Pennsylvania is currently home to 3305 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
NCT04075305
Recruiting
The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further technical development of the MR-Linac system with the ultimate purpose to improve patients' survival, local, and regional tumor control and quality of life.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2023
Locations: Allegheny Health Network, Pittsburgh, Pennsylvania
Conditions: Oncology, Breast Cancer, Prostate Cancer, Gynecologic Cancer, Brain Tumor, Brain Cancer, Gynecologic Tumor, Prostate Tumor, Prostate Neoplasm, Breast Tumor, Radiation Toxicity, Quality of Life, Rectal Cancer, Rectal Tumor, Rectal Neoplasms, Lung Cancer, Lung Tumor, Lung Neoplasm, Esophageal Cancer, Esophagus Cancer, Esophageal Tumor, Esophageal Neoplasm, Esophagus Tumor, Esophagus Neoplasm, Pancreatic Cancer, Pancreatic Tumor, Pancreatic Neoplasms, Head and Neck Cancer, Head and Neck Neoplasms, Head and Neck Tumor, Tumor, Neoplasms, Bladder Cancer, Bladder Neoplasm, Liver Cancer, Liver Neoplasms, Liver Metastases, Oligometastases
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Optimizing Digital Health Technology Interventions to Increase Skill Acquisition and Utilization
NCT05473013
Recruiting
The purpose of this study is to identify the independent and combined effects of two types of self-monitoring and two types of micro-interventions when combined with standard cognitive behavioral treatment for bulimia nervosa (BN) and binge eating disorder (BED). The primary aims of this study are (1) to evaluate the optimal complexity of Self-Monitoring and Micro-Interventions on eating pathology (at post-treatment and at 6 and 12-month follow-ups and (2) to test the hypotheses that the optimal... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/21/2023
Locations: Drexel University, Stratton Hall, Philadelphia, Pennsylvania
Conditions: Bulimia Nervosa, Bulimia, Binge Eating, Binge-Eating Disorder
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Information Seeking About Pre-exposure Prophylaxis
NCT05728034
Recruiting
The goal of these two intervention studies is to test promising health communication messaging strategies most likely to enhance Black, Hispanic, and non-Hispanic White YMSM's (young men who have sex with men's) engagement with online content about injectable and oral PrEP (pre-exposure prophylaxis). Participants will be asked to browse a mock Google results page featuring various kinds of PrEP information, and their browsing behavior will be unobtrusively logged. In Study 1, participants will b... Read More
Gender:
MALE
Ages:
Between 18 years and 34 years
Trial Updated:
09/19/2023
Locations: Pennsylvania State University, University Park, Pennsylvania
Conditions: Pre-exposure Prophylaxis
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Neoneur Feeding System Functionality in the Clinic
NCT05525091
Recruiting
Prospective data collection using the Neoneur Feeding System to demonstrate device functionality, correlation to historic data, and prepare for a more extensive phase II SBIR trial
Gender:
ALL
Ages:
Between 1 day and 10 weeks
Trial Updated:
09/13/2023
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Feeding Patterns, Feeding; Difficult, Newborn, Feeding Disorder Neonatal
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FLUME Catheter Comfort Study
NCT05785858
Recruiting
The Flume catheter is a commercially available (FDA 510(k) cleared) urethral catheter with an innovative catheter design. The traditional Foley catheter design includes a protruding tip with drainage holes. The protruding tip may contribute to patient discomfort, pain and bladder spasms. The Flume catheter is designed such that the balloon envelops the tip on inflation, thus eliminating the protruding catheter tip, while the drainage holes are inset low in the balloon, providing protection to th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/10/2023
Locations: Penn State Department of Urology, Hershey, Pennsylvania
Conditions: Urinary Catheters, Bladder Pain and Discomfort, Urine Leakage, Bladder Spasm, Chronic Urinary Catheter, Urinary Retention
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Prevalence of Multidrug Resistant Micro-organism Carriage in Patients Undergoing an ERCP in Four Different Countries
NCT05303662
Recruiting
The duodenoscopes currently used for Endoscopic Retrograde Cholangio - and Pancreaticography (ERCP) examinations are reusable and are therefore washed and disinfected after each use. Despite this, these endoscopes sometimes remain contaminated with bacteria. Several reports of outbreaks linked to contaminated duodenoscopes have been published worldwide. Recently, the Food and Drug Administration (FDA) advised manufacturers and health care professionals to transition away from fixed endcap duoden... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/06/2023
Locations: UPMC, Pittsburgh, Pennsylvania
Conditions: Drug Resistance, Multiple, Bacterial, Cholangiopancreatography, Endoscopic Retrograde
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A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.
