Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Nirvana Super Pro Supplementation in Orthopedic Surgery Patients
NCT06203691
Recruiting
The purpose of this study is to investigate orthopedic patients undergoing either a total hip replacement (THR) or total knee arthroplasty (TKR) using two dietary supplements, PREPARE and RECOVER, and their recovery times post-surgery.
Gender:
ALL
Ages:
Between 45 years and 80 years
Trial Updated:
03/26/2024
Locations: University Orthopedics Center, Altoona, Pennsylvania
Conditions: Arthropathy of Knee, Arthropathy of Hip
Register for Updates
Food for Thought: Executive Functioning Around Eating Among Children
NCT06108128
Recruiting
Scientific knowledge of the cognitive-developmental processes that serve to support children's appetite self-regulation are surprisingly limited. This investigation will provide new scientific directions for obesity prevention by elucidating cognitive-developmental influences on young children's ability to make healthy food choices and eat in moderation.
Gender:
ALL
Ages:
Between 4 years and 6 years
Trial Updated:
03/25/2024
Locations: Temple University, Philadelphia, Pennsylvania
Conditions: Self-regulation, Appetitive Behavior, Eating Behavior, Child Obesity
Register for Updates
Tau PET Imaging in Opioid Use Disorder
NCT05651516
Recruiting
The investigators plan to enroll up to 60 adult subjects in this study. There will be three groups of up to 20 subjects each in this study. Group 1: individuals with OUD and a history of at least one opioid-related OD in the past 5 years that required naloxone treatment reversal: OUD/OD+ Group 2: individuals with OUD without a lifetime history of opioid-related OD OUD/OD- Group 3: Healthy controls without a lifetime OUD: HCs PET/CT imaging will be used to evaluate the uptake of tau in the brain... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/21/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Opioid-Related Disorders
Register for Updates
Metastatic Tumor Research and Outcomes Network
NCT02830451
Recruiting
The registry aims to collect patient information such as patient demographics, co-morbidities, clinical, diagnostic, and therapeutic data, as well as information on adverse events and HRQOL outcomes specific for patients with metastatic spine tumor(s).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2024
Locations: Penn Presbyterian Medical Center Department of Neurosurgery, Philadelphia, Pennsylvania
Conditions: Metastatic Spine Tumor
Register for Updates
Rectal Spacer for Prostate Cancer Radiation Image Guidance
NCT05650021
Recruiting
The purpose of the study is to determine if a radiopaque hydrogel rectal spacer, SpaceOAR Vue®, can be used in place of fiducial markers when aligning patients for radiotherapy. The investigator hypothesizes that the alignment of the patient based on the rectal spacer will be similar to the alignment of the patient with fiducial markers.
Gender:
MALE
Ages:
All
Trial Updated:
03/18/2024
Locations: Penn State Cancer Institute, Hershey, Pennsylvania
Conditions: Prostate Cancer
Register for Updates
I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
NCT04488081
Recruiting
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients. In this phase 2 platform design, agents will be identified with a signal suggesting a big impact on reducing mortality and the need for, as well as duration, of mechanical ventilation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/15/2024
Locations: University of Pennsylvania (U Penn), Philadelphia, Pennsylvania
Conditions: COVID-19
Register for Updates
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT06322693
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: GSK Investigational Site, Bethlehem, Pennsylvania
Conditions: Neoplasms
Register for Updates
Connective Tissue Matrix for Rotator Cuff Tendinopathy
NCT06160427
Recruiting
The purpose of this research study is to determine if the effectiveness of a single injection of CTM Boost in the treatment of patients with rotator cuff tendinopathy (RCT) is as effective as a single injection of platelet rich plasma (PRP) in reducing the symptoms of RCT.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/14/2024
Locations: Allegheny Health Network Allegheny General Hospital, Pittsburgh, Pennsylvania
Conditions: Tendinopathy, Shoulder Pain, Rotator Cuff Tendinitis, Rotator Cuff Tendinosis
Register for Updates
A Study to Evaluate Safety, Efficacy, and Pharmacokinetics in Participants With Advanced Solid Tumors
NCT04903873
Recruiting
Phase 1 (Dose Escalation) of this study will assess the safety, tolerability, dose-limiting toxicity (DLT), and will determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of EU101 in participants with advanced solid tumors. Phase 2 (Dose Expansion) of the study will assess the antitumor effect of EU101 in two indications including colorectal cancer (CRC) and non-small cell lung cancer (NSCLC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2024
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Solid Tumor, Non-Small Cell Lung Cancer, Renal Cell Cancer Metastatic, Renal Cell Carcinoma, Prostate Cancer
Register for Updates
ViSiGi LUX Bariatric Sizing and Calibration System
NCT06282094
Recruiting
This study investigates the new ViSiGi LUX.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/11/2024
Locations: WellSpan, York, Pennsylvania
Conditions: Bariatric Surgery Candidate
Register for Updates
Evaluation of Sleep Quality in Head and Neck Cancer Patients Throughout Treatment Course
NCT05108233
Recruiting
This study examines how head and neck cancer treatment affects quality of sleep over time and factors that contribute to sleep quality. Sleep plays a critical role in healing and quality of life, and recent studies investigating sleep disorders in head and neck cancer patients reveal sleep quality is a major determinant of post-treatment outcomes. Information from this study may help researchers better understand how treatment impacts sleep quality so that they can make changes that may help imp... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Malignant Head and Neck Neoplasm
Register for Updates
LOWER: Lomitapide Observational Worldwide Evaluation Registry
NCT02135705
Recruiting
This global product exposure registry is a multicentre, long-term, prospective, observational cohort study (exposure registry), designed to evaluate the long term safety and effectiveness of lomitapide.
Gender:
ALL
Ages:
All
Trial Updated:
03/11/2024
Locations: The Heart Care Group, PC, Allentown, Pennsylvania
Conditions: Homozygous Familial Hypercholesterolemia
Register for Updates