Pennsylvania is currently home to 3463 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
MIT-001 for Prevention of CCRT-Induced OM in HNSCC Patients
NCT04651634
Recruiting
The proposed study in patients with previously untreated locally advanced head and neck squamous cell carcinoma (HNSCC) is designed to evaluate the efficacy and safety of three different doses of MIT-001 compared to the placebo in prevention of oral mucositis (OM) in patients with HNSCC who are undergoing concurrent chemoradiotherapy (CCRT).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/21/2023
Locations: University of Pittsburgh Medical Center - Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Oral Mucositis, Head and Neck Squamous Cell Carcinoma
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Performance Evaluation of Daily Disposable Contact Lenses in Habitual Lens Wearers Who Use Digital Devices Frequently
NCT05805150
Recruiting
The goal of this study is to compare the performance of two daily disposable silicone hydrogel lenses.
Gender:
All
Ages:
Between 18 years and 35 years
Trial Updated:
04/19/2023
Locations: Nittany Eye Associate, State College, Pennsylvania
Conditions: Myopia
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Efficacy of Tranexamic Acid (TXA) in Humerus ORIF
NCT05802238
Recruiting
The purpose of this study is to determine if administration of tranexamic acid (TXA), a clotting agent, will decrease blood loss, the need for transfusion, and reduce the likelihood of wound complications such as infection. Investigators will also see if the drug can effectively decrease operative time and length of hospitalization.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
04/19/2023
Locations: Allegheny Health Network Allegheny General Hospital, Pittsburgh, Pennsylvania
Conditions: Fracture Humerus
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Feasibility Study of Intra-Tumoral Lipopolysaccharide Immunotherapy for Intra-Abdominal
NCT05751837
Recruiting
The purpose of this research study is to determine whether a sterile bacteria wall chemical, called lipopolysaccharide (LPS), can be injected safely into abdominal tumors during routine laparoscopic surgery performed as a preliminary procedure in patients who will subsequently undergo a larger planned operation to remove abdominal tumors. The researchers will biopsy the tumor before injection and then again at the time of the larger operation to assess whether any effect of the treatment can be... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
04/19/2023
Locations: Allegheny Health Network Allegheny General Hospital, Pittsburgh, Pennsylvania
Conditions: Abdominal Cancer, Malignancy
Register for Updates
Circadian Rhythms and Homeostatic Sleep Drive and Their Effect on Reward and Cognitive Control Systems in Adolescents
NCT05336084
Recruiting
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their sleep/wake patterns paired with early school start times, which may increase the risk for substance use (SU). However, what impact circadian rhythm and sleep disruption either together or independently have on the neuronal circuitry that controls reward and cognition, or if... Read More
Gender:
All
Ages:
Between 13 years and 15 years
Trial Updated:
04/19/2023
Locations: Western Psychiatric Hospital, Pittsburgh, Pennsylvania
Conditions: Sleep
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Evaluation of Vision-Guided Shared Control for Assistive Robotics Manipulators
NCT04323449
Recruiting
The purpose of this study is to evaluate a new control (i.e., the vision-guided shared control) for a wheelchair-mounted assistive robotic manipulator among powered wheelchair users. This study will consist of a questionnaire about general demographics, health information, and previous experience with assistive technology. Several tests will also be administered to test upper extremity function and ability as well as to test spatial orientation and visualization ability. Participants till then u... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/19/2023
Locations: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania
Conditions: Spinal Cord Injury/Disorder
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A Clinical Investigation to Follow the Progress of Exuding Chronic Venous Leg Ulcers Using a Non-Bordered Foam Dressing
NCT05608317
Recruiting
The goal of this clinical trial to follow the progress of wounds in those with chronic venous leg ulcers while using a non-bordered foam dressing. The main objective is to follow the progress of these wounds over time from initial visit to each follow-up visit. Participants will be asked to wear the dressing for up to 6 weeks of treatment or until healed, changed at every one-week interval.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2023
Locations: Serena Group Research Institute, Pittsburgh, Pennsylvania
Conditions: Wounds, Wound of Skin, Wound Leg, Venous Leg Ulcer
Register for Updates
A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.
NCT05588583
Recruiting
The goal of this clinical trial is to follow the progress of wounds in those with venous leg ulcers and diabetic foot ulcers while using an absorbent dressing called Mepilex Up. The main objective is to follow the progress of these wounds over time from initial visit to each follow-up visit. Participants will be asked to wear Mepilex Up dressing for up to 6 weeks of treatment or until healed, changed at every one-week interval.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2023
Locations: Serena Group Research Institute, Pittsburgh, Pennsylvania
Conditions: Wounds, Wound of Skin, Wound Leg, Wound; Foot, Diabetic Foot Ulcer, Venous Leg Ulcer
Register for Updates
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
NCT04174157
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. Until recently, the mainstay of treatment for these patients was supportive medical care. Howe... Read More
Gender:
All
Ages:
All
Trial Updated:
04/18/2023
Locations: Penn State Hershey, Hershey, Pennsylvania
Conditions: Spinal Muscular Atrophy (SMA)
Register for Updates
Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia
NCT04109820
Recruiting
MitoQ is commercially available as a dietary supplement and it has been tested as a potential drug in other diseases, but it has never been tested in patients with sickle cell disease. The goal of this research is to study if MitoQ, a molecule that works as an antioxidant by removing potentially damaging agents in a living organism, improves platelet function in patients with sickle cell disease (SCD).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2023
Locations: Magee Women's Hospital, Pittsburgh, Pennsylvania
Conditions: Sickle Cell Disease
Register for Updates
Clinical Outcomes Study of the Nexel Total Elbow
NCT02469662
Recruiting
The objectives of the study are to confirm safety and performance of the Zimmer Nexel Total Elbow when used in primary or revision total elbow replacement.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2023
Locations: Rothman Institute, Philadelphia, Pennsylvania
Conditions: Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis, Joint Instability or Loss of Motion, Acute Comminuted Articular Fracture of Elbow Joint Surfaces, Bone Loss Contributing to Elbow Instability, Bilateral Ankylosis From Causes Other Than Active Sepsis, Post-traumatic Arthritis, Degenerative Arthritis
Register for Updates
Consistently Assess Signs and Symptom of Heart Failure
NCT05833581
Recruiting
Heart failure (HF) is a major public health problem. The New York Heart Association (NYHA) Functional Classification by a HF provider helps to guide their decisions in patient treatment. The purpose of this study is to further examine the NYHA Classification Guide that is designed to assist healthcare providers. The investigators will conduct the study in the outpatient clinic setting where adult patients with chronic heart failure are treated. HF providers will be asked to complete the NYHA cla... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
04/17/2023
Locations: Lancaster General Health/Penn Medicine, Lancaster, Pennsylvania
Conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
Register for Updates