The Effect of Interval Exercise on Functional Outcomes in Veterans With COPD and OSA
NCT05254431
Recruiting
The term "Overlap Syndrome" (OS) is used to describe the presence of both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in a single patient. Due to premature aging, patients with OS are prone to developing functional decline up to 20 years earlier than the general population. The International Classification of Functioning, Disability and Health (ICF) evaluates functional status in chronic pulmonary disease globally in 5 domains. The investigators propose to stud... Read More
Gender:
All
Ages:
All
Trial Updated:
04/18/2023
Locations: Salem VA Medical Center, Salem, VA, Salem, Virginia
Conditions: COPD, OSA
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The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
NCT06152653
Recruiting
The goal of this clinical trial is to determine if positive pressure during inspiration will improve penetration of aerosolized N-Acetylcysteine (NAC) into airway mucus plugs in the lungs of patients with asthma or Chronic Obstructive Pulmonary Disease (COPD). The main questions it aims to answer are: Does delivery of aerosolized NAC with positive inspiratory pressure have a greater effect on mucus plug burden in the lungs than delivery of NAC without positive pressure. Does delivery of aeroso... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
11/22/2023
Locations: UCSF Airway Clinical Research Center, San Francisco, California
Conditions: Asthma, COPD
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High Flow vs Conventional Oxygen in Head and Neck Surgery
NCT05362526
Recruiting
Patients undergoing major head and neck surgery are at risk for postoperative pulmonary complications. The goal of this randomized clinical trial is to evaluate the effectiveness of high flow heated humidified oxygen at preventing postoperative pulmonary complications after major head and neck surgery, when compared to conventional oxygen therapy (aerosol cool mist).
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
11/17/2023
Locations: University of Florida, Jacksonville, Florida
Conditions: Pulmonary Disease, COPD
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Prospective, Observational Study of Wellinks Effect on COPD Hospital Readmissions
NCT05330507
Recruiting
This prospective, observational study is designed to investigate clinical outcomes and collect patient feedback on the use of Wellinks, an integrated virtual chronic obstructive pulmonary disease (COPD) management solution, for patients recently discharged from the hospital due to an acute exacerbation of their COPD.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/31/2023
Locations: Hartford Hospital, Hartford, Connecticut
Conditions: COPD, Respiratory Tract Disease, Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive, Lung Diseases
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Pulmonary Hypertension SOLAR
NCT04778046
Recruiting
The main goal of this study is to develop a noninvasive signature for pulmonary vascular remodeling in Group 3 PH patients, using hyperpolarized 129Xe magnetic resonance imaging (129Xe MRI). Such a signature may identify Group 3 PH responders to PAH-specific therapies. PAH's unique 129Xe MRI signature has been shown in previous studies. Past studies have lacked a pathologic "ground truth" correlate of these signatures, which could be provided by comparing them with the pathology of lung explant... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/20/2023
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Interstitial Lung Disease, COPD, Pulmonary Arterial Hypertension
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Relationship of Inflammation and Pulmonary Function to Fungal Translocation in HIV
NCT05502653
Recruiting
The investigator will study the origin of fungal translocation in HIV, its relationship to the mycobiome, and its relationship to lung function and inflammation. Supported by the preliminary data and published studies, this project is based on the premise that circulating BDG derived from microbial translocation stimulates inflammation and worsens lung function in PWH. Chronic obstructive pulmonary disease (COPD) is a significant public health problem with few therapies that modify disease traj... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
09/11/2023
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: HIV Infections, Inflammation, COPD
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A Study of Patients With Chronic Disease
NCT04263727
Recruiting
TARGET-RWE is a 10-year, international, longitudinal, observational study of patients with chronic disease designed to specifically address important clinical questions that remain incompletely answered from registration trials. The protocol will follow a master protocol design in which a shared study infrastructure supports progressive development of the registry across the spectrum of chronic diseases.
Gender:
All
Ages:
All
Trial Updated:
08/24/2023
Locations: Asthma and Allergy Associates, PC, Colorado Springs, Colorado +4 locations
Conditions: Asthma, Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis, IPF, COPD, Respiratory Disease
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myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
NCT05204888
Recruiting
Parallel-group, prospective, randomized, controlled phase III trial of home High flow Nasal Therapy (HFNT) via myAirvo 3 plus usual COPD medical care vs. usual COPD medical care, for at least 1 year and up to two years in 642 GOLD Grade D, Stages II-IV patients with moderate to very severe COPD at risk for moderate and severe exacerbations with a prior history of severe exacerbation requiring hospitalization within the past 6 weeks.
Gender:
All
Ages:
30 years and above
Trial Updated:
08/15/2023
Locations: Lahey Hospital and Medical Center, Burlington, Massachusetts +8 locations
Conditions: COPD
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The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity
NCT04953806
Recruiting
Chronic Obstructive Pulmonary Disease (COPD) is prevalent and debilitating chronic disease in Veterans. COPD is highly co-morbid with depression and anxiety conferring greater morbidity and mortality risk. Physical activity is a modifiable behavior that can improve COPD outcomes. However, to date, interventions targeting physical activity have not addressed the high comorbidity between COPD and depression and/or anxiety symptoms ("emotional distress") despite emotional distress predicting poorer... Read More
Gender:
All
Ages:
40 years and above
Trial Updated:
08/02/2023
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: COPD, Depression, Anxiety
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Identifying Right Ventricular Dysfunction in COPD Through Right Heart Catheterization, Imaging and Exercise
NCT05896579
Recruiting
This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response to pulmonary hypertension (high pressure in the lungs) during rest and exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
07/24/2023
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: COPD, Pulmonary Hypertension, Right Ventricular Dysfunction
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Breathe Easier II: A Dyad-based Multiple Behavior Intervention
NCT05956782
Recruiting
This pilot randomized control trial (RCT) will test a 12-week, multiple behavior intervention physical activity and stress management for survivors with early stage lung cancer (stages I-III) and their family members (1 survivor + 1 family member or friend = 1 dyad). The long-term goal of this research is to improve health outcomes for survivors of lung cancer and their family members. The goals of the intervention, Breathe Easier, are symptom reduction (less breathlessness, less fatigue, less... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
07/11/2023
Locations: University of South Carolina, Columbia, South Carolina
Conditions: Lung Cancer, Nonsmall Cell, COPD, Self-Management, Physical Inactivity, Stress, Quality of Life
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Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer
NCT05181826
Recruiting
To acquire blood samples from subjects for various purposes, including: i) determining the sensitivity and specificity of select DNA methylation markers for the detection of various types of cancer, ii) identifying benign conditions that may induce false positive or false negative results, and iii) defining the effects of potential interfering substances, such as chemotherapy drugs.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/10/2023
Locations: Torrance Memorial Physician Network - Cancer Care, Redondo Beach, California +6 locations
Conditions: Cancer, Liver Cirrhosis, Chronic Hepatitis, Hepatitis B, Hepatitis C, Diabetes, COPD
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