Virginia is currently home to 1853 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Wearable Spine Health System for Military Readiness
NCT05944354
Recruiting
The goal of this observational trial is to compare the health history and motion capabilities of participants with low back pain disorders to participants with healthy spines. The main question\[s\] it aims to answer are to: 1. Primary outcomes of this research effort include the development of composite measures or digital biomarkers to track functional recovery over time and predict duty or work status outcomes (return-to-full duty/work, limited duty/work restrictions or medical discharge/lon... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
01/22/2024
Locations: Joint Base Langley- Eustis Air Force Base, Langley Air Force Base, Virginia
Conditions: Low Back Pain, Neck Pain
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rTMS for Neuroenhancement
NCT06214871
Recruiting
The purpose of this pilot study is to evaluate the effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Sleep Quality, Mood and Memory.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
01/19/2024
Locations: Gerrish MedEsthetics, Vienna, Virginia
Conditions: Sleep
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Patient Augmented Reality and Vibratory Array Otorhinolaryngology Procedures
NCT06227039
Recruiting
In-office procedures (IOPs) are a cost-effective, and safe alternative to many operating room procedure, with benefits such as reduced anesthesia risk. One of the major causes of failed in-office procedures or requirement of conversion to the operating room is poor patient tolerance. Vibration and augmented reality (AR) can be used as non-pharmacologic treatment options to treat patient anxiety and pain by using the physiology proposed by the gate-way theory of pain as well as distraction. This... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2024
Locations: UVA Fontaine Research Park Building 415, Charlottesville, Virginia
Conditions: Pain, Acute, Vocal Fold Polyp, Vocal Cord Paralysis, Laryngeal Neoplasms
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Voice Rest and Injection Laryngoplasty
NCT05542550
Recruiting
The purpose of this study is to evaluate the subjective, objective, and aerodynamic impact of voice rest following injection augmentation and compare the outcomes to patients with no post-procedure voice restrictions.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
01/17/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Vocal Cord Paralysis
Register for Updates
Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)
NCT03883412
Recruiting
The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and muscle capillary blood volume, improves vascular function in the larger conduit vessels, and enhances insulin's metabolic action in humans with Type 2 diabetes. Subjects will be randomized to one of the three groups: exercise training, liraglutide treatment, and exercise + liraglutide. They will be studied at the base... Read More
Gender:
ALL
Ages:
Between 21 years and 60 years
Trial Updated:
12/19/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Type2 Diabetes
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TPIV100 and Sargramostim for the Treatment of HER2 Positive, Stage II-III Breast Cancer in Patients With Residual Disease After Chemotherapy and Surgery
NCT04197687
Recruiting
This phase II trial studies how well TPIV100 and sargramostim work in treating patients with HER2 positive, stage II-III breast cancer that has residual disease after chemotherapy prior to surgery. It also studies why some HER2 positive breast cancer patients respond better to chemotherapy in combination with trastuzumab and pertuzumab. TPIV100 is a type of vaccine made from HER2 peptide that may help the body build an effective immune response to kill tumor cells that express HER2. Sargramostim... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/15/2023
Locations: Inova Fairfax Hospital, Falls Church, Virginia
Conditions: Breast Adenocarcinoma, Stage II Breast Cancer AJCC v6 and v7, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7, Stage III Breast Cancer AJCC v7, Stage IIIA Breast Cancer AJCC v7, Stage IIIB Breast Cancer AJCC v7, Stage IIIC Breast Cancer AJCC v7
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Evaluation of the Effectiveness of Nail Genesis DLSO Product for Onychomycosis
NCT06074315
Recruiting
This is a Pre-IDE, prospective, multicenter, randomized, parallel-group, double-blind, vehicle- controlled study to evaluate safety and effectiveness of Nail Genesis DLSO Product for the treatment of DLSO compared with vehicle in infected great toenails in a total of 338 males and non-pregnant, non-lactating, females between 18 and 65 years of age (inclusive). Subjects will be randomized in a 2:1 ratio to receive either Nail Genesis DLSO Product or vehicle. Subject eligibility will be determine... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/06/2023
Locations: The Education & Research Foundation, Inc., Lynchburg, Virginia
Conditions: Distal Lateral Subungual Onychomycosis, Onychomycosis
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Management of Antiplatelet Regimen During Surgical Procedures
NCT03981835
Recruiting
There are key differences today in clinical practice regarding perioperative management of post-PCI patients on DAPT undergoing NCS. Moreover, there are significant differences between bridging agents, and improved safety of current-generation DES. Given the significant limitations of current studies a well-designed registry to study current U.S. practice patterns and the bleeding or ischemic risks associated with the various perioperative DAPT management strategies including bridging and no bri... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Mary Washington Hospital, Fredericksburg, Virginia
Conditions: Cardiac Surgery, Surgery, Percutaneous Coronary Intervention, Surgery--Complications
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Optimizing Pain Self-Management in Total Knee Arthroplasty
NCT06038240
Recruiting
The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee arthroplasty (TKA). The scientific premise is that patient use of a positive emotion generative practice - savoring meditation, which has been demonstrated to reduce pain in experimental laboratory settings, enhanced with a pain neuroscience education component about reward syste... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
11/29/2023
Locations: Fontaine Research Park, Charlottesville, Virginia
Conditions: Osteo Arthritis Knee, Knee Pain Chronic, Surgery
Register for Updates
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
NCT06009276
Recruiting
The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle. Participants will complete all or some of the following: * A mouth swab to assess the bacteria in their mouths. * Produce a saliva sample into a tube. * Cycle on a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: UVA Student Health and Wellness Building, Charlottesville, Virginia
Conditions: Heart Failure, Systolic, Heart Failure, Diastolic, Peripheral Arterial Disease, Overweight and Obesity
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The Use of Memantine for Prevention of Alzheimer's Disease
NCT05063851
Recruiting
As the US population ages, the prevalence of dementia is increasing, and Alzheimer's Disease (AD) is the most prevalent one. Solving the Alzheimer's Disease (AD) epidemic is likely to require preventive therapy beginning many years before symptoms are expected to be evident in at-risk individuals. AD is caused by the dysfunction, loss of synapses, and eventual neuronal death, which may occur up to 25 years before clinical symptoms appear. This study, based off of pre-clinical data, seeks to asse... Read More
Gender:
ALL
Ages:
Between 50 years and 65 years
Trial Updated:
11/28/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Alzheimer Disease
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The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion During Exercise in Patients With PAD
NCT05036213
Recruiting
Peripheral arterial disease (PAD) is a highly prevalent and costly condition. Intermittent claudication (IC), defined as ischemic leg pain that occurs with walking, results in functional impairment, reduced daily physical activity, and a lower quality of life. Although the mechanisms contributing to functional impairment are not fully delineated, current evidence suggests that the uncoupling of skeletal muscle cellular metabolism from tissue perfusion may be responsible for exercise intolerance.... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
11/28/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Peripheral Arterial Disease, Peripheral Vascular Diseases
Register for Updates