Virginia is currently home to 1850 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Mucopolysaccharidosis I (MPS I) Registry
NCT00144794
Recruiting
The Mucopolysaccharidosis I (MPS I) Registry is an ongoing, observational database that tracks the outcomes of patients with MPS I. The data collected by the MPS I Registry will provide information to better characterize the natural history and progression of MPS I as well as the clinical responses of patients receiving enzyme replacement therapy, such as Aldurazyme (Recombinant Human Alpha-L-Iduronidase), or other treatment modalities. The objectives of the Registry are: * To evaluate the lon... Read More
Gender:
ALL
Ages:
All
Trial Updated:
11/19/2024
Locations: University of Virginia School of Medicine-Pediatrics- Site Number : 840078, Charlottesville, Virginia
Conditions: Mucopolysaccharidosis I (MPS I)
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Cryospray Therapy for Benign Airway Stenosis
NCT06085209
Recruiting
This is a clinical evaluation to assess the effectiveness of cryospray therapy used in addition to current standard of care endoscopic therapies in preventing short term recurrent airway stenosis with a multicentric outcome evaluation. The investigators hypothesize that the addition of SCT to standard endoscopic treatment of benign airway stenosis will result in decreased stenosis recurrence at 6 months as estimated by quantitative radiologic assessment of the stenotic volume.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Virgnia Commonwealth University, Richmond, Virginia
Conditions: Stenosis Trachea
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Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma
NCT05411198
Recruiting
Glaucoma is the second most common cause of blindness in the world, second only to cataracts. This study will assess how safe and effective a glaucoma gel stent is when implanted using the ab externo approach. Adverse events and intraocular pressure will be assessed. XEN45 is an approved device for the treatment of glaucoma implanted using the ab interno approach (inside the eye). XEN45 implanted using the ab externo approach (outside the eye) is being studied in this study. Approximately 65 pa... Read More
Gender:
ALL
Ages:
45 years and above
Trial Updated:
11/18/2024
Locations: Northern Virginia Ophthalmology Associates -Falls Church /ID# 246925, Falls Church, Virginia
Conditions: Open-Angle Glaucoma
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Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
NCT03808922
Recruiting
This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.
Gender:
ALL
Ages:
All
Trial Updated:
11/18/2024
Locations: VCU Health System, Richmond, Virginia
Conditions: Lower Respiratory Tract Infection, Parainfluenza, Immunocompromised, COVID-19
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Liposomal Bupivacaine Vs Bupivacaine with Dexmedetomidine in Erector Spinae Plane Blocks for Mastectomies
NCT06252662
Recruiting
Perform a comparison of effective pain relief duration between liposomal bupivacaine and dexmedetomidine when added to bupivacaine in a block for mastectomy for cancer surgery. The erector spinae plane block is a well-established block that is utilized for post operative pain control for procedures performed on the soft tissue of the chest and chest wall as well as intrathoracic procedures. The goal is comparison of the effective duration of both study groups to determine if there is a significa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/15/2024
Locations: Naval Medical Center Portsmouth, Portsmouth, Virginia
Conditions: Breast Cancer
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PRCT001 Aquablation theraPy Outcomes in pRostate Cancer patienTs
NCT06051942
Recruiting
The goal of this clinical trial is to assess the performance and safety of the AQUABEAM Robotic System for the resection and removal of prostate tissue in patients experiencing lower urinary tract symptoms (LUTS) and are diagnosed with localized prostate cancer. Participants will go through baseline and follow up assessments up to 12 months.
Gender:
MALE
Ages:
80 years and below
Trial Updated:
11/15/2024
Locations: Potomac Urology Center, Alexandria, Virginia
Conditions: Benign Prostatic Hyperplasia, Localized Prostate Cancer
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Collagen-targeted Positron Emission Tomography (PET) Imaging for Assessment of EGCG Effect
NCT06265532
Recruiting
The primary purpose of this substudy is to determine if collagen-targeted PET using the type 1 collagen-targeted PET probe, Gallium-68 (68Ga)-labeled collagen binding probe 8 (CBP8) can inform as to drug effect of EGCG and assist in dose selection.
Gender:
ALL
Ages:
Between 40 years and 85 years
Trial Updated:
11/14/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Idiopathic Pulmonary Fibrosis
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Study of DISC-0974 to Assess the Safety, Tolerability, PK and PD of DISC-0974 in Participants with CKD and Anemia
NCT05745883
Recruiting
This Phase 1b study of DISC-0974 will assess the safety, tolerability, pharmacokinetics (PK) and Pharmacodynamics (PD) of DISC-0974 in adult participants with Non-Dialysis Dependent Chronic Kidney Disease and Anemia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Washington Nephrology Associates, LLP, Alexandria, Virginia
Conditions: Chronic Kidney Diseases, Anemia of Chronic Kidney Disease
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A Study of YL202 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer and Breast Cancer
NCT05653752
Recruiting
This is a phase 1, multicenter, open-label, first-in-human study of YL202 conducted in the United States and China. The study will evaluate the safety and tolerability of YL202 in patients with locally advanced or metastatic epidermal growth factor receptor (EGFR)-mutated NSCLC or hormone receptor (HR)-positive and HER2-negative BC, which have been heavily treated by standard treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Next Oncology-Virginia, Fairfax, Virginia
Conditions: Non Small Cell Lung Cancer, Breast Cancer
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Effects of Immulina TM Supplements with PASC Patients
NCT05524532
Recruiting
This is a multi-site study that will try to determine the effects of Immulina ™, a natural dietary supplement, on blood chemicals associated with inflammation that are often increased in patients with long COVID (also called PASC).
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/13/2024
Locations: West Virginia University, Morgantown, Virginia
Conditions: Post Acute COVID-19 Syndrome
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Feasibility Study for the Comprehensive Overweight/Obesity Management Pre-Kidney Transplant (COMPKT) Program
NCT06688825
Recruiting
This project will be a single-arm feasibility study, with a treatment intervention that includes three interrelated components: (1) patient education using a proven weight loss curriculum, and (2) technology tools for making healthy lifestyle choices.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Kidney Transplant; Complications, Obesity
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A Study of Valemetostat Tosylate Plus Pembrolizumab Versus Pembrolizumab Alone in First-Line NSCLC Without Actionable Genomic Alterations
NCT06644768
Recruiting
This study will compare Valemetostat Tosylate Plus Pembrolizumab vs Pembrolizumab Alone in First-line NSCLC Without Actionable Genomic Alterations
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Virginia Cancer Specialist, Reston, Virginia
Conditions: Non-small Cell Lung Cancer, Lung Cancer
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