Virginia is currently home to 1881 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
NCT05561387
Recruiting
This phase III trial compares three-drug induction regimens followed by double-or single-drug maintenance therapy for the treatment of newly diagnosed multiple myeloma in patients who are not receiving a stem cell transplant and are considered frail or intermediate-fit based on age, comorbidities, and functional status. Treatment for multiple myeloma includes initial treatment (induction) which is the first treatment a patient receives for cancer followed by ongoing treatment (maintenance) which... Read More
Gender:
All
Ages:
All
Trial Updated:
10/24/2023
Locations: Sovah Health Martinsville, Martinsville, Virginia
Conditions: Plasma Cell Myeloma
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A Study of the Safety and PK of PCS6422 (Eniluracil) With Capecitabine in Patients With Advanced, Refractory GI Tract Tumors
NCT04861987
Recruiting
This study is an open label, multicenter study in patients who have advanced, relapsed refractory GI cancer or are not relapsed/refractory but are intolerant to other therapies who, in the judgment of investigators, are candidates for fluoropyrimidine monotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/24/2023
Locations: Processa Clinical Site, Fairfax, Virginia
Conditions: Advanced Cancer, Refractory Cancer, Tumor Gastric
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Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial
NCT02000115
Recruiting
The objective of the PORTICO pivotal IDE trial is to evaluate the safety and effectiveness of the St Jude Medical (SJM) Portico Transcatheter Heart Valve and Delivery Systems (Portico) in the treatment of severe symptomatic aortic stenosis via transfemoral and alternative delivery methods in high risk and extreme risk patients.
Gender:
All
Ages:
21 years and above
Trial Updated:
10/24/2023
Locations: Inova Fairfax Hospital, Falls Church, Virginia
Conditions: Aortic Valve Stenosis
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BEGIN Novel ImagiNG Biomarkers
NCT05517655
Recruiting
To determine the treatment effect of triple-combination therapy in 6-8 year olds after presumed FDA approval, using rapid structural and functional pulmonary and abdominal MRI (UTE and 129Xe).
Gender:
All
Ages:
Between 6 years and 8 years
Trial Updated:
10/23/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Cystic Fibrosis
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Study to Evaluate Efficacy, Safety and Tolerability of HM15211 in Subjects
NCT04505436
Recruiting
This study is a phase 2 study to Evaluate Efficacy, Safety and Tolerability of HM15211 Treatment for 12 Months in Subjects with Biopsy Confirmed NASH
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
10/23/2023
Locations: Bon Secours Liver Institute of Virginia - Newport News, Newport News, Virginia
Conditions: NASH - Nonalcoholic Steatohepatitis
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De-novo Initiation of Letermovir vs Valganciclovir for Cytomegalovirus Prophylaxis in AA Kidney Trans Recip
NCT06001320
Recruiting
CMV viremia will be treated with either oral valganciclovir, intravenous ganciclovir or alternative agents, according to AST ID COP (American Society of Transplantation Infectious disease community of practice) guidelines.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/21/2023
Locations: VCU Medical Center, Richmond, Virginia
Conditions: Kidney Transplant; Complications, CMV
Register for Updates
Lenrispodun as Adjunctive Therapy in the Treatment of Patients With Motor Fluctuations Due to Parkinson's Disease
NCT05766813
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, fixed-dose study in patients with a diagnosis of Parkinson's Disease consistent with the UK Parkinson's Disease Society (UKPDS) Brain Bank diagnostic criteria, who are experiencing wearing off symptoms and levodopa-induced dyskinesia.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
10/20/2023
Locations: Clinical Site, Falls Church, Virginia
Conditions: Parkinson Disease
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A Post-Market Clinical Evaluation of the Treatment of Femur Fractures With the Femoral Nail GT
NCT04015128
Recruiting
This investigation is a prospective, multi-center clinical investigation. It is anticipated that a total of 50 subjects will be enrolled. Neither subjects nor investigators are blinded to treatment and the clinical investigation includes a historical control which will be compared to the Femoral Nail GT of the T2 Alpha Femur Antegrade GT/PF Nailing System. Total duration of enrollment, 12 month follow-up and analysis is expected to take 25 months. The clinical investigation has been designed to... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/20/2023
Locations: Inova Fairfax Medical Campus, Falls Church, Virginia
Conditions: Femoral Fracture
Register for Updates
Impact of a LCD on Metabolic Inflexibility and Cardiovascular Risk in Liver Transplant Patients
NCT04145427
Recruiting
This study is looking to see how a 6-month low carbohydrate diet can affect the body's ability to use energy in addition to the affects it has on the heart and blood vessel health.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2023
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Weight Gain
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Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift
NCT05701969
Recruiting
Anesthesiology residency requires extended and overnight shifts, which may negatively impact the quantity and quality of sleep. Previous studies have investigated the effect of night float shift work on anesthesiology resident sleep and performance and demonstrated that total sleep quantity and time spent in deep and rapid eye movement (REM) sleep were significantly reduced during night float and did not return to baseline after 3 nights of recovery. Melatonin is a hormone produced by the pine... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/18/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Sleep Disorders, Circadian Rhythm
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Tigulixostat, Phase 3 Study, Allopurinol Controlled in Gout Patients
NCT05586971
Recruiting
The aim of this 12-month randomized multi-regional double-blind parallel group allopurinol and placebo-controlled phase 3 study is to assess the efficacy and safety of three different doses of Tigulixostat in gout patients with hyperuricemia.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
10/17/2023
Locations: Meridian Clinical Research, LLC, Portsmouth, Virginia
Conditions: Gout, Hyperuricemia, Gout Flare, Tophi
Register for Updates
Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Subacute and Chronic Iliofemoral DVT
NCT04858776
Recruiting
This is a study of a medical procedure that utilizes a commercially available catheter (the Bullfrog® Micro-Infusion Device) to locally deliver a commercially available anti-inflammatory drug (dexamethasone sodium phosphate injection) around the deep veins after DVT recanalization, where DVT symptoms were present for at least 14 days and no more than 60 days prior to recanalization. The goal of the study is to see if local anti-inflammation helps prevent re-thrombosis of the blood vessel and imp... Read More
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
10/17/2023
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Iliofemoral; Thrombosis
Register for Updates