Tennessee is currently home to 1982 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Nashville, Memphis, Knoxville and Chattanooga. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Ruxolitinib for Premalignant Breast Disease
NCT02928978
Recruiting
This study is evaluating how ruxolitinib affects premalignant breast cells. One half of the study participants will receive ruxolitinib for approximately 15 days, and the other half will receive a placebo (sugar pill) for approximately 15 days. Once study participants have completed their ruxolitinib or placebo, participants will undergo surgery to remove the premalignant breast tissue.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/09/2022
Locations: Vanderbilt-Ingram Cancer Center, Nashville, Tennessee
Conditions: Ductal Carcinoma In Situ, Atypical Lobular Hyperplasia, Atypical Ductal Hyperplasia, Lobular Carcinoma In Situ
Register for Updates
Clary Sage Essential Oil & Pregnancy
NCT05000424
Recruiting
The purpose of this study is to evaluate the potential for clary sage essential oil to support overall health, wellbeing, and quality of life during the third trimester of pregnancy among otherwise healthy adult women.
Gender:
Female
Ages:
Between 20 years and 39 years
Trial Updated:
04/29/2022
Locations: Franklin Health Research Center, Franklin, Tennessee
Conditions: Quality of Life, Pregnancy Related
Register for Updates
The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest
NCT03079414
Recruiting
Sudden cardiac death (SCD) remains a major cause of mortality within developed nations despite aggressive efforts to reduce its societal burden. Despite extensive clinical and genetic investigations, a subgroup of cardiac arrests remain unexplained, highlighting the potential contribution of additional cardiac conditions that may not be identified with contemporary diagnostic algorithms. The EPS ARREST study aims to evaluate the role of invasive electrophysiology study within this patient popula... Read More
Gender:
All
Ages:
All
Trial Updated:
04/29/2022
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Sudden Cardiac Death
Register for Updates
SYNCHRONISE: LVO Triage Timing and Outcome Study
NCT04608617
Recruiting
The objective of this study is to evaluate the impact of Viz LVO in hospital systems with non-interventional and interventional (spoke and hub) stroke centers on the timing and outcomes of patients with suspected acute ischemic stroke indicated for mechanical thrombectomy.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/26/2022
Locations: Semmes-Murphey, Memphis, Tennessee
Conditions: Stroke, Ischemic
Register for Updates
Preventing Acute Kidney Injury (AKI) in Pediatric Patients
NCT03897335
Recruiting
The purpose of this study is to compare the effects of peri-operative administration of Aminophylline versus Saline placebo in the preservation of renal function and the attenuation of renal injury in pediatric patients undergoing open heart surgery.
Gender:
All
Ages:
18 years and below
Trial Updated:
04/11/2022
Locations: LeBonheur Children's Hospital, Memphis, Tennessee
Conditions: Acute Kidney Injury
Register for Updates
Descartes-08 Consolidation Treatment in Patients With High-Risk Multiple Myeloma Who Have Residual Disease After Induction Therapy
NCT04816526
Recruiting
To assess Minimal Residual Disease (MRD)-negative Complete Response (sCR) rate after consolidation treatment with Descartes-08 in patients with high-risk myeloma who have residual disease following induction therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2022
Locations: Sarah Cannon Research Institute at Tennessee Oncology, Nashville, Tennessee
Conditions: Myeloma Multiple
Register for Updates
Real-Time Muscle Pressure Measurements in Patients at Risk for Acute Compartment Syndrome
NCT04671173
Recruiting
The purpose of this trial is to conduct a pilot study that will aid in the design of an evaluation of the clinical benefit of MY01, an FDA cleared device, that allows continuous monitoring of intracompartmental muscle pressure in patients at risk for developing acute compartment syndrome. MY01 has previously been successfully tested on animal and Human cadaver Acute Compartment Syndrome models within the RI MUHC through Department of Defense research Grant (Combat Casualty Care Research Program... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/04/2022
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Acute Compartment Syndrome
Register for Updates
Study to Evaluate Effects of INL1 in Patients With Heart Failure and Reduced Ejection Fraction
NCT03875183
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled, dose-response trial in patients with chronic stable Heart Failure (HF) and reduced Left Ventricular Ejection Fraction (LVEF) to evaluate the efficacy and safety of three INL1 doses compared with placebo. Patients will be treated for approximately 12 weeks with one of three INL1 doses: 50 mg, 150 mg, 300 mg, or, placebo capsules, taken twice daily (BID).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
03/28/2022
Locations: Stern Cardiovascular, Germantown, Tennessee
Conditions: Heart Failure, Reduced Ejection Fraction
Register for Updates
A First-in-Human, Phase 1 Study of JAB-3312 in Adult Patients With Advanced Solid Tumors
NCT04045496
Recruiting
This is a Phase 1, first-in-human, open-label dose-escalation study to determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) and assess the DLT of JAB-3312. It is anticipated that approximately 24 subjects will be enrolled in the dose-escalation phase of the study. JAB-3312 will be administered orally once daily (QD) in 21-day treatment cycles.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/13/2022
Locations: Tennessee Oncology, PLLC, Nashville, Tennessee
Conditions: Non-small Cell Lung Cancer, Colorectal Cancer, Pancreatic Ductal Carcinoma, Esophageal Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma, Breast Cancer, Other Solid Tumors
Register for Updates
A First-in-Human Study of JAB-8263 in Adult Patients With Advanced Solid Tumors
NCT04587479
Recruiting
This is a Phase 1, first-in-human, open-label study of JAB-8263 to determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D) and assess the DLT. 30 subjects with advanced solid tumor will be enrolled.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/11/2022
Locations: Tennessee Oncology Nashville, Nashville, Tennessee
Conditions: Solid Tumors, Adult
Register for Updates
Finding the Cause for Post-Transplant Diabetes Mellitus After Allogeneic Hematopoietic Cell Transplant
NCT03415139
Recruiting
This clinical research studies the physiology and immunology of new-onset post-transplant diabetes mellitus in patients undergoing allogeneic stem cell transplantation. Oral glucose tolerance tests (OGTT), hyperglycemic clamps, and immune assays will be used to define the mechanisms associated with abnormal glucose homeostasis following stem cell transplantation. Information from this clinical trial could be used to develop standardized screening procedures or to develop optimal treatment strate... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
03/10/2022
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Diabetes Mellitus, Cancer
Register for Updates
Ruptured Aneurysms Treated With Hydrogel Coils
NCT03252314
Recruiting
To determine safety and occlusion rates when second-generation hydrogel coils are used in the treatment of ruptured intracranial aneurysms.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/08/2022
Locations: Methodist University Hospital, Memphis, Tennessee
Conditions: Ruptured Aneurysm
Register for Updates