There are currently 89 active clinical trials seeking participants for Asthma research studies. The states with the highest number of trials for Asthma participants are California, Texas, Florida and Ontario.
Spirometric Response to Bronchial Thermoplasty in Patients With Severe Asthma
NCT02241265
Recruiting
The investigators hypothesis is that there will be improvement in FEV1 in patients with severe asthma. This is a retrospective data study that reviews preexisting medical records; no patients will be enrolled.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/06/2025
Locations: OUHSC, Oklahoma City, Oklahoma
Conditions: Asthma
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BREATHE: An Efficacy-implementation Trial Among Black Adults With Uncontrolled Asthma
NCT05341726
Recruiting
This study is an efficacy-implementation trial to: 1. evaluate systematically the efficacy of BREATHE in 200 Black adults receiving care at urban federally qualified health centers (FQHCs) for uncontrolled asthma; and 2. identify multi-level barriers and facilitators to the widespread adoption and implementation of BREATHE in FQHCs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2025
Locations: Sun River Health, Beacon, New York +1 locations
Conditions: Asthma
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Viral Mucosal Reprogramming
NCT05331170
Recruiting
This is a mechanistic, controlled, open-label, single-site study to evaluate the effects of RG-RV16 inoculation on airway mucosal gene expression and airway remodeling in 25 healthy controls (HC), in 25 allergic rhinitis subjects (AR) with cat dander allergy, and in 25 allergic asthmatic subjects (AA) with cat dander allergy. Three groups (HC, AR, and AA) will undergo screening to establish clinical history, will undergo pulmonary function testing (spirometry), and will have blood drawn for clin... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
01/24/2025
Locations: University of Texas Medical Branch, Galveston, Texas
Conditions: Asthma, Allergic Rhinitis, Cat Allergy, Healthy
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A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma
NCT06637371
Recruiting
The main objective of this study is to assess the safety and tolerability of AMG 691 as single doses (healthy participants only) and multiple doses in healthy participants and participants with mild-to-moderate asthma.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/22/2025
Locations: Orange County Research Center, Lake Forest, California +2 locations
Conditions: Asthma
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Reducing Overuse of Antibiotics with Decision Support
NCT06788093
Recruiting
Eliminating inappropriate antibiotic use in pediatric lower respiratory tract infections (LRTI) is the central focus of this research. LRTIs (pneumonia, bronchiolitis, and infection-related exacerbations of asthma) account for nearly one-third of all emergency department (ED) visits and 40% of all infection-related hospitalizations in US children. LRTIs also account for more antibiotic use in children's hospitals than any other condition, despite most LRTIs being viral in nature. Inappropriate a... Read More
Gender:
ALL
Ages:
Between 6 months and 17 years
Trial Updated:
01/16/2025
Locations: Benioff Children's Hospital - Oakland, Oakland, California +2 locations
Conditions: Lower Respiratory Tract Infection, Pneumonia, Asthma, Bronchiolitis, Viral
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Hospital to Home Study: Trial to Optimize Transitions and Address Disparities in Asthma Care
NCT05991115
Recruiting
Caregiver-child dyads will be recruited during child's hospital admission for asthma exacerbation. Recruitment sites will be mainly Children's National Hospital Sheikh Zayed campus, as well as regional partners: Holy Cross Hospital, and Mary Washington Hospital. After enrollment, baseline data will be collected from caregiver. Caregiver-child dyads will be randomized (1:1 ratio) into the control arm or intervention arm. Control arm will receive the standard of care after hospital discharge. Inte... Read More
Gender:
ALL
Ages:
Between 4 years and 12 years
Trial Updated:
01/09/2025
Locations: Children's National Hospital, Washington DC, District of Columbia
Conditions: Asthma, Asthma in Children
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Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care
NCT06422689
Recruiting
ANCHOR is a prospective, multi-center, phase IV, interventional, single-arm, open-label study of 2,000 adult participants with symptomatic asthma requiring the use of rescue therapy aimed to compare the asthma exacerbation rates before and after switching from albuterol or levalbuterol to albuterol plus budesonide inhalation aerosol as rescue therapy.
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
01/07/2025
Locations: Research Site, Boston, Massachusetts +5 locations
Conditions: Asthma
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Metformin IN Asthma for Overweight and Obese Individuals (MINA)
NCT06273072
Recruiting
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/02/2025
Locations: Johns Hopkins University, Baltimore, Maryland +1 locations
Conditions: Asthma, Asthma Chronic, Overweight and Obesity
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Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma
NCT06307665
Recruiting
The purpose of this study is to compare the effect of budesonide/albuterol metered-dose inhaler (BDA MDI) with albuterol sulfate metered-dose inhaler (AS MDI), both administered as needed, on the annualized rate of severe asthma exacerbations in adolescents with a documented clinical diagnosis of asthma and at least one severe exacerbation in the prior year.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
12/19/2024
Locations: Research Site, Anchorage, Alaska +108 locations
Conditions: Asthma
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Measuring the Effect of Dupilumab Treatment on Mucociliary Clearance (MCC) in Subjects With Moderate to Severe Asthma
NCT04743791
Recruiting
Single center, randomized, placebo- controlled study to assess change in mucociliary clearance of moderate to severe asthma patients after treatment with dupilumab or placebo.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/10/2024
Locations: The University of Pittsburgh Asthma Institute at UPMC, Pittsburgh, Pennsylvania
Conditions: Asthma
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Innate Immunity in Allergic Asthma
NCT06068335
Recruiting
The purpose of this study is to determine whether a potential type 2 signature, obtained through stimulation of cell lines with various allergens in vitro, correlates with an allergic or asthmatic disease state ex vivo. This type 2 signature will be multi-hierarchical in nature and will be comprised cell surface receptor expression, pathway activation, and gene upregulation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: University of Central Florida, Orlando, Florida
Conditions: Asthma
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AeviceMD for Detection of Wheeze in Pediatric and Adult Populations
NCT06691971
Recruiting
Respiratory signs and symptoms consisting of wheeze, cough, and breathlessness are obtained in a manual fashion through history taking and physical examination by the healthcare professional. Auscultation of the lung assesses airflow through the trachea-bronchial tree and is helpful in diagnosing various respiratory disorders. AeviceMD is a wearable device that can acquire and process lung sounds, thus assisting in the detection of abnormal lung sounds. The primary objective of this study is to... Read More
Gender:
ALL
Ages:
3 years and above
Trial Updated:
11/17/2024
Locations: Montefiore Medical Center, Bronx, New York
Conditions: Subject Presenting Wheeze, Asthma, Bronchial Disease, Respiratory Tract Diseases, Pediatric Asthma, Chronic Respiratory Disease
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