Pennsylvania is currently home to 3293 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Optimizing Digital Health Technology Interventions to Increase Skill Acquisition and Utilization
NCT05473013
Recruiting
The purpose of this study is to identify the independent and combined effects of two types of self-monitoring and two types of micro-interventions when combined with standard cognitive behavioral treatment for bulimia nervosa (BN) and binge eating disorder (BED). The primary aims of this study are (1) to evaluate the optimal complexity of Self-Monitoring and Micro-Interventions on eating pathology (at post-treatment and at 6 and 12-month follow-ups and (2) to test the hypotheses that the optimal... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/21/2023
Locations: Drexel University, Stratton Hall, Philadelphia, Pennsylvania
Conditions: Bulimia Nervosa, Bulimia, Binge Eating, Binge-Eating Disorder
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Neoneur Feeding System Functionality in the Clinic
NCT05525091
Recruiting
Prospective data collection using the Neoneur Feeding System to demonstrate device functionality, correlation to historic data, and prepare for a more extensive phase II SBIR trial
Gender:
ALL
Ages:
Between 1 day and 10 weeks
Trial Updated:
09/13/2023
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Feeding Patterns, Feeding; Difficult, Newborn, Feeding Disorder Neonatal
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FLUME Catheter Comfort Study
NCT05785858
Recruiting
The Flume catheter is a commercially available (FDA 510(k) cleared) urethral catheter with an innovative catheter design. The traditional Foley catheter design includes a protruding tip with drainage holes. The protruding tip may contribute to patient discomfort, pain and bladder spasms. The Flume catheter is designed such that the balloon envelops the tip on inflation, thus eliminating the protruding catheter tip, while the drainage holes are inset low in the balloon, providing protection to th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/10/2023
Locations: Penn State Department of Urology, Hershey, Pennsylvania
Conditions: Urinary Catheters, Bladder Pain and Discomfort, Urine Leakage, Bladder Spasm, Chronic Urinary Catheter, Urinary Retention
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A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.
NCT05867420
Recruiting
The study is a Phase 1dose escalation study to evaluate the safety, tolerability, and pharmacokinetics of ASKG915 as a single agent in patients with selected advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/05/2023
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Advanced Solid Tumors
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Engaging Men in Weight Loss With a Game-based mHealth and Neurotraining Program
NCT05408494
Recruiting
Men in the United States have an exceptionally high prevalence of overweight and obesity, i.e., 71.3%, and 42% of men are currently attempting weight loss. However, men are dramatically underrepresented in weight loss programs. Attempts to modestly adapt standard weight loss programs have seen only minimal success. Mobile applications (mHealth apps) have attractive features, but have low male enrollment and poor efficacy as conventionally delivered. A gamified mHealth program offers the possibil... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
09/05/2023
Locations: Drexel University, Philadelphia, Pennsylvania
Conditions: Obesity, Weight Loss
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VR Headset for Pain During Pregnancy Termination
NCT06029582
Recruiting
The goal of this randomized control study is to see if virtual reality headsets (VRHS) are useful in women undergoing surgical pregnancy termination. The main questions it aims to answer are: Do VRHS decrease the pain associated with surgical pregnancy termination Participants will wear the VRHS during the surgery and take a pain survey before and after the procedure. The pain assessment will be compared to placebo headset which will be randomly assigned.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/31/2023
Locations: Allentown Women Center, Allentown, Pennsylvania
Conditions: Pregnancy Termination
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Validation of CAGIB Score for In-hospital Mortality of Cirrhotic Patients With Acute Gastrointestinal Bleeding
NCT04662918
Recruiting
Acute gastrointestinal bleeding is potentially lethal in liver cirrhosis. Accurate assessment of prognosis is critical in a timely fashion. A novel model, CAGIB score, has been developed based on our Chinese multicenter retrospective study. Now, a prospective, international multicenter, observational study will be performed to further compare the performance of CAGIB versus Child-Pugh and MELD scores for evaluating the in-hospital mortality of patients with liver cirrhosis and acute gastrointest... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/30/2023
Locations: The Wright Center for Graduate Medical Education, 501 S. Washington Avenue, Scranton, Pennsylvania
Conditions: GastroIntestinal Bleeding
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Congenital Heart Disease GEnetic NEtwork Study (CHD GENES)
NCT01196182
Recruiting
Congenital heart defects (CHD) are the most common major human birth malformation, affecting \~8 per 1,000 live births. CHD are associated with significant morbidity and mortality, and are second only to infectious diseases in contributing to the infant mortality rate. Current understanding of the etiology of pediatric cardiovascular disorders is limited. The Congenital Heart Disease GEnetic NEtwork Study (CHD GENES) is a multi-center, prospective observational cohort study. Participants will b... Read More
Gender:
ALL
Ages:
99 years and below
Trial Updated:
08/29/2023
Locations: Children's Hospital Philadelphia, Philadelphia, Pennsylvania
Conditions: Congenital Heart Defects
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A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
NCT04370587
Recruiting
This is a Phase 1/2a, open-label, study to evaluate the safety and preliminary efficacy of intratumoral T3011 given alone and in combination with intravenous pembrolizumab in partients with advanced or metastatic solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2023
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Melanoma, Solid Tumor, NSCLC, HNSCC, Sarcoma, Squamous Cell Carcinoma
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Biological Effects of Quercetin in COPD
NCT03989271
Recruiting
This study determines whether quercetin supplementation reduces the inflammation and oxidative stress markers in patients with chronic obstructive pulmonary disease. It is small study with 8 subjects receive quercetin 2000 mg/day and 4 subjects receive placebo.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
08/15/2023
Locations: Nathaniel Marchetti, Philadelphia, Pennsylvania
Conditions: Chronic Obstructive Pulmonary Disease
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Improving Infant Hydrocephalus Outcomes in Uganda
NCT03650101
Recruiting
Neonatal postinfectious hydrocephalus (PIH) is a major public health problem in East Africa.The standard treatment has long been placement of a ventriculoperitoneal shunt (VPS) but these devices require life-long maintenance and nearly all fail multiple times. Endoscopic Third Ventriculostomy (ETV) with Choroid Plexus Cauterization (ETV/CPC) is an alternate treatment to give patients a shunt-free life. In this study, the investigators aim to optimize the metrics of evaluation as quantitative pro... Read More
Gender:
ALL
Ages:
Between 1 day and 180 days
Trial Updated:
08/09/2023
Locations: Penn State University, University Park, Pennsylvania
Conditions: Hydrocephalus
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The Effect of Guided Care With Vectra Compared to Treatment as Usual in Patients With Rheumatoid Arthritis
NCT03631225
Recruiting
The goal of treating patients diagnosed with rheumatoid arthritis (RA) is to achieve remission or low disease activity and thereby prevent joint damage, loss of physical function, and disability. Optimal management requires regular assessment of disease activity, with treatment changes made as needed for optimal efficacy. Vectra is a blood serum test that looks at 12 biomarkers and produces a score on a scale of 1 to 100. The Vectra score has been shown to be the strongest predictor of risk for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: East Penn Rheumatology Associates, P.C., Bethlehem, Pennsylvania
Conditions: Rheumatoid Arthritis (RA)
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