Pennsylvania is currently home to 3297 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection
NCT05959629
Recruiting
The purpose of this study is to develop a protocol for biofilms disinfection with a FDA cleared, clinically approved and commercially available Er,Cr:YSGG laser treatments. This protocol will be testing local single topical application of Lasers within the canal system in patients going through routine endodontic treatment, evaluate its potential as anti-biofilm treatment and compare it to other currently used antibacterial protocols.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/15/2024
Locations: University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania
Conditions: Endodontic Disease, Root Canal Infection
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Contrast-Enhanced Ultrasound Scan for the Estimation of Tissue Pressure in Patients With Breast Cancer
NCT04721886
Recruiting
This clinical trial studies the use of contrast-enhanced ultrasound (CEUS) in estimating tissue pressure in patients with breast cancer. Diagnostic procedures, such as CEUS, may help estimate tissue pressure noninvasively.
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
02/14/2024
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Breast Carcinoma
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InformationSeekingMesolimbicEngagementStudy2
NCT06257433
Recruiting
Participants will complete a treasure task during neuroimaging where they have to learn which keys open a treasure chest, and then they are tested on the contents of the treasure chest.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
02/12/2024
Locations: Temple University, Philadelphia, Pennsylvania
Conditions: Motivation
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Longitudinal Study of Urea Cycle Disorders
NCT00237315
Recruiting
Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on the natural history, disease progression, treatment, and outcome of individuals with UCD.
Gender:
ALL
Ages:
All
Trial Updated:
02/10/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Brain Diseases, Metabolic, Inborn, Amino Acid Metabolism, Inborn Errors, Urea Cycle Disorders
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Enhancing PAP Adherence Among Spanish-speaking Hispanic Adults With OSA
NCT05618444
Recruiting
This study seeks to enhance long-term positive airway pressure (PAP) adherence among Spanish-speaking Hispanics, a group with known PAP outcomes disparities. This study will assess the feasibility of a linguistically and culturally adapted tele-management intervention (Automated Management, AM) for Spanish-speaking Hispanic adults with OSA.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2024
Locations: Geisinger, Danville, Pennsylvania
Conditions: Obstructive Sleep Apnea
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A Study to Investigate CYC140, in Subjects With Advanced Solid Tumors and Lymphoma
NCT05358379
Recruiting
This is a 2-part, phase 1/2, open-label, multicenter study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, pharmacogenomics, and efficacy of CYC140 administered orally daily. This study consists of Phase 1 and Phase 2 components in subjects with advanced solid tumors and lymphoma who have progressed despite having standard therapy or for which no standard therapy exists.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Solid Tumor, Adult Lymphoma
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Trisol System EFS Study
NCT04905017
Recruiting
The objective of this early feasibility study is to gain early clinical insight into Trisol system safety and performance to treat patients with moderate or greater tricuspid regurgitation (TR).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: Main Line Health / Lankenau Institute for Medical Research, Wynnewood, Pennsylvania
Conditions: Tricuspid Regurgitation
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Reduction of Adverse Drug Events and Readmissions
NCT02738047
Recruiting
Pharmocogenomic test assessment in the medication regimen and disease management for patients under drugs known with genetic variation.
Gender:
ALL
Ages:
25 years and above
Trial Updated:
02/06/2024
Locations: MD@Home, York, Pennsylvania
Conditions: Pharmacogenomic Testing for Medication Management
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The Impact of Retropubic Lidocaine vs Saline on Postoperative Urinary Retention Following Midurethral Sling
NCT03913845
Recruiting
Stress urinary incontinence affects millions of women worldwide and has a profound impact on the quality of life of older individuals, their subjective health status, levels of depression and need for care. Midurethral sling placement was introduced in 1995 and remains the current gold standard for surgical management of SUI. Although the advantages of midurethral sling surgery include its high success and minimally invasive approach, approximately 10-50% of women experience acute postoperative... Read More
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
02/05/2024
Locations: AHN Bethel Park Health + Wellness Pavilion, Bethel Park, Pennsylvania
Conditions: Stress Urinary Incontinence
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Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies
NCT04137900
Recruiting
The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB004 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB004, 2) evaluate antitumor activity of TAB004... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Advanced Unresectable Solid Tumor, Metastatic Solid Tumor
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The Acute Burn ResUscitation Multicenter Prospective Trial
NCT04356859
Recruiting
This is a prospective randomized multi-center study which will compare acute fluid resuscitation using a colloid strategy (LR + 5% Albumin) to a crystalloid strategy (LR alone), in adults with an acute burn involving at least 25% of their total body surface area.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2024
Locations: West Penn Hospital, Pittsburgh, Pennsylvania
Conditions: Burn Injury
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A Study of AT-02 in Subjects With Systemic Amyloidosis.
NCT05951049
Recruiting
This is a Phase 2 open-label extension study to evaluate the long-term safety, tolerability, and clinical activity of AT-02. AT-02 is an investigational medicinal product being developed to treat systemic amyloidosis.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/29/2024
Locations: Penn Presbyterian Medical Center, Philadelphia, Pennsylvania
Conditions: Amyloidosis; Systemic
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