Virginia is currently home to 1832 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Go Girls! Fitness Support Group Intervention Effectiveness Study
NCT02117063
Recruiting
The main purpose of this study is to determine if the Go Girls! program to take place at the Kluge Children's Rehabilitation Center Therapeutic Recreation Gymnasium, intended to introduce girls to a fun, non-threatening environment of exercise with peer support, improves scores on a physical activity enjoyment scale (PACES). Information regarding enjoyment of physical activity before and after the program will allow objective evaluation of whether the program is achieving its mission. Qualitativ... Read More
Gender:
FEMALE
Ages:
Between 10 years and 18 years
Trial Updated:
10/25/2023
Locations: Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome, Abnormal Weight Gain, Excess Weight, Insulin Resistance, Premature Adrenarche, Type 2 Diabetes Mellitus
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Effect of Spironolactone on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess
NCT01422759
Recruiting
Whether 12 weeks of spironolactone can reduce androgen production from ovaries and adrenal glands of girls with obesity and androgen excess
Gender:
FEMALE
Ages:
Between 7 years and 18 years
Trial Updated:
10/25/2023
Locations: University of Virginia Center for Research in Reproduction, Charlottesville, Virginia
Conditions: Obesity, Hyperandrogenemia, Polycystic Ovary Syndrome
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Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess
NCT01422746
Recruiting
This study will test whether metformin administration can ameliorate androgen (male hormone) overproduction in overweight pubertal girls with androgen excess. The investigators hypothesize that improvement in insulin sensitivity by 12 weeks of metformin administration will improve androgen levels after adrenal stimulation testing with adrenocorticotropic hormone (ACTH) or ovarian stimulation testing with recombinant human chorionic gonadotropin (rhCG).
Gender:
FEMALE
Ages:
Between 7 years and 18 years
Trial Updated:
10/25/2023
Locations: University of Virginia Center for Research in Reproduction, Charlottesville, Virginia
Conditions: Obesity, Hyperandrogenemia, Polycystic Ovary Syndrome
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Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift
NCT05701969
Recruiting
Anesthesiology residency requires extended and overnight shifts, which may negatively impact the quantity and quality of sleep. Previous studies have investigated the effect of night float shift work on anesthesiology resident sleep and performance and demonstrated that total sleep quantity and time spent in deep and rapid eye movement (REM) sleep were significantly reduced during night float and did not return to baseline after 3 nights of recovery. Melatonin is a hormone produced by the pine... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Sleep Disorders, Circadian Rhythm
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Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Subacute and Chronic Iliofemoral DVT
NCT04858776
Recruiting
This is a study of a medical procedure that utilizes a commercially available catheter (the Bullfrog® Micro-Infusion Device) to locally deliver a commercially available anti-inflammatory drug (dexamethasone sodium phosphate injection) around the deep veins after DVT recanalization, where DVT symptoms were present for at least 14 days and no more than 60 days prior to recanalization. The goal of the study is to see if local anti-inflammation helps prevent re-thrombosis of the blood vessel and imp... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
10/17/2023
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Iliofemoral; Thrombosis
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Low-Intensity Focused Ultrasound For Insular Neuromodulation in Chronic Pain
NCT05751096
Recruiting
Study investigating the potential benefit for chronic pain patients (CRPS and FM) using low-intensity focused ultrasound for neuromodulation.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/12/2023
Locations: Fralin Biomedical Research Institute, Roanoke, Virginia
Conditions: Fibromyalgia, Complex Regional Pain Syndromes, Chronic Pain
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Assess Urine Biomarkers to Predict Nephropathy in Fabry Disease
NCT06065605
Recruiting
The purpose of this research is to collect biological samples (urine) to develop assays for immune biomarkers to possibly in the future be able to screen subjects with Fabry disease and be able to understand better progression of nephropathy in Fabry disease and predict nephropathy in Fabry disease.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/29/2023
Locations: Lysosomal & Rare Disorders Research & Treatment Center, Fairfax, Virginia
Conditions: Fabry Disease
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Post-Approval Study of the TREO Abdominal Stent-Graft System
NCT04697784
Recruiting
The purpose of this study is to determine the long-term performance of the TREO Abdominal Stent-Graft as a treatment for patients with Infrarenal Abdominal Aortic Aneurysms or Aorto-iliac Aneurysms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: Sentara Heart Hospital, Norfolk, Virginia
Conditions: Abdominal Aortic Aneurysm
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SPR PNS for Chronic Shoulder Pain
NCT05649917
Recruiting
The purpose of this research is to gather post-market data regarding the effectiveness of the SPRINT Peripheral Nerve Stimulation (PNS) System for the treatment of chronic shoulder pain due to chronic degenerative changes of your shoulder. The System delivers mild electrical stimulation to the muscles in your shoulder. The System includes up to two leads (small wires) that are placed through your skin into your shoulder. The leads attach to a device worn on your body that deliver stimulation (ca... Read More
Gender:
ALL
Ages:
Between 21 years and 100 years
Trial Updated:
09/26/2023
Locations: International Spine Pain & Performance Center, Arlington, Virginia
Conditions: Shoulder Pain, Shoulder Injuries, Shoulder Arthritis
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OPN-375 Efficacy and Safety in Adolescents With Bilateral Nasal Polyps
NCT03747458
Recruiting
This is a 16-Week Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multicenter Study Evaluating the Efficacy and Safety of OPN-375 186 μg Twice a Day (BID) in Adolescents with Bilateral Nasal Polyps followed by a 12-Week Open-Label Treatment Phase. The total planned number of subjects is approximately 120 adolescents (12-17 years of age) who will be randomly assigned to receive 1 of 2 study treatments using a 2:1 ratio (OPN-375 186 μg: Placebo). For the PK sub-study, up to 14 subjec... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
09/22/2023
Locations: Eastern Virginia Medical School - Otolaryngology, Norfolk, Virginia
Conditions: Bilateral Nasal Polyposis
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A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations
NCT05163028
Recruiting
A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS or EGFR mutations to determine the maximum tolerated dose and recommended Phase II dose of HBI-2376 and characterize its pharmacokinetic profile.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2023
Locations: Virginia Cancer Specialists, Fairfax, Virginia
Conditions: Non Small Cell Lung Cancer, Colorectal Cancer, Pancreatic Cancer, Solid Tumor, Cancer, Cancer of Pancreas, Cancer of Colon
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INTERCEPT Blood System for RBCs Study in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections
NCT03037164
Recruiting
Stage A: To evaluate the safety and efficacy of red blood cells (RBCs) prepared with the INTERCEPT Blood System for Red Blood Cells Pathogen Reduction Treatment (PRT) in comparison to conventional RBCs in patients who require RBC transfusion support. Stage B: To provide early access to the INTERCEPT pathogen reduction system for RBC in regions where a substantial proportion of the population has been infected or is at risk of a transfusion-transmissible infection. The objectives and design of... Read More
Gender:
ALL
Ages:
4 years and above
Trial Updated:
09/11/2023
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Anemia
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