Virginia is currently home to 1868 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)
NCT05263934
Recruiting
This study aims to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory EGPA receiving SoC therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/06/2023
Locations: GSK Investigational Site, Norfolk, Virginia
Conditions: Eosinophilic Granulomatosis With Polyangiitis
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GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
NCT03821129
Recruiting
This study will assess the safety and effectiveness of GORE® CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
11/06/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Stroke, PFO - Patent Foramen Ovale
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Safety and Efficacy of Tideglusib in Congenital or Childhood Onset Myotonic Dystrophy
NCT05004129
Recruiting
This is an open-label phase 2/3 study for individuals with Congenital Myotonic Dystrophy (Congenital DM1) who participated in the preceding AMO-02-MD-2-003 study or individuals with either Congenital or Childhood Onset DM1 who are treatment naïve.
Gender:
All
Ages:
Between 6 years and 45 years
Trial Updated:
11/05/2023
Locations: Children's Hospital of The King's Daughters, Norfolk, Virginia
Conditions: Congenital Myotonic Dystrophy
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Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes
NCT05478707
Recruiting
The investigators will test the hypothesis that, in adults with type 1 diabetes (T1D), glucagon-like peptide-1 receptor agonism (GLP-1RA, i.e. dulaglutide) and exercise training each enhance insulin-mediated skeletal muscle microvascular perfusion via attenuating endothelial oxidative stress and thereby improving endothelial function.
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
11/03/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Diabetes Mellitus, Type 1, Endothelial Dysfunction
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Interleukin-1 Blockade for Treatment of Cardiac Sarcoidosis
NCT04017936
Recruiting
Sarcoidosis is a heterogeneous disorder of unknown etiology whose signature lesions are granulomatous inflammatory infiltrates in involved tissues. Tissue commonly affected are lungs, skin, eyes, lymph nodes and the heart. In this latter case, cardiac sarcoidosis (CS) can lead to atrioventricular (AV) blocks, ventricular arrhythmias, heart failure (HF) and sudden cardiac death. Similar to other involved organs, cardiac disease generally progresses from areas of focal inflammation to scar. Howeve... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
11/02/2023
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Cardiac Sarcoidosis
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A Study to Assess the Efficacy and Safety of HMI-115 in Subjects With Endometriosis-Associated Pain
NCT05101317
Recruiting
This study is designed to evaluate the safety and efficacy of HMI-115 compared to placebo over a 12 weeks period on subjects with moderate to severe endometriosis-associated pain.
Gender:
Female
Ages:
Between 18 years and 49 years
Trial Updated:
11/01/2023
Locations: Tidewater Clinical Research/TPW, Norfolk, Virginia
Conditions: Endometriosis
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Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion
NCT04597099
Recruiting
This study is trying to find out if flutamide (a medication that blocks the effects of testosterone) may help normalize an aspect of pituitary function (specifically, gonadotropin surge generation) in PCOS. This is a randomized, placebo-controlled, double-blinded, crossover study. The investigators hypothesize that in estradiol-pretreated women with PCOS, acute progesterone augmentation of FSH release (positive feedback) will be enhanced by flutamide.
Gender:
Female
Ages:
Between 18 years and 30 years
Trial Updated:
11/01/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: PCOS, Polycystic Ovary Syndrome
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Relative Desirability of Metformin vs. Birth Control Pill in Treating PCOS in Women of Later Reproductive Age
NCT03905941
Recruiting
The goal of this study is to determine the relative desirability of metformin vs. oral combined hormonal contraceptives (OCs) in treating Polycystic Ovary Syndrome (PCOS) in women of later reproductive age. Polycystic Ovary Syndrome Questionnaire (PCOSQ) score will be used as a proxy for patient satisfaction. In light of their respective effects on the classic and metabolic facets of PCOS, metformin will provide non-inferior patient satisfaction compared to OCs in later reproductive age women wi... Read More
Gender:
Female
Ages:
Between 40 years and 49 years
Trial Updated:
11/01/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome
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Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS
NCT03905603
Recruiting
The objective of the study is to determine the relative contributions of four established predictors of hyperandrogenism (luteinizing hormone [LH] secretion, ovarian response to recombinant human chorionic gonadotropin [r-hCG] administration, adrenal response to adrenocorticotropic hormone [ACTH] administration, and hyperinsulinemia) in older vs. young women with Polycystic Ovary Syndrome (PCOS) in a cross-sectional, physiological study. The investigators hypothesize that hyperinsulinemia is a s... Read More
Gender:
Female
Ages:
Between 20 years and 49 years
Trial Updated:
11/01/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome
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Study to Assess Potential Impairments in Estradiol Augmentation of Gonadotropin Secretion in Polycystic Ovary Syndrome
NCT03401047
Recruiting
The purpose of this study is to determine if estradiol augmentation of luteinizing hormone (LH) secretion secretion (primary endpoint) and follicle-stimulating hormone (FSH) secretion (secondary endpoint) is reduced in adult women with polycystic ovary syndrome.
Gender:
Female
Ages:
Between 18 years and 30 years
Trial Updated:
11/01/2023
Locations: University of Virginia Clinical Research Unit, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome
Register for Updates
Hyperandrogenemia and Altered Day-night LH Pulse Patterns
NCT03068910
Recruiting
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely reduce waking luteinizing hormone pulse frequency (primary endpoint).
Gender:
Female
Ages:
Between 10 years and 17 years
Trial Updated:
11/01/2023
Locations: University of Virginia Clinical Research Unit, Charlottesville, Virginia
Conditions: Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
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Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy
NCT02984761
Recruiting
Patients with stage I non-small cell lung cancer have been historically treated with surgery whenever they are fit for an operation. However, an alternative treatment known as stereotactic radiotherapy now appears to offer an equally effective alternative. Doctors believe both are good treatments and are therefore conducting this study to determine if one may be possibly better than the other.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/01/2023
Locations: Hunter Holmes McGuire VA Medical Center, Richmond, VA, Richmond, Virginia
Conditions: Lung Neoplasm
Register for Updates