection fraction \< 35%, \> moderate pulmonary hypertension, \> mild right ventricular dysfunction, a planned radial arterial graft, or circulatory arrest will be excluded. Patients will be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: Thomas Jefferson Univesity, Philadelphia, Pennsylvania
Conditions: Acute Kidney Injury
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Nirvana Super Pro Supplementation in Orthopedic Surgery Patients
NCT06203691
Recruiting
The purpose of this study is to investigate orthopedic patients undergoing either a total hip replacement (THR) or total knee arthroplasty (TKR) using two dietary supplements, PREPARE and RECOVER, and their recovery times post-surgery.
Gender:
ALL
Ages:
Between 45 years and 80 years
Trial Updated:
03/26/2024
Locations: University Orthopedics Center, Altoona, Pennsylvania
Conditions: Arthropathy of Knee, Arthropathy of Hip
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Food for Thought: Executive Functioning Around Eating Among Children
NCT06108128
Recruiting
Scientific knowledge of the cognitive-developmental processes that serve to support children's appetite self-regulation are surprisingly limited. This investigation will provide new scientific directions for obesity prevention by elucidating cognitive-developmental influences on young children's ability to make healthy food choices and eat in moderation.
Gender:
ALL
Ages:
Between 4 years and 6 years
Trial Updated:
03/25/2024
Locations: Temple University, Philadelphia, Pennsylvania
Conditions: Self-regulation, Appetitive Behavior, Eating Behavior, Child Obesity
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Impact of XDEMVY® on Demodex Blepharitis in Soft Contact Lens Wearers
NCT06182358
Recruiting
To compare the efficacy of XDEMVY ophthalmic drop to its vehicle control for the treatment of Demodex blepharitis and its impact on the soft contact lens wearing experience.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/22/2024
Locations: Site, Cranberry Township, Pennsylvania
Conditions: Demodex Blepharitis
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Tau PET Imaging in Opioid Use Disorder
NCT05651516
Recruiting
The investigators plan to enroll up to 60 adult subjects in this study. There will be three groups of up to 20 subjects each in this study. Group 1: individuals with OUD and a history of at least one opioid-related OD in the past 5 years that required naloxone treatment reversal: OUD/OD+ Group 2: individuals with OUD without a lifetime history of opioid-related OD OUD/OD- Group 3: Healthy controls without a lifetime OUD: HCs PET/CT imaging will be used to evaluate the uptake of tau in the brain... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/21/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Opioid-Related Disorders
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Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis
NCT04028492
Recruiting
To investigate the safety and efficacy of tradipitant versus placebo in relieving nausea and other symptoms of gastroparesis.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/19/2024
Locations: Vanda Investigational Site, Philadelphia, Pennsylvania
Conditions: Idiopathic Gastroparesis, Diabetic Gastroparesis, Gastroparesis
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