NCT05867420
Recruiting
The study is a Phase 1dose escalation study to evaluate the safety, tolerability, and pharmacokinetics of ASKG915 as a single agent in patients with selected advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/05/2023
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Advanced Solid Tumors
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Engaging Men in Weight Loss With a Game-based mHealth and Neurotraining Program
NCT05408494
Recruiting
Men in the United States have an exceptionally high prevalence of overweight and obesity, i.e., 71.3%, and 42% of men are currently attempting weight loss. However, men are dramatically underrepresented in weight loss programs. Attempts to modestly adapt standard weight loss programs have seen only minimal success. Mobile applications (mHealth apps) have attractive features, but have low male enrollment and poor efficacy as conventionally delivered. A gamified mHealth program offers the possibil... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
09/05/2023
Locations: Drexel University, Philadelphia, Pennsylvania
Conditions: Obesity, Weight Loss
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VR Headset for Pain During Pregnancy Termination
NCT06029582
Recruiting
The goal of this randomized control study is to see if virtual reality headsets (VRHS) are useful in women undergoing surgical pregnancy termination. The main questions it aims to answer are: Do VRHS decrease the pain associated with surgical pregnancy termination Participants will wear the VRHS during the surgery and take a pain survey before and after the procedure. The pain assessment will be compared to placebo headset which will be randomly assigned.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/31/2023
Locations: Allentown Women Center, Allentown, Pennsylvania
Conditions: Pregnancy Termination
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Validation of CAGIB Score for In-hospital Mortality of Cirrhotic Patients With Acute Gastrointestinal Bleeding
NCT04662918
Recruiting
Acute gastrointestinal bleeding is potentially lethal in liver cirrhosis. Accurate assessment of prognosis is critical in a timely fashion. A novel model, CAGIB score, has been developed based on our Chinese multicenter retrospective study. Now, a prospective, international multicenter, observational study will be performed to further compare the performance of CAGIB versus Child-Pugh and MELD scores for evaluating the in-hospital mortality of patients with liver cirrhosis and acute gastrointest... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/30/2023
Locations: The Wright Center for Graduate Medical Education, 501 S. Washington Avenue, Scranton, Pennsylvania
Conditions: GastroIntestinal Bleeding
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Congenital Heart Disease GEnetic NEtwork Study (CHD GENES)
NCT01196182
Recruiting
Congenital heart defects (CHD) are the most common major human birth malformation, affecting \~8 per 1,000 live births. CHD are associated with significant morbidity and mortality, and are second only to infectious diseases in contributing to the infant mortality rate. Current understanding of the etiology of pediatric cardiovascular disorders is limited. The Congenital Heart Disease GEnetic NEtwork Study (CHD GENES) is a multi-center, prospective observational cohort study. Participants will b... Read More
Gender:
ALL
Ages:
99 years and below
Trial Updated:
08/29/2023
Locations: Children's Hospital Philadelphia, Philadelphia, Pennsylvania
Conditions: Congenital Heart Defects
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A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
NCT04370587
Recruiting
This is a Phase 1/2a, open-label, study to evaluate the safety and preliminary efficacy of intratumoral T3011 given alone and in combination with intravenous pembrolizumab in partients with advanced or metastatic solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2023
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Melanoma, Solid Tumor, NSCLC, HNSCC, Sarcoma, Squamous Cell Carcinoma
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