Pennsylvania is currently home to 3466 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Pharmacokinetics, Safety and Efficacy of Nemolizumab in Participants With Moderate-to-Severe Atopic Dermatitis
Recruiting
The purpose of this study is to assess the pharmacokinetics (PK), efficacy, and safety of nemolizumab in pediatric participants with moderate-to-severe atopic dermatitis (AD).
Gender:
All
Ages:
Between 2 years and 12 years
Trial Updated:
04/05/2023
Locations: Galderma Investigational Site #8255, Philadelphia, Pennsylvania
Conditions: Moderate-to-Severe Atopic Dermatitis
Impact of Parental Emotion Regulation on the Treatment of ADHD
Recruiting
Aim: To examine if parental emotion regulation (ER) moderates the response to parent training interventions. H1: Reduced parental ER capacity will predict diminished efficacy for behavioral parent training to improve negative parenting behavior (NPB) and behavior problems in offspring with ADHD. H2: Increased parental emotional reactivity will predict diminished efficacy for behavioral parent training to improve negative parenting behavior (NPB) and behavior problems in offspring with ADHD.
Gender:
All
Ages:
Between 5 years and 12 years
Trial Updated:
04/04/2023
Locations: Penn State Health Dept of Psychiatry, Hershey, Pennsylvania
Conditions: ADHD
The Hancock Jaffe Surgical Antireflux Venous Valve Endoprosthesis Study
Recruiting
A prospective, non blinded, single arm, multicenter study designed to assess the safety and effectiveness of the bioprosthetic, VenoValve, which is surgically implanted into the deep venous system for treatment of patients with deep venous valvular insufficiency ( C4b-C6 patients).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2023
Locations: UPMC, Pittsburgh, Pennsylvania
Conditions: Deep Venous Insufficiency (Diagnosis)
A Study of Surgical Interventions in Fistulizing Conditions
Recruiting
In this study, participants with complex fistulizing conditions will be treated with surgical interventions according to their clinic's standard practice. The aim of the study is to generate real-world evidence on standard of care for surgical interventions and related outcomes when treating complex fistulizing conditions. The study sponsor will not be involved in how participants are treated but will provide instructions on how the clinics will record what happens during the study.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2023
Locations: Penn Medicine PA, Philadelphia, Pennsylvania
Conditions: Crohns Disease, Fistula, Rectovaginal Fistula, Complex Perianal Fistula, Complex Cryptoglandular Fistula
PennPET Explorer Scanner Evaluation
Recruiting
Positron Emission Tomography (PET) is a procedure that uses a special type of machine to take pictures of the inside of the body after a radioactive drug is administered. The radioactive drug that is used for this study may be an FDA approved imaging drug or may be used as an investigational imaging drug as part of another study for which participants are taking part. PET using various radiotracers is useful for the diagnosis of various diseases, including cancer, brain diseases, infection, and... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2023
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Healthy, Cognitive Impairment
Evaluating Cascade Communication Methods
Recruiting
Hereditary cancer programs face challenges with respect to effective communication of genetic test results within families and uptake of genetic testing by relatives. This study aims to determine if a "disclosure toolkit" provided to the index participant (carrier of cancer risk gene mutation) contributes to sharing genetic test results with relatives, if there are preferred disclosure methods, and whether toolkit use contributes towards at-risk relatives pursuing genetic testing.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2023
Locations: Abramson Cancer Center, Philadelphia, Pennsylvania
Conditions: BRCA1 Mutation, BRCA2 Mutation
Evaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode
Recruiting
The ECLIPSE (Evaluation of the ctDNA LUNAR test in an Average Patient Screening Episode) study is a prospective, observational multi-site study without randomization. The primary objective of the study is to evaluate the performance characteristics of a blood-based ctDNA LUNAR-2 test to detect colorectal cancer in a screen-relevant, average risk population.
Gender:
All
Ages:
Between 45 years and 84 years
Trial Updated:
04/04/2023
Locations: Eastern Pennsylvania GI & Liver Specialists, Allentown, Pennsylvania
Conditions: Colorectal Cancer
Organ Preservation in Early Rectal Cancer Patients
Recruiting
This is a single arm phase II study of neoadjuvant chemotherapy followed by local excision and post-operative chemoradiotherapy in patients with early stage, low rectal adenocarcinoma. After completion of pre-treatment tests/procedures (including pelvic MRI/ERUS; MRI is mandatory at baseline and other imaging is encouraged) and confirmation of eligibility, systemic therapy with FOLFOX will be administered for 12 weeks. 2 to 4 weeks after the chemotherapy, restaging of the primary tumor will be d... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/03/2023
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Rectal Cancer
Respiratory Monitoring System Safety and Performance Study
Recruiting
The goal of this observational study is collect data to evaluate the efficacy of the RMS system in monitoring, recording, and presenting respiratory function data to the user in participants scheduled for pulmonary function testing (PFT). Participants will complete: 60 episodes of data collection with a decreased tidal volume 30 episodes of data collection with an increased tidal volume 80 episodes with normal tidal volume breathing The TSS will continuously transmit sound data to an adjacent... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/02/2023
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Pulmonary Function Test, Tidal Volume, Respiratory Rate, Ventilators, Breathing Sounds
Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression
Recruiting
This clinical study is evaluating a drug called BT7480 alone and in combination with nivolumab in participants with advanced solid tumors associated with Nectin-4 expression. The main goals of the study are to: Find the recommended dose of BT7480 that can be given safely to participants alone and in combination with nivolumab Learn about the side effects and effectiveness of BT7480 alone and in combination with nivolumab Learn about the effect BT7480 has on the body and how BT7480 is cleared b... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/30/2023
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Advanced Solid Tumor
C-myc Biomarker Study for Diabetic Foot Ulcers
Recruiting
This is a multi-center observational cohort study of patients with diabetic foot ulcers (DFU) to develop and validate potential tissue-based biomarkers that predict complete wound healing. Eligible and consented participants will begin standard of care treatment after collection of tissue specimens from the wound's edge. An additional tissue specimen is collected at 4 weeks if clinically indicated. Tissues will be tested for c-myc and phosphorylated glucocorticoid receptor (p-GR) levels using va... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/29/2023
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Diabetes, Diabetic Foot, Diabetic Foot Ulcer, Diabetic Wound
Dominantly Inherited Alzheimer Network (DIAN)
Recruiting
The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/29/2023
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Alzheimer's Disease