Pennsylvania is currently home to 3304 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Biomarker Development for Muscular Dystrophies
NCT05019625
Recruiting
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies. The investigators are interested in finding less invasive methods that reduce the need for muscle biopsies. The purpose of this research is to learn about the possibility of detecting and measuring the activity and severity of muscular dystrophies by examining a urine sample and a blood sample, and some muscles in the arms and legs using t... Read More
Gender:
ALL
Ages:
5 years and above
Trial Updated:
10/04/2023
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Myotonic Dystrophy, Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, Facioscapulohumeral Muscular Dystrophy
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Project PEAK: Early Intervention for ADHD
NCT04627415
Recruiting
Parent education is an effective and relatively cost efficient approach for reducing child behavior problems. Research, however, suggests that the effectiveness of parent education is mitigated by parent attendance and parent implementation of intervention strategies. That is, low attendance at parent education sessions is associated with limited intervention effects. Therefore, it is critical to identify strategies to enhance parent engagement. A previous pilot randomized controlled trial of a... Read More
Gender:
ALL
Ages:
Between 3 years and 5 years
Trial Updated:
10/03/2023
Locations: Lehigh University, Bethlehem, Pennsylvania
Conditions: Attention Deficit Hyperactivity Disorder, Parent-Child Relations, Child Behavior, Parenting
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Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal Syndrome
NCT05875948
Recruiting
This study aims to evaluate the safety, tolerability and efficacy of R2R01 combined with terlipressin as compared to terlipressin alone in the treatment of patients with HRS-AKI
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/29/2023
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Hepatorenal Syndrome, Acute Kidney Injury
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ImPACT Normative Extension
NCT03180905
Recruiting
The researchers want to find out more about a standalone software application, ImPACT Online and how it relates to other commonly used tests of memory, attention and reaction time. ImPACT Online is a computer-based neurocognitive test for concussion management. The test was designed to help measure the effects of concussion on cognitive processes (for example, memory, attention, brain speed) and visual functioning.
Gender:
ALL
Ages:
Between 60 years and 80 years
Trial Updated:
09/27/2023
Locations: ImPACT Applications Inc., Pittsburgh, Pennsylvania
Conditions: Brain Concussion
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The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
NCT04075305
Recruiting
The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further technical development of the MR-Linac system with the ultimate purpose to improve patients' survival, local, and regional tumor control and quality of life.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2023
Locations: Allegheny Health Network, Pittsburgh, Pennsylvania
Conditions: Oncology, Breast Cancer, Prostate Cancer, Gynecologic Cancer, Brain Tumor, Brain Cancer, Gynecologic Tumor, Prostate Tumor, Prostate Neoplasm, Breast Tumor, Radiation Toxicity, Quality of Life, Rectal Cancer, Rectal Tumor, Rectal Neoplasms, Lung Cancer, Lung Tumor, Lung Neoplasm, Esophageal Cancer, Esophagus Cancer, Esophageal Tumor, Esophageal Neoplasm, Esophagus Tumor, Esophagus Neoplasm, Pancreatic Cancer, Pancreatic Tumor, Pancreatic Neoplasms, Head and Neck Cancer, Head and Neck Neoplasms, Head and Neck Tumor, Tumor, Neoplasms, Bladder Cancer, Bladder Neoplasm, Liver Cancer, Liver Neoplasms, Liver Metastases, Oligometastases
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Optimizing Digital Health Technology Interventions to Increase Skill Acquisition and Utilization
NCT05473013
Recruiting
The purpose of this study is to identify the independent and combined effects of two types of self-monitoring and two types of micro-interventions when combined with standard cognitive behavioral treatment for bulimia nervosa (BN) and binge eating disorder (BED). The primary aims of this study are (1) to evaluate the optimal complexity of Self-Monitoring and Micro-Interventions on eating pathology (at post-treatment and at 6 and 12-month follow-ups and (2) to test the hypotheses that the optimal... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/21/2023
Locations: Drexel University, Stratton Hall, Philadelphia, Pennsylvania
Conditions: Bulimia Nervosa, Bulimia, Binge Eating, Binge-Eating Disorder
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Neoneur Feeding System Functionality in the Clinic
NCT05525091
Recruiting
Prospective data collection using the Neoneur Feeding System to demonstrate device functionality, correlation to historic data, and prepare for a more extensive phase II SBIR trial
Gender:
ALL
Ages:
Between 1 day and 10 weeks
Trial Updated:
09/13/2023
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Feeding Patterns, Feeding; Difficult, Newborn, Feeding Disorder Neonatal
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FLUME Catheter Comfort Study
NCT05785858
Recruiting
The Flume catheter is a commercially available (FDA 510(k) cleared) urethral catheter with an innovative catheter design. The traditional Foley catheter design includes a protruding tip with drainage holes. The protruding tip may contribute to patient discomfort, pain and bladder spasms. The Flume catheter is designed such that the balloon envelops the tip on inflation, thus eliminating the protruding catheter tip, while the drainage holes are inset low in the balloon, providing protection to th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/10/2023
Locations: Penn State Department of Urology, Hershey, Pennsylvania
Conditions: Urinary Catheters, Bladder Pain and Discomfort, Urine Leakage, Bladder Spasm, Chronic Urinary Catheter, Urinary Retention
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Prevalence of Multidrug Resistant Micro-organism Carriage in Patients Undergoing an ERCP in Four Different Countries
NCT05303662
Recruiting
The duodenoscopes currently used for Endoscopic Retrograde Cholangio - and Pancreaticography (ERCP) examinations are reusable and are therefore washed and disinfected after each use. Despite this, these endoscopes sometimes remain contaminated with bacteria. Several reports of outbreaks linked to contaminated duodenoscopes have been published worldwide. Recently, the Food and Drug Administration (FDA) advised manufacturers and health care professionals to transition away from fixed endcap duoden... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/06/2023
Locations: UPMC, Pittsburgh, Pennsylvania
Conditions: Drug Resistance, Multiple, Bacterial, Cholangiopancreatography, Endoscopic Retrograde
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A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.
NCT05867420
Recruiting
The study is a Phase 1dose escalation study to evaluate the safety, tolerability, and pharmacokinetics of ASKG915 as a single agent in patients with selected advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/05/2023
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Advanced Solid Tumors
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Engaging Men in Weight Loss With a Game-based mHealth and Neurotraining Program
NCT05408494
Recruiting
Men in the United States have an exceptionally high prevalence of overweight and obesity, i.e., 71.3%, and 42% of men are currently attempting weight loss. However, men are dramatically underrepresented in weight loss programs. Attempts to modestly adapt standard weight loss programs have seen only minimal success. Mobile applications (mHealth apps) have attractive features, but have low male enrollment and poor efficacy as conventionally delivered. A gamified mHealth program offers the possibil... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
09/05/2023
Locations: Drexel University, Philadelphia, Pennsylvania
Conditions: Obesity, Weight Loss
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VR Headset for Pain During Pregnancy Termination
NCT06029582
Recruiting
The goal of this randomized control study is to see if virtual reality headsets (VRHS) are useful in women undergoing surgical pregnancy termination. The main questions it aims to answer are: Do VRHS decrease the pain associated with surgical pregnancy termination Participants will wear the VRHS during the surgery and take a pain survey before and after the procedure. The pain assessment will be compared to placebo headset which will be randomly assigned.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/31/2023
Locations: Allentown Women Center, Allentown, Pennsylvania
Conditions: Pregnancy Termination
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