Virginia is currently home to 1861 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults
NCT05468255
Recruiting
The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/09/2024
Locations: Old Dominion University, Norfolk, Virginia
Conditions: Glucose Intolerance, Exercise, Vascular Function
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Tremor Retrainer Software Application for Functional Tremor
NCT06257069
Recruiting
The purpose of this clinical trial is to learn about the Tremor Retrainer smartphone application and Simplified Functional Movement Disorder Rating Scale in patients with functional tremor. The main questions the study aims to answer are: 1. Is the Tremor Retrainer application usable for patients and are there signs that it can help functional tremor? 2. Can a televideo administration of the Simplified Functional Movement Disorder Rating Scale give enough information to use this scale via telev... Read More
Gender:
ALL
Ages:
10 years and above
Trial Updated:
04/08/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Functional Movement Disorder, Functional Neurological Disorder, Functional Neurological Symptom Disorder
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A Long-term Follow-up Study to Evaluate SKG0106 in the Treatment of Patients With nAMD
NCT06346600
Recruiting
This is a Prospective, Non-interventional, Multicenter, Long-term Follow-up Study to Evaluate SKG0106 in the Treatment of Patients with Neovascular (Wet) Age-related Macular Degeneration (nAMD). All subject who completed the parent clinical study (NCT06213038 and NCT05986864) will undergo safety and efficacy assessments up to 5 years post study drug injection.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
04/03/2024
Locations: Wagner Macula & Retina Center, Norfolk, Virginia
Conditions: Neovascular (Wet) Age-related Macular Degeneration
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A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium
NCT05456425
Recruiting
The objective is to evaluate the safety and efficacy of low dose and high dose CBT-001 eye drop dosed twice daily for 24 months compared to vehicle in reducing conjunctival hyperemia and preventing pterygium progression in eyes with pterygia.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
03/29/2024
Locations: Emerson Clinical Research Institute, LLC, Falls Church, Virginia
Conditions: Pterygium
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Phase II Trial of Neoadjuvant and Adjuvant IO102-IO103 and Pembrolizumab KEYTRUDA® in Patients With Resectable Tumors
NCT05280314
Recruiting
This is a multicenter, multi-arm trial evaluating anti-tumor activity, safety, and immune infiltration of IO102-IO103 in combination with pembrolizumab KEYTRUDA® as neoadjuvant and post-surgery treatment. This proof-of-concept trial will include patients with resectable tumors in at least 2 indications.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/15/2024
Locations: Massey Cancer Center, Richmond, Virginia
Conditions: Melanoma, Squamous Cell Carcinoma of Head and Neck
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A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT06322693
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: GSK Investigational Site, Fairfax, Virginia
Conditions: Neoplasms
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Biomarkers Related to Bone in Pediatric Gaucher Disease
NCT06116071
Recruiting
Aims of the observational study is to establish novel blood-based biomarkers for grading bone disease in pediatric patients with Gaucher disease (GD). Patients with clinically confirmed GD: deficient GCase enzyme activity and corresponding genetic analysis will be eligible for enrollment. Levels of Lyso-Gb1, chitotriosidase, and CCL18 will be established for future bone biomarkers correlation analysis. Skeletal involvement will be assessed using standard clinical diagnostic tools, such as skelet... Read More
Gender:
ALL
Ages:
Between 5 years and 21 years
Trial Updated:
03/12/2024
Locations: Lysosomal and Rare disorder research and treatment center, Fairfax, Virginia
Conditions: Gaucher Disease, Bone Diseases
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Telemedicine Use in Preoperative Counseling for Endometrial Cancer Survivors
NCT05712668
Recruiting
To determine whether telemedicine is an acceptable addition to pre-operative counseling, compared to face-to-face communication alone for patients with endometrial cancer.
Gender:
FEMALE
Ages:
All
Trial Updated:
03/08/2024
Locations: Carilion Clinic, Roanoke, Virginia
Conditions: Telemedicine, Counseling
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The Natural History Study of Patients With Sanfilippo Disease(s) (MPS3)
NCT05705674
Recruiting
The natural history study of patients with Sanfilippo disease(s) (MPS3)
Gender:
ALL
Ages:
Between 5 years and 99 years
Trial Updated:
03/07/2024
Locations: LDRTC, Fairfax, Virginia
Conditions: Sanfilippo Syndrome, MPS3
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A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
NCT05442567
Recruiting
The study is an extension of two parent studies (MLN0002-3024 \[NCT04779307\] and MLN0002-3025 \[NCT04779320\]). Participants must have participated in one of the previous studies. The purpose of this study is to collect the long-term safety of vedolizumab in children with UC or CD.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/05/2024
Locations: Carilion Children's Tanglewood Center, Roanoke, Virginia
Conditions: Ulcerative Colitis, Crohn's Disease
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Evaluation of Symphony™ Posterior Cervical System for Surgical Treatment of Adult Cervical Deformity
NCT04912674
Recruiting
Multi-center, prospective, non-randomized study to evaluate Symphony™ Posterior Cervical System in the setting of surgical treatment of adult cervical deformity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Cervical Deformity
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Radiographic and Clinical Evaluation of Surgical Treatment for Cervical Deformity: A Multi-Center Study 2.0
NCT04194996
Recruiting
Multi-center, prospective, non-randomized study to evaluate outcomes of surgically treated patients with adult cervical spinal deformity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Cervical Deformity
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