Virginia is currently home to 1832 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
PrEP Intervention Among Black Sexual Minority Men
NCT06141408
Recruiting
The goal of the proposed research is to design a peer-based community intervention focused on addressing internalized homophobia, internalized racism, HIV stigma, and peer BSMM support to increase PrEP initiation among BSMM in Prince George's County, MD. Participants will attend intervention events focused on stigma reduction and building community among Black queer men. Researchers will compare intervention and control group participants to see if there in a difference in PrEP initiation and ad... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: George Mason University, Fairfax, Virginia
Conditions: Hiv, Mental Health Issue, Support, Family
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Treatment of PAF With the Synaptic System
NCT05905835
Recruiting
Enrolled subjects will be treated with the Synaptic Cryoablation System. Treatment will include cryoablation of the pulmonary veins to achieve PVI. All subjects will be followed for twelve (12) months after completion of the index ablation procedure.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/09/2023
Locations: VCU Pauley Heart Center, Richmond, Virginia
Conditions: Paroxysmal Atrial Fibrillation
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Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion
NCT04597099
Recruiting
This study is trying to find out if flutamide (a medication that blocks the effects of testosterone) may help normalize an aspect of pituitary function (specifically, gonadotropin surge generation) in PCOS. This is a randomized, placebo-controlled, double-blinded, crossover study. The investigators hypothesize that in estradiol-pretreated women with PCOS, acute progesterone augmentation of FSH release (positive feedback) will be enhanced by flutamide.
Gender:
FEMALE
Ages:
Between 18 years and 30 years
Trial Updated:
11/01/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: PCOS, Polycystic Ovary Syndrome
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Relative Desirability of Metformin vs. Birth Control Pill in Treating PCOS in Women of Later Reproductive Age
NCT03905941
Recruiting
The goal of this study is to determine the relative desirability of metformin vs. oral combined hormonal contraceptives (OCs) in treating Polycystic Ovary Syndrome (PCOS) in women of later reproductive age. Polycystic Ovary Syndrome Questionnaire (PCOSQ) score will be used as a proxy for patient satisfaction. In light of their respective effects on the classic and metabolic facets of PCOS, metformin will provide non-inferior patient satisfaction compared to OCs in later reproductive age women wi... Read More
Gender:
FEMALE
Ages:
Between 40 years and 49 years
Trial Updated:
11/01/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome
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Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS
NCT03905603
Recruiting
The objective of the study is to determine the relative contributions of four established predictors of hyperandrogenism (luteinizing hormone \[LH\] secretion, ovarian response to recombinant human chorionic gonadotropin \[r-hCG\] administration, adrenal response to adrenocorticotropic hormone \[ACTH\] administration, and hyperinsulinemia) in older vs. young women with Polycystic Ovary Syndrome (PCOS) in a cross-sectional, physiological study. The investigators hypothesize that hyperinsulinemia... Read More
Gender:
FEMALE
Ages:
Between 20 years and 49 years
Trial Updated:
11/01/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome
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Study to Assess Potential Impairments in Estradiol Augmentation of Gonadotropin Secretion in Polycystic Ovary Syndrome
NCT03401047
Recruiting
The purpose of this study is to determine if estradiol augmentation of luteinizing hormone (LH) secretion secretion (primary endpoint) and follicle-stimulating hormone (FSH) secretion (secondary endpoint) is reduced in adult women with polycystic ovary syndrome.
Gender:
FEMALE
Ages:
Between 18 years and 30 years
Trial Updated:
11/01/2023
Locations: University of Virginia Clinical Research Unit, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome
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Hyperandrogenemia and Altered Day-night LH Pulse Patterns
NCT03068910
Recruiting
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely reduce waking luteinizing hormone pulse frequency (primary endpoint).
Gender:
FEMALE
Ages:
Between 10 years and 17 years
Trial Updated:
11/01/2023
Locations: University of Virginia Clinical Research Unit, Charlottesville, Virginia
Conditions: Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
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Assessment of Day-night Secretion of Progesterone and LH Across Puberty
NCT02155933
Recruiting
Hormones are substances that are made by the body and are sent directly out into the bloodstream to increase or decrease the function of certain organs, glands, or other hormones. Testosterone is a hormone found in the blood of all girls, but some girls have too much testosterone in their blood. Too much testosterone in the blood can possibly lead to a problem called polycystic ovary syndrome (PCOS). People with PCOS have abnormal menstrual periods, excess facial and body hair, and too much test... Read More
Gender:
FEMALE
Ages:
Between 7 years and 17 years
Trial Updated:
11/01/2023
Locations: Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia
Conditions: Puberty, Hyperandrogenism
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Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone
NCT01428089
Recruiting
During childhood, the levels of certain hormones: gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, and progesterone are very low. However, when puberty starts, GnRH and LH pulses begin to increase, but they initially do so at night only. It is unknown why GnRH and LH pulses increase at night and then decrease during the day (instead of being increased all the time). The purpose of this study is to see how quickly progesterone reduces... Read More
Gender:
FEMALE
Ages:
Between 7 years and 14 years
Trial Updated:
11/01/2023
Locations: Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome, Hyperandrogenism, Normal Puberty
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Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?
NCT04723862
Recruiting
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing hormone (LH) pulse frequency (primary endpoint) and overall LH and follicle-stimulating hormone secretion (secondary endpoints).
Gender:
FEMALE
Ages:
Between 10 years and 17 years
Trial Updated:
10/25/2023
Locations: Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia
Conditions: Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
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Does Treatment of Androgen Excess Using Spironolactone Improve Ovulatory Rates in Girls With Androgen Excess?
NCT04075149
Recruiting
Adolescent girls with androgen excess have a higher rate of irregular periods and decreased ovulation rates compared to normal girls, and are considered at-risk for developing polycystic ovary syndrome (PCOS). This pilot study will look at whether giving spironolactone might improve ovulation rates in girls with androgen excess, ages 13-19. If this is true, spironolactone treatment to young girls might prevent PCOS from developing and avoid future infertility.
Gender:
FEMALE
Ages:
Between 13 years and 19 years
Trial Updated:
10/25/2023
Locations: University of Virginia Center for Research in Reproduction, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome, Puberty Disorders, Ovulation Disorder
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Effects of Gait Retraining on Lower Extremity Biomechanics
NCT03663790
Recruiting
The purpose of this proposed study is to investigate both the acute and chronic response of frontal plane knee moment after gait retraining and to assess the effects on the biomechanics of the contralateral side. Fifty-one patients diagnosed with tibiofemoral joint osteoarthritis (TFJ OA) will be recruited to participate in the proposed study. Participants will complete baseline trials to assess gait kinematic and kinetic parameters. Following baseline, each participant will perform six conditio... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/25/2023
Locations: Sports Medicine, Assessment, Research & Testing (SMART) Laboratory, Manassas, Virginia
Conditions: Knee Osteoarthritis
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