There are currently 104 active clinical trials seeking participants for Asthma research studies. The states with the highest number of trials for Asthma participants are California, Texas, Florida and Ontario.
CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids
NCT04518722
Recruiting
The goal of this study is to assess the feasibility of emerging CT-based tools to measure changes in central and peripheral bone density, micro-structure, and marrow adipose tissue (MAT) among patients treated with oral steroids.
Gender:
All
Ages:
Between 25 years and 45 years
Trial Updated:
04/08/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Asthma, Bone Density, Low, Oral Steroid-Dependent Asthma (Disorder)
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Finding Correlations Between Asthma Exacerbation, Physiological Measurements and Environmental Factors
NCT04845932
Recruiting
To identify asthma-related physiological changes observed by wearable devices in real-world conditions by monitor multiple sensing modalities (e.g., heart rate (HR), heart rate variability (HRV), activity level, spirometry, coughing sounds) in order to find reliable signatures of impending asthma exacerbation and systematically explore any challenges on the use of wearable technologies.
Gender:
All
Ages:
Between 14 years and 18 years
Trial Updated:
03/25/2024
Locations: UNC Children's Raleigh Clinic, Raleigh, North Carolina
Conditions: Asthma
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The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
NCT06152653
Recruiting
The goal of this clinical trial is to determine if positive pressure during inspiration will improve penetration of aerosolized N-Acetylcysteine (NAC) into airway mucus plugs in the lungs of patients with asthma or Chronic Obstructive Pulmonary Disease (COPD). The main questions it aims to answer are: Does delivery of aerosolized NAC with positive inspiratory pressure have a greater effect on mucus plug burden in the lungs than delivery of NAC without positive pressure. Does delivery of aeroso... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
03/15/2024
Locations: UCSF Airway Clinical Research Center, San Francisco, California
Conditions: Asthma, COPD
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Microbes and Respiratory Illnesses
NCT06059027
Recruiting
This study is called the Microbes and Respiratory Illnesses (MARI) Study. Children growing up on farms are exposed to many types of microbes that could be beneficial. It is thought that increased exposure to certain types of microbes early in life helps to develop a healthy immune system and reduce the risk for severe common cold illnesses, breathing problems, and allergies.
Gender:
All
Ages:
Between 4 years and 12 years
Trial Updated:
03/13/2024
Locations: University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Conditions: Virus, Asthma
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Project 2 Airway Potential Hydrogen (pH) in Asthma
NCT03617718
Recruiting
This study is testing a non invasive way to measure airway pH in individuals with Asthma and Cystic Fibrosis using a new inhaled drug. The airway pH will help health care providers in creating tailored treatment plans for individuals suffering from these specific conditions.
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
03/13/2024
Locations: Indiana University School of Medicine, Indianapolis, Indiana +1 locations
Conditions: Cystic Fibrosis, Asthma, Severe Persistent Asthma, Healthy
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Anti Inflammatory Lipid Mediators in Asthma Lipid Anti-Inflammtory Mediators in Asthma
NCT03762395
Recruiting
The main purpose of this Phase 2 double blind, placebo controlled crossover clinical study is to demonstrate the efficacy and safety of CXA-10 in obese adult asthmatics. Obesity induces a chronic systemic inflammatory state characterized by impaired adipokine signaling, pro-inflammatory cytokine responses, inflammatory cell activation and enhanced generation of oxidative inflammatory mediators. This impacts the lung, increasing the severity of asthma and its exacerbations. This research will eva... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/29/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Asthma, Obesity
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Individualizing Treatment for Asthma in Primary Care
NCT06272370
Recruiting
This is a patient level randomized trial for teenagers and adults with asthma who will be randomized to four arms - enhance usual care, rescue inhaled corticosteroids, azithromycin and both rescue inhaled corticosteroids and azithromycin. Participants in all arms will be offered access to an online asthma symptom monitoring system.
Gender:
All
Ages:
Between 12 years and 75 years
Trial Updated:
02/20/2024
Locations: DARTNet Insitute, Aurora, Colorado
Conditions: Asthma, Bronchial Diseases, Respiratory Tract Infections, Lung Diseases, Obstructive, Lung Diseases, Respiratory Hypersensitivity, Immune System Diseases
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A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma.
NCT05763121
Recruiting
This study will assess the efficacy and safety of dexpramipexole as an adjunctive oral therapy in participants with inadequately controlled asthma with an eosinophilic phenotype and a history of asthma exacerbations.
Gender:
All
Ages:
Between 12 years and 99 years
Trial Updated:
02/09/2024
Locations: Research Site 20001-062, Newport Beach, California +124 locations
Conditions: Eosinophilic Asthma, Asthma; Eosinophilic, Asthma
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A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma (EXHALE-3)
NCT05813288
Recruiting
The objective of this clinical study is to investigate the safety, tolerability, and efficacy of dexpramipexole in participants with inadequately controlled severe eosinophilic asthma.
Gender:
All
Ages:
Between 12 years and 99 years
Trial Updated:
02/09/2024
Locations: Research Site 30001-287, Mobile, Alabama +45 locations
Conditions: Eosinophilic Asthma, Asthma; Eosinophilic, Asthma
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BREATHE: An Efficacy-implementation Trial Among Black Adults With Uncontrolled Asthma
NCT05341726
Recruiting
This study is an efficacy-implementation trial to: evaluate systematically the efficacy of BREATHE in 200 Black adults receiving care at urban federally qualified health centers (FQHCs) for uncontrolled asthma; and identify multi-level barriers and facilitators to the widespread adoption and implementation of BREATHE in FQHCs.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: Sun River Health, Beacon, New York +1 locations
Conditions: Asthma
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Terbutaline Sulfate in Adults With Asthma
NCT04973345
Recruiting
The overall aim in Part 1 is to compare the pharmacokinetic (PK)/pharmacodynamics (PD) relationship in intravenous (IV) versus subcutaneous (SQ) terbutaline sulfate to identify the optimal IV dosing range for use in Part 2. The overall aim in Part 2 is to evaluate the optimal IV dosing of terbutaline sulfate based on PD response and safety data.
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
01/02/2024
Locations: Duke Early Phase Research Unit (DEPRU), Durham, North Carolina
Conditions: Asthma
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AZithromycin Therapy in Preschoolers With a Severe Wheezing Episode Diagnosed at the Emergency Department
NCT04669288
Recruiting
AZ-SWED is a parallel group, double blind, placebo control efficacy clinical trial with two separate hypotheses. The trial will compare the 5-day outcome of preschool children presenting to an Emergency Department (ED) with an acute, severe wheezing episode and treated with either once daily oral Azithromycin (12 mg/kg/day for 5 days) or placebo. The AZ-SWED researchers will make separate comparisons in children in whom specific pathogenic bacteria are isolated from nasopharyngeal swabs, and in... Read More
Gender:
All
Ages:
Between 18 months and 60 months
Trial Updated:
01/02/2024
Locations: Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia +7 locations
Conditions: Asthma, Wheezing
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