Virginia is currently home to 1866 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Pessary Experience Study
NCT06021769
Recruiting
Pessaries are silicone devices inserted into the vagina for treatment of pelvic organ prolapse or stress urinary incontinence. They are adequate treatment options for patients who are poor surgical candidates, those who decline surgical intervention, or as a temporizing measure in those ultimately planning surgery. Most studies suggest that about 75% of patients are able to be successfully fit with a pessary, but about 50% discontinue pessary use within 12 months of initiation. The purpose of th... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
08/26/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Pelvic Organ Prolapse, Stress Urinary Incontinence
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Reduction in Number of Botox Injections for Urgency Urinary Incontinence
NCT04731961
Recruiting
The overall objective of this study is to determine if a reduced injection site protocol (5 injection sites) using an equivalent amount of Botox provides comparable relief of Urgency Urinary Incontinence (UUI) symptoms compared to the standard injection site protocol (15-20 injection sites). Our central hypothesis is that the 5-site injection protocol is non-inferior in terms of relief of UUI symptoms compared to the standard injection site protocol, measured by a non-inferior reduction in the n... Read More
Gender:
Female
Ages:
21 years and above
Trial Updated:
08/26/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Urgency Urinary Incontinence
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OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study
NCT05405374
Recruiting
The objective of this clinical study is to compare OSTEOAMP SELECT Fibers to Infuse Bone Graft, in terms of effectiveness and safety, when used as a bone graft substitute in in skeletally mature patients qualified for 2-lumbar interbody fusion (LIF) by means of an intra-patient control model.
Gender:
All
Ages:
Between 21 years and 80 years
Trial Updated:
08/25/2023
Locations: OrthoVirginia, Richmond, Virginia
Conditions: Lumbar Spine Disease, Lumbar Spondylolisthesis, Lumbar Spine Instability, Lumbar Spondylosis, Degenerative Disc Disease
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The Effect of Processing on Food Reward
NCT06017986
Recruiting
The minimally processed diets of our ancestors have been rapidly replaced by UPFs driving poor diet to become the leading risk factor for preventable death globally. Hence, it is essential to understand what properties of UPF are driving their overconsumption to reduce diet-related mortality. To address this gap in knowledge this proposal will test: If UPFs have a greater post meal metabolic response when compared to MPFs an essential signal for food reward Through the use of an auction task pa... Read More
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
08/24/2023
Locations: Fralin Biomedical Research Institute at VTC, Roanoke, Virginia
Conditions: Metabolic Diseases
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Tigulixostat, Phase 3 Study, Placebo Controlled in Gout Patients
NCT05586958
Recruiting
The aim of this 6-month randomized multi-regional double-blind parallel group placebo-controlled phase 3 study is to assess the efficacy and safety of three different doses of Tigulixostat in gout patients with hyperuricemia.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
08/24/2023
Locations: Meridian Clinical Research, LLC, Portsmouth, Virginia
Conditions: Gout, Hyperuricemia, Gout Flare, Tophi
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XTX101 Monotherapy and XTX101 and Atezolizumab Combination Therapy in Patients With Advanced Solid Tumors
NCT04896697
Recruiting
This is a first-in-human, Phase 1/2, multicenter, open-label study designed to evaluate the safety and tolerability of XTX101 as monotherapy and XTX101 and atezolizumab combination therapy in patients with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/24/2023
Locations: NEXT Virginia, Fairfax, Virginia
Conditions: Advanced Solid Tumor
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Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs
NCT04301518
Recruiting
This prospective, randomized, controlled study evaluates the safety and efficacy of a preterm birth (PTB) prevention strategy versus standard of care pregnancy management to reduce the incidence of adverse pregnancy outcomes.
Gender:
Female
Ages:
18 years and above
Trial Updated:
08/24/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Preterm Labor, Preterm Birth
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Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH)
NCT02670707
Recruiting
Langerhans Cell Histiocytosis (LCH) is a type of cancer that can damage tissue or cause lesions to form in one or more places in the body. Langerhans cell histiocytosis (LCH) is a cancer that begins in LCH cells (a type of dendritic cell which fights infection). Sometimes there are mutations (changes) in LCH cells as they form. These include mutations of the BRAF gene. These changes may make the LCH cells grow and multiply quickly. This causes LCH cells to build up in certain parts of the body,... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
08/24/2023
Locations: Children's Hospital of The King's Daughters, Norfolk, Virginia
Conditions: Langerhans Cell Histiocytosis
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Fitness-adapted, Pembrolizumab-based Therapy for Untreated Classical Hodgkin Lymphoma Patients 60 Years of Age and Above
NCT05404945
Recruiting
This is a multi-center, open-label phase II study to assess the efficacy of a novel fitness-adapted regimen in previously untreated older patients with classical Hodgkin lymphoma. All participants will receive up to a total of 8 cycles of pembrolizumab (Q6 week dosing). The first cycle of pembrolizumab will be administered in combination with brentuximab vedotin (BV) ("lead-in treatment"). Following lead-in treatment, all participants will undergo interim PET/CT (iPET) as well as fitness testin... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
08/23/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Classical Hodgkin Lymphoma
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Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Acute Femoropopliteal DVT
NCT04862468
Recruiting
This is a study of a medical procedure that utilizes a commercially available catheter (the Bullfrog® Micro-Infusion Device) to locally deliver a commercially available anti-inflammatory drug (dexamethasone sodium phosphate injection) around the deep veins after DVT recanalization, where DVT symptoms were present for up to 14 days prior to recanalization. The goal of the study is to see if local anti-inflammation helps prevent re-thrombosis of the blood vessel and improvement in symptoms for up... Read More
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
08/23/2023
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Thrombosis, Deep Vein, Iliofemoral; Thrombosis
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Study to Evaluate ALIS (Amikacin Liposome Inhalation Suspension) in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex
NCT04677569
Recruiting
The main objective of this study is to evaluate the efficacy of ALIS (amikacin liposome inhalation suspension) + background regimen (azithromycin [AZI] + ethambutol [ETH]) compared to the ELC (empty liposome control) + background regimen on participant-reported respiratory symptoms at Month 13.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/22/2023
Locations: USA083, Charlottesville, Virginia
Conditions: Mycobacterium Infections, Nontuberculous
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IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
NCT04221815
Recruiting
Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) has been shown in clinical trials, registries, and meta-analyses to reduce recurrent events after PCI. This is accomplished by improving the angiographic result with lesion and vessel assessment to guide stent selection and implantation and intravascular imaging following stent implantation to ensure an adequate treatment endpoint has been achieved. Despite extensive literature supporting the use of IVUS in PCI, util... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/21/2023
Locations: Carilion Clinic, Roanoke, Virginia
Conditions: Atherosclerosis
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