There are currently 29 active clinical trials seeking participants for COPD research studies. The states with the highest number of trials for COPD participants are Florida, California, Texas and South Carolina.
MyAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
NCT05204888
Recruiting
Parallel-group, prospective, randomized, controlled phase III trial of home High flow Nasal Therapy (HFNT) via myAirvo 3 plus usual COPD medical care vs. usual COPD medical care, for at least 1 year and up to two years in 642 GOLD Grade D, Stages II-IV patients with moderate to very severe COPD at risk for moderate and severe exacerbations with a prior history of severe exacerbation requiring hospitalization within the past 6 weeks.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
02/05/2025
Locations: UAB School of Medicine/Lung Health Center, Birmingham, Alabama +26 locations
Conditions: COPD
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Pulmonary Hypertension SOLAR
NCT04778046
Recruiting
The main goal of this study is to develop a noninvasive signature for pulmonary vascular remodeling in Group 3 PH patients, using hyperpolarized 129Xe magnetic resonance imaging (129Xe MRI). Such a signature may identify Group 3 PH responders to PAH-specific therapies. PAH's unique 129Xe MRI signature has been shown in previous studies. Past studies have lacked a pathologic "ground truth" correlate of these signatures, which could be provided by comparing them with the pathology of lung explant... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Interstitial Lung Disease, COPD, Pulmonary Arterial Hypertension
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Functional and Structural Assessment of Endobronchial Valve Recipients Using Dynamic Hyperpolarized Xenon-129 MRI
NCT05433961
Recruiting
This study proposes to use hyperpolarized xenon-129 Magnetic Resonance Imaging (MRI) to study lung function of COPD patients who will receive endobronchial valve (EBV) therapy as part of their clinical standard-of-care. Once inhaled, HP xenon can provide information to imagers regarding functionality across specific regions of the lungs through the assessment of the replacement of air during the normal breathing cycle, how much oxygen is in the airspaces, and if the normal spongy tissue structur... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/16/2025
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: COPD
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Physiologic Effects of Nasal High Flow on Exercise Tolerance in COPD
NCT06578156
Recruiting
This study aims to assess whether to describe the effects of the administration of nasal high flow (NHF) at 70 liters per minute (L/min) in a 6-Minute Walk Test (6-MWT) among Chronic Obstructive Pulmonary Disease (COPD) patients and to characterize the association between self-reported dyspnea with and without NHF at 70 L/min following a 6-MWT.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
12/12/2024
Locations: University of Miami, Miami, Florida
Conditions: COPD
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Revefenacin in Acute Respiratory Insufficiency in COPD
NCT04315558
Recruiting
RARICO is a pragmatic, randomized, controlled, double-blinded, multi-center trial evaluating the safety and feasibility of nebulized revefenacin in comparison to nebulized ipratropium in patients with COPD and acute respiratory failure requiring invasive mechanical ventilation.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
12/09/2024
Locations: Ronald Reagan Medical Center at UCLA, Los Angeles, California +1 locations
Conditions: COPD, Acute Respiratory Failure
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Interprofessional Pharmacogenomics (IPGx) Registry and Repository
NCT06726590
Recruiting
This program collects genetic and health information to help doctors choose the right medications for patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Texas A&M Family Care, Bryan, Texas
Conditions: Diabetes, Cholesterol, Cancer, Blood Pressure Disorders, Heart Disease, Respiratory Ilness, COPD, Adverse Drug Reaction (ADR), Poly Pharmacy
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Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
NCT04179981
Recruiting
Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population. OSA co-occurring with COPD, known as Overlap Syndrome (OVS), is a complex chronic medical condition associated with grave consequences. OVS is highly prevalent in Veterans. Veterans with OVS may be at increased risk for cognitive deficits, poor sleep quality as well as a reduced quality of life (QoL). The overall objective is to study the eff... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
10/02/2024
Locations: VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor, Michigan +1 locations
Conditions: Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome, Quality of Life, Neurocognitive Function, Sleepiness, Elderly, Positive Airway Pressure
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Acoustic Waveform Respiratory Evaluation
NCT06512064
Recruiting
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
Gender:
ALL
Ages:
Between 8 years and 65 years
Trial Updated:
09/11/2024
Locations: Indiana University, Indianapolis, Indiana +1 locations
Conditions: Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders, Bronchiectasis, Airway Malacia, Healthy Control
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Relationship of Inflammation and Pulmonary Function to Fungal Translocation in HIV
NCT05502653
Recruiting
The investigator will study the origin of fungal translocation in HIV, its relationship to the mycobiome, and its relationship to lung function and inflammation. Supported by the preliminary data and published studies, this project is based on the premise that circulating BDG derived from microbial translocation stimulates inflammation and worsens lung function in PWH. Chronic obstructive pulmonary disease (COPD) is a significant public health problem with few therapies that modify disease traj... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/05/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: HIV Infections, Inflammation, COPD
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Identifying Right Ventricular Dysfunction in COPD Through Right Heart Catheterization, Imaging and Exercise
NCT05896579
Recruiting
This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response to pulmonary hypertension (high pressure in the lungs) during rest and exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
08/05/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: COPD, Pulmonary Hypertension, Right Ventricular Dysfunction
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Telehealth and Onsite Maintenance Exercise in Chronic Lung Disease
NCT06304207
Recruiting
The goal of this pilot clinical trial is to compare telehealth and onsite supervised maintenance exercise program for adults with Chronic Lung Disease. The specific aims of the study are: * To compare 8-week supervised maintenance program delivered onsite and via tele-rehab with no maintenance for patients with Chronic Lung Disease following discharge from traditional exercise or physical therapy or onsite outpatient rehabilitation programs on clinical outcomes (dyspnea, exercise capacity, phy... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
07/30/2024
Locations: MGH Institute of Health Professions, Charlestown, Massachusetts
Conditions: Copd, COPD Exacerbation, COPD Bronchitis, Emphysema or COPD, Chronic Lung Disease, Pulmonary Fibrosis, Interstitial Lung Disease, Bronchiectasis, Chronic Asthma, Chronic Asthmatic Bronchitis
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A Controlled Breathing Intervention to Reduce Stress and Improve Symptoms in COPD Patients (REST)
NCT06404008
Recruiting
This is a parallel design, randomized, controlled pilot trial comparing a controlled breath intervention (REST) to usual care for reducing stress in individuals with COPD.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
07/19/2024
Locations: Ascension Seton Medical Center, Austin, Texas
Conditions: COPD, Stress, Dyspnea
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