Pennsylvania is currently home to 3317 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Endotypic Stability in CRS
NCT06272123
Recruiting
A Case control study with 150 cases and 50 controls will be conducted. Immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (Lund-Mackay and Lund-Kennedy score, lung function tests), surveys (SNOT- 22, SF-36 quality of life survey) will be compared between different groups of patients
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
02/20/2024
Locations: Thomas Jefferson University Department of Otolaryngology, Philadelphia, Pennsylvania
Conditions: Chronic Sinusitis
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Utility and Usability of ActivSight™ Laser Speckle Imaging in Visualization of Tissue Perfusion and Blood Flow During Esophageal Surgery in Humans
NCT05591053
Recruiting
ActivSight™ combines an innovative form factor and proprietary software to deliver precise, objective, real-time visualization of blood flow and tissue perfusion intraoperatively for laparoscope-based surgery. A small adaptor that fits between any existing laparoscope and camera systems and a separate light source placed along any current commercial system will deliver objective real-time tissue perfusion and blood flow information intraoperatively. Primary Objective: To determine the feasibili... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/20/2024
Locations: University of Pittsburgh Medical Center - Dept of Cardiothoracic Surgery, Pittsburgh, Pennsylvania
Conditions: Esophagus Cancer, Esophageal Cancer, Esophageal Neoplasms, Esophageal Diseases, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Esophagus SCC, Esophagus Tumor, Esophagus Adenocarcinoma, Esophagus Neoplasm
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Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection
NCT05959629
Recruiting
The purpose of this study is to develop a protocol for biofilms disinfection with a FDA cleared, clinically approved and commercially available Er,Cr:YSGG laser treatments. This protocol will be testing local single topical application of Lasers within the canal system in patients going through routine endodontic treatment, evaluate its potential as anti-biofilm treatment and compare it to other currently used antibacterial protocols.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/15/2024
Locations: University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania
Conditions: Endodontic Disease, Root Canal Infection
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Contrast-Enhanced Ultrasound Scan for the Estimation of Tissue Pressure in Patients With Breast Cancer
NCT04721886
Recruiting
This clinical trial studies the use of contrast-enhanced ultrasound (CEUS) in estimating tissue pressure in patients with breast cancer. Diagnostic procedures, such as CEUS, may help estimate tissue pressure noninvasively.
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
02/14/2024
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Breast Carcinoma
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InformationSeekingMesolimbicEngagementStudy1
NCT06257446
Recruiting
Study 1 will use a novel Game Show task, in which the investigators manipulate participant's agency to control their learning environment to specify unguided exploration.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
02/12/2024
Locations: Temple University, Philadelphia, Pennsylvania
Conditions: Motivation
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InformationSeekingMesolimbicEngagementStudy2
NCT06257433
Recruiting
Participants will complete a treasure task during neuroimaging where they have to learn which keys open a treasure chest, and then they are tested on the contents of the treasure chest.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
02/12/2024
Locations: Temple University, Philadelphia, Pennsylvania
Conditions: Motivation
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Longitudinal Study of Urea Cycle Disorders
NCT00237315
Recruiting
Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on the natural history, disease progression, treatment, and outcome of individuals with UCD.
Gender:
ALL
Ages:
All
Trial Updated:
02/10/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Brain Diseases, Metabolic, Inborn, Amino Acid Metabolism, Inborn Errors, Urea Cycle Disorders
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Strength and Muscle Related Outcomes for Nutrition and Lung Function in CF
NCT05639556
Recruiting
The goal of the study is to examine multiple markers of anthropometrics, body composition, sarcopenia and frailty and compare them to dual energy X-ray absorptiometry (DXA) output, which is considered the current clinical gold-standard tool to measure body composition. The result of this study will provide detailed data regarding the nutrition and body composition within this Cystic Fibrosis population and also provide a baseline evaluation for use of these biomarkers in the future studies inclu... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/09/2024
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Cystic Fibrosis
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Enhancing PAP Adherence Among Spanish-speaking Hispanic Adults With OSA
NCT05618444
Recruiting
This study seeks to enhance long-term positive airway pressure (PAP) adherence among Spanish-speaking Hispanics, a group with known PAP outcomes disparities. This study will assess the feasibility of a linguistically and culturally adapted tele-management intervention (Automated Management, AM) for Spanish-speaking Hispanic adults with OSA.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2024
Locations: Geisinger, Danville, Pennsylvania
Conditions: Obstructive Sleep Apnea
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A Study to Investigate CYC140, in Subjects With Advanced Solid Tumors and Lymphoma
NCT05358379
Recruiting
This is a 2-part, phase 1/2, open-label, multicenter study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, pharmacogenomics, and efficacy of CYC140 administered orally daily. This study consists of Phase 1 and Phase 2 components in subjects with advanced solid tumors and lymphoma who have progressed despite having standard therapy or for which no standard therapy exists.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Solid Tumor, Adult Lymphoma
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Trisol System EFS Study
NCT04905017
Recruiting
The objective of this early feasibility study is to gain early clinical insight into Trisol system safety and performance to treat patients with moderate or greater tricuspid regurgitation (TR).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: Main Line Health / Lankenau Institute for Medical Research, Wynnewood, Pennsylvania
Conditions: Tricuspid Regurgitation
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A Global Prospective Observational Study of Women With Fabry Disease and Their Infants During Pregnancy and Breastfeeding
NCT04252066
Recruiting
This is a global prospective observational study of women with Fabry disease and their infants during pregnancy and/or breastfeeding. The study will evaluate outcomes of pregnancy and/or breastfeeding in women and infants exposed to migalastat.
Gender:
FEMALE
Ages:
All
Trial Updated:
02/06/2024
Locations: Amicus Therapeutics, Inc. Pregnancy Registry, Philadelphia, Pennsylvania
Conditions: Fabry Disease
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