Pennsylvania is currently home to 3297 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Prospective Analysis of Long-Term Clinical Outcomes and 3D Spine Growth in Anterior Vertebral Body Tethering
NCT04914507
Recruiting
Anterior vertebral body tethering (AVBT) is a novel, minimally invasive, growth modulation technique that was recently approved by the FDA under a Humanitarian Device Exemption (HDE). The goal of AVBT is to control curve progression by applying compression on the convex side of the spine deformity. While there has been great initial enthusiasm about the technique as an alternate treatment option to spinal fusion for skeletally immature children with scoliosis, there is a need to better understan... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
11/14/2023
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Scoliosis Idiopathic
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Smart Textile Sensor System for Health Monitoring
NCT05473702
Recruiting
The present study will investigate a set of biomedical sensors with a wireless data communication system and evaluate the sensors' recording quality. The sensors and wearable wireless system have been approved by Food and Drug Administration (FDA) for recording Electrocardiography (ECG), Trans Thoracic Impedance (TTI), Heart Sounds and Acitigraphy. The sensors and wireless system will be used along with conventional sensor systems (as intended to be used).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2023
Locations: Nanowear R&D, State College, Pennsylvania
Conditions: Heart Disease Chronic, Pulmonary Disease, Chronic Obstructive, Blood Pressure, Heart Rhythm Disorder
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Nanowear Heart Failure Management Multi-sensor Algorithm
NCT03719079
Recruiting
The NanoSense study is a multi-center, prospective, non-randomized, observational, feasibility, non-significant risk study. The NanoSense study will enroll up to 500 subjects in up to 10 centers in order to collect data which includes at least 150 heart failure hospitalizations in participating subjects.The duration of the NanoSense study is expected to be 2 years. The study device is the Wearable Congestive Heart Failure Management System (WCHFS, also known as SimpleSENSE)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2023
Locations: Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Heart Failure
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Liposomal Bupivacaine and Transoral Robotic Surgery
NCT05862792
Recruiting
This study is for patients with oropharyngeal squamous cell carcinoma. We want to learn more about how we can optimize pain control in patients who undergo transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma. Our goal is to determine if a local anesthetic called EXPAREL® (Liposomal Bupivacaine) impacts postsurgical pain and swallow function in patients with oropharyngeal squamous cell carcinoma undergoing TORS. EXPAREL® is an FDA-approved anesthetic drug that provides long... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2023
Locations: Geisinger Medical Center, Danville, Pennsylvania
Conditions: Oropharyngeal Cancer, Dysphagia, Oropharyngeal, Post Operative Pain, Transoral Robotic Surgery
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Safety and Efficacy of Oral Administration of the Phage Cocktail, VRELysin™, In Healthy and VRE-Colonized Subjects
NCT05715619
Recruiting
The study is a first-in-human Phase 1/2a randomized, double-blind, placebo-controlled trial to assess the clinical safety and efficacy of VRELysin in healthy and VRE-colonized adults.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
10/26/2023
Locations: UPMC Presbyterian, Pittsburgh, Pennsylvania
Conditions: Vancomycin-Resistant Enterococcal Colonization
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Effect of Apollo Wearable on Long COVID-19 Symptoms.
NCT06097442
Recruiting
The purpose of this study is to examine how Apollo wearable use impacts symptoms and quality of life following long COVID.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2023
Locations: The Board of Medicine, Pittsburgh, Pennsylvania
Conditions: Post-acute Sequelae of SARS-COV-2 Infection
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Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL
NCT05082519
Recruiting
This study is for older children, adolescents, and young adults with B-cell Acute Lymphoblastic Leukemia (B-ALL). Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. Chemotherapy during the first month causes large gains in body fat in most people, even those who start chemotherapy at a healthy weight. This study is being done to find out if caloric restriction achieved by a personalized nutritional menu and exercise plan during routine chemotherapy... Read More
Gender:
ALL
Ages:
Between 10 years and 25 years
Trial Updated:
10/25/2023
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: B-cell Acute Lymphoblastic Leukemia, Obesity
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SARS-CoV-2 CTLS for Mild to Moderate COVID-19 Disease
NCT04896606
Recruiting
The 2019 Severe Acute Respiratory Syndrome (SARS) is a global pandemic secondary to a novel coronavirus - SARS-CoV-2. The reported case-fatality ratio for SARS-CoV-2 in the United States is 1.8% with a current death toll of \>300,000 and climbing.4 There is no accepted standard of care or FDA approved therapies for treatment of COVID-19. Virus specific cytotoxic T lymphocytes (CTLs) have become an important part of the treatment landscape for viral reactivation post hematopoietic and solid organ... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/24/2023
Locations: Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Covid19
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Evaluating Sublingual Dexmedetomidine For Moderate To Severe Agitation In Inpatients With Schizophrenia Or Bipolar Disorder
NCT06093451
Recruiting
An open-label, randomized, active control inpatient trial to evaluate the efficacy and tolerability of sublingual dexmedetomidine for the treatment of agitation in inpatients with schizophrenia or bipolar disorder as measured by the Positive and Negative Syndrome Scale - Excited Component (PANSS-EC) and Agitation-Calmness Evaluation Scale (ACES). Lorazepam will serve as the active control.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
10/16/2023
Locations: Temple University Episcopal Hospital, Philadelphia, Pennsylvania
Conditions: Schizophrenia Agitation, Schizo Affective Disorder, Bipolar Disorder, Dexmedetomidine
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Desara ® One Single Incision Sling 522 Study
NCT04772131
Recruiting
A post-market study to compare the safety and effectiveness of the Desara® One Single Incision Sling (SIS), when compared to that of an FDA cleared transobturator sling over a period of 36 months.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/09/2023
Locations: Center for Total Women's Health, Lansdale, Pennsylvania
Conditions: Stress Urinary Incontinence
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LUT014 for the Reduction of Dose-Limiting Acneiform Lesions Associated With EGFRI Treatment of mCRC
NCT04759664
Recruiting
The study evaluates the efficacy and safety of two strengths of LUT014 Gel topically applied once a day for 4 weeks, compared to placebo, in metastatic colorectal cancer (mCRC) patients who developed Grade 2 or non-infected Grade 3 EGFRI induced acneiform lesions
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/05/2023
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: EGFRI Induced Acneiform Lesions
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Biomarker Development for Muscular Dystrophies
NCT05019625
Recruiting
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies. The investigators are interested in finding less invasive methods that reduce the need for muscle biopsies. The purpose of this research is to learn about the possibility of detecting and measuring the activity and severity of muscular dystrophies by examining a urine sample and a blood sample, and some muscles in the arms and legs using t... Read More
Gender:
ALL
Ages:
5 years and above
Trial Updated:
10/04/2023
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Myotonic Dystrophy, Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, Facioscapulohumeral Muscular Dystrophy
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