Pennsylvania is currently home to 3304 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study
NCT03726307
Recruiting
This study will evaluate the safety and feasibility of treatment involving a single infusion of donor-derived regulatory dendritic cells (DCreg) in first time, living donor renal transplant recipients. DCreg will be prepared from monocytes obtained by leukapheresis from prospective (non-mobilized) living kidney donors and infused into the respective recipients 7 days before renal transplantation. This study will enroll 28 subjects (14 recipients, 14 donors). The duration of follow-up will be:... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/13/2023
Locations: University of Pittsburgh, Starzl Transplantation Institute, Pittsburgh, Pennsylvania
Conditions: Kidney Transplant, Renal Transplant Recipients
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A Clinical Trial of KVA12123 Treatment Alone and in Combination With Pembrolizumab In Advanced Solid Tumors (VISTA-101)
NCT05708950
Recruiting
The goal of this clinical trial is to test the safety and efficacy of KVA12123 alone or combined with pembrolizumab in patients with advanced solid tumors. The main questions this study aims to answer are: 1. What is the safety of KVA12123 when administered alone and in combination with pembrolizumab to advanced cancer patients? 2. What is an appropriate dose of KVA12123 to administer alone and in combination with pembrolizumab to advanced cancer patients in future clinical trials? Participant... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2023
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Cancer, Solid Tumor, Melanoma, Carcinoma, Sarcoma, Lung Cancer, Prostate Cancer, Breast Cancer, Colo-rectal Cancer, Uterine Cancer, Pancreatic Cancer, Gastric Cancer, Esophageal Cancer, Thyroid Cancer, Ovarian Cancer, Kidney Cancer, Head and Neck Cancer
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Buprenorphine for Cancer Pain
NCT05910190
Recruiting
This study will evaluate patients on both buprenorphine and full agonist opioids (FAO) to assess for withdrawal symptoms. Patients will be evaluated by clinicians and using validated tools to assess for pain and withdrawal. At the same time, patients will use a CPM Rx application on their phone to track medication use.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/06/2023
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Cancer-Related Pain
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Wells and Enteric Disease Transmission
NCT04826991
Recruiting
Approximately 40 million people in the US are served by private, and frequently untreated, wells. Our best estimate is that 1.3 million cases of gastrointestinal illnesses (GI) per year are attributed to consuming water from untreated private wells in the US, but in reality, there are no robust epidemiological data that can be used to estimate cases of GI attributable to these sources. We propose the first randomized controlled trial (RCT) to estimate the burden of GI associated with private wel... Read More
Gender:
ALL
Ages:
Between 6 months and 59 months
Trial Updated:
06/30/2023
Locations: Temple University, Philadelphia, Pennsylvania
Conditions: Diarrhea, Gastrointestinal Infection, Respiratory Viral Infection, Waterborne Diseases
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Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study
NCT03911492
Recruiting
This multicenter study will enroll 100 patients with acute traumatic cervical and thoracic SCI who have a lumbar intrathecal catheter inserted within 24 hours of their injury. The lumbar intrathecal catheter will be inserted pre-operatively for the measurement of ITP and the collection of cerebrospinal fluid (CSF) samples. SCPP will be calculated as the difference between MAP and the ITP. There are two important distinct yet related objectives in this prospective interventional study. 1. Deter... Read More
Gender:
ALL
Ages:
17 years and above
Trial Updated:
06/30/2023
Locations: University Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Acute Spinal Cord Injury, Acute Spinal Paralysis, Spinal Cord Injuries, SPINAL Fracture
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Electromagnetic Fields Versus Placebo For Child-Pugh A and B Patients With Advanced Hepatocellular Carcinoma
NCT04797884
Recruiting
The primary goals of this study are to compare overall survival and quality of life in subjects with Child-Pugh A or B advanced hepatocellular carcinoma when treated with a device emitting radiofrequencies modulated at specific frequencies or with a device emitting unmodulated radiofrequencies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2023
Locations: Thomas Jefferson University Hospital, Sidney Kimmel Cancer Center, Philadelphia, Pennsylvania
Conditions: Hepatocellular Carcinoma
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Forging Sustainable Solutions for HIV Continuity of Care Through Medical-legal Partnerships
NCT05912842
Recruiting
The goal of this study is to test the Organizational Partnerships for Healthy Living (OPAHL) intervention through a feasibility and acceptability trial. OPAHL is an innovative, multilevel intervention package intended for health care organizations serving people living with HIV (PLWH). It was developed through a prior study (grant #: R21 MH115820) using intervention mapping methodology and community-scientific collaborative boards. OPAHL consists of: 1) training (7/8hours) for all MLP staff (cli... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/21/2023
Locations: TPAC, Philadelphia, Pennsylvania
Conditions: Organizational Partnerships for Healthy Living, Standard of Care
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Influence of Cognition on Activity and Participation in People With Stroke
NCT05919251
Recruiting
If a subject agrees to participate, the primary investigators will collect some basic information including age, height, and weight. Intake of some general questions regarding health will be performed and each subject will complete some tests that measure walking speed, cognition, and balance. During these tests participants will be asked to stand from a chair, walk up \& down a staircase, walk over objects in a forward, backward, and sideways directions, walk around objects in forward and backw... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/15/2023
Locations: Saint Joseph's University, Philadelphia, Pennsylvania
Conditions: Stroke, Cognitive Change, Neurological Injury, Cognitive Impairment, Activity, Motor
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Glioma Supra Marginal Incision Trial
NCT04737577
Recruiting
G-SUMIT is a pilot, phase II,randomized controlled trial to evaluate the feasibility of performing a large-scale trial in patients undergoing surgery for first-time diagnosis of high grade glioma (HGG) in a surgically favorable anatomical location to answer the following: Does extending the margin of resection 1 cm beyond visible enhanced volume on MRI result in (a) an increase in overall survival? (b) result in a similar rate of "clinically-significant" neurological worsening during 30 days po... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
06/15/2023
Locations: The Pennsylvania State University, University Park, Pennsylvania
Conditions: High Grade Glioma
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Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study
NCT05291884
Recruiting
This is a prospective, multi-center, single-arm, early feasibility study that aims to evaluate the safety of the Impella BTR™ in adult patients requiring left-ventricular hemodynamic support, and to evaluate the effectiveness of the Impella BTR™ in supporting patients to recovery or their next therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/07/2023
Locations: Allegheny General Hospital, Pittsburgh, Pennsylvania
Conditions: Heart Failure, Acute Decompensated Heart Failure
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AMP SCZ® Observational Study: PREDICT-DPACC
NCT05905003
Recruiting
The Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) is a large international collaboration to develop algorithms using a set of clinical and cognitive assessments, multi-modal biomarkers, and clinical endpoints that can be used to predict the trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the testing of pharmacological interventions for CHR individuals in need. The goal is to accurately predict which individuals are likely to remit,... Read More
Gender:
ALL
Ages:
Between 12 years and 30 years
Trial Updated:
06/06/2023
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Clinical High Risk, Psychosis, Remission, Conversion
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SBRT +/- Pembrolizumab in Patients With Local-Regionally Recurrent or Second Primary Head and Neck Carcinoma
NCT03546582
Recruiting
This phase II trial with a safety run-in component will evaluate whether the addition of pembrolizumab to Stereotactic Body Radiation Therapy (SBRT) re-irradiation will improve the progression-free survival for patients with recurrent or new second primary Head and Neck Squamous Cell Carcinoma (HNSCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/01/2023
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC)
